TWiV 734: Weiss hath no furin like a virus scorned

Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld

Guest: Susan Weiss

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• CoV pathogenesis in CNS (J Neuro Pharm)
• SARS-CoV-2 induces dsRNA-mediated innate responses (bioRxiv)
• Screen of FDA-approved drugs (J Viral)
• Letters read on TWiV 735
• Timestamps by Jolene. Thanks!

Brianne – Tiktok of How mRNA Vaccines Work Alan – Dark Rich – Unmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217 Amy – MOMA Calder exhibit, reviewed in NYTimes Vincent – Ripple Training (free YouTube channel)

Ruth – 100 million year old seafloor bacteria resuscitated Iradis – Linda Zall, CIA spy for science

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv