In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidance on child camps ...
May 29, 2021•44 min•Ep. 761
Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Peter Daszak , Thea Kølsen Fischer , and Marion Koopmans Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode...
May 27, 2021•1 hr 28 min•Ep. 760
TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls 15:10 Porcine deltacoronavirus in Haitian children (medRxiv) C...
May 23, 2021•2 hr 8 min•Ep. 759
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this...
May 22, 2021•45 min•Ep. 758
TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls 2% of SARS-CoV-2 positives carry most viral RNA (PNAS) Pan-c...
May 20, 2021•2 hr 2 min•Ep. 757
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine to...
May 16, 2021•2 hr 14 min•Ep. 756
In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Moderna vaccine safe, effective in teens (AAP news) Review of outdoor transmis...
May 15, 2021•41 min•Ep. 755
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Michelson Prizes FDA authorizes Pfizer/BioNTech mRNA vaccine for adolescent...
May 13, 2021•1 hr 36 min•Ep. 754
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Sputnik Light Ferret airborne transm...
May 09, 2021•1 hr 43 min•Ep. 753
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS ,...
May 08, 2021•44 min•Ep. 752
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Brazil rejects Gamaley...
May 06, 2021•1 hr 34 min•Ep. 751
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine education town halls (ASV) RSV cpDVG may influence clinical outcome (Nat ...
May 02, 2021•2 hr 10 min•Ep. 750
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Summer camp guidance (CDC) Protect yourself when fully vaccinated (CDC) Updated recomme...
May 01, 2021•40 min•Ep. 749
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode In-host SARS-CoV-2 evolution drive by antibody (PLoS Path) COVID-19 and CVT (OSF) CoronaVac underperfor...
Apr 25, 2021•1 hr 46 min•Ep. 748
Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19. Hosts: Daniel...
Apr 24, 2021•43 min•Ep. 747
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Viral brain entry by transcytosis across endothelial cells (mBio) Scientists attitud...
Apr 22, 2021•1 hr 52 min•Ep. 746
Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Guest: Nadine Lamberski Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Gorillas receive COVID-19 vaccine (Nat Geo) COVID-19 vaccine for great apes and mink (Zoetis) Letters read on TWiV 745 Timest...
Apr 18, 2021•1 hr 48 min•Ep. 745
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Healthcare worker deaths (Guardian) Children and adolescen...
Apr 17, 2021•45 min•Ep. 744
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pleomorphic virus particles and cell entry (Nat Micro) Letters read on TWiV 743 T...
Apr 15, 2021•1 hr 55 min•Ep. 743
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (N...
Apr 11, 2021•1 hr 48 min•Ep. 742
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children with MIS-C (JAMA) Transmission with masks (Op For Inf Dis) Accuracy of diagnostic tests (J C...
Apr 10, 2021•43 min•Ep. 741
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hos...
Apr 08, 2021•1 hr 37 min•Ep. 740
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Guest: Arturo Casadevall Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Victory for Scienti...
Apr 04, 2021•1 hr 55 min•Ep. 739
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pfizer mRNA vaccine is 100% effecti...
Apr 03, 2021•35 min•Ep. 738
John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Kathy Spindler Guest: John Dennehy , Davida Smyth , and Monica Trujillo Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron...
Apr 01, 2021•1 hr 55 min•Ep. 737
Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Kathy Spindler Guest: Alessandro Sette Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for...
Mar 28, 2021•2 hr 2 min•Ep. 736
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 in primary and secondar...
Mar 26, 2021•40 min•Ep. 735
Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection. Hosts: Vincent Racaniello, Rich Condit , Alan Dove , Brianne Barker , and Amy Rosenfeld Guest: Susan Weiss Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CoV pathogenesis in CNS (J Neuro Pharm) SARS-CoV-2 ...
Mar 21, 2021•2 hr 11 min•Ep. 734
In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effectiveness of 3 ft vs 6 ft (CID) ...
Mar 20, 2021•34 min•Ep. 733
Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Forest on TWiV 391 Swabbing surfaces in San Diego (10News) Nido21 meeting Molnupira...
Mar 18, 2021•1 hr 52 min•Ep. 732
