This Week in Virology - podcast cover

This Week in Virology

Vincent Racaniellowww.microbe.tv
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
Download Metacast podcast app
Podcasts are better in Metacast mobile app
Don't just listen to podcasts. Learn from them with transcripts, summaries, and chapters for every episode. Skim, search, and bookmark insights. Learn more

Episodes

TWiV 731: The kids aren't alright

On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK. Hosts: Vincent Racaniello, Rich Condit , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ebolavirus disease outbreak continues in Africa (ProMedMail) List of Ebolavirus outbreaks...

Mar 14, 20211 hr 55 minEp. 731

TWiV 730: COVID-19 clinical update #53 with Dr. Daniel Griffin

In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 seroprevalence in <...

Mar 13, 202145 minEp. 730

TWiV 729: A floret of spikes with Matt Frieman

Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Matt Frieman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Phase 1-2 trial of Novavax protein vaccine (NEJM) MERS-CoV spike nanoparticle vaccine in mice (Vacc...

Mar 11, 20211 hr 57 minEp. 729

TWiV 728: Cover your nose and mouse

TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mavis Agbandje-McKenna dies...

Mar 07, 20212 hr 12 minEp. 728

TWiV 727: COVID-19 clinical update #52 with Dr. Daniel Griffin

In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 attack rates in children and adults (C...

Mar 06, 202135 minEp. 727

TWiV 726: Molecular animator Janet Iwasa

Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells. Hosts: Vincent Racaniello, Rich Condit , Brianne Barker and Kathy Spindler Guest: Janet Iwasa Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The Animation Lab SARS-CoV-2 animation Documents for J&J COVID-19 vaccine revie...

Mar 04, 20211 hr 53 minEp. 726

TWiV 725: Eva Harris and Janet Smith clip flavivirus wings

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-media...

Feb 28, 20211 hr 59 minEp. 725

TWiV 724: COVID-19 clinical update #51 with Dr. Daniel Griffin

In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Updated NYC mask guidance (NYC Health) Two masks recommen...

Feb 27, 202137 minEp. 724

TWiV 723: COVID-19 palliative care with Ginger Campbell, MD

Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guest: Ginger Campbell, MD Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Brain Science Podcast Dr. Campbell’s video on palliative care (YouTube) Resources on palliative care (WHO) Interviews with Paul Offit ( one , tw...

Feb 25, 20211 hr 48 minEp. 723

TWiV 722: More coronaviruses in the pipeline

The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 in Manaus (Lancet) SARS-CoV-2 related viruses in ...

Feb 21, 20212 hr 2 minEp. 722

TWiV 721: COVID-19 clinical update #50 with Dr. Daniel Griffin

In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidance on school openings (CDC) Calcifedio...

Feb 20, 202130 minEp. 721

TWiV 720: With vaccines, Offit is on it

Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine education ...

Feb 14, 20212 hr 1 minEp. 720

TWiV 719: COVID-19 clinical update #49 with Dr. Daniel Griffin

In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 ...

Feb 13, 202128 minEp. 719

TWiV 718: Recombining vaccine schedules

TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode AZD1222 single dose efficacy and booster timing (Lancet preprint) Safety and efficacy of Sputnik V vaccine (La...

Feb 11, 20211 hr 52 minEp. 718

TWiV 717: Paul and Theodora, pandemic explorers

Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guests: Paul Bieniasz and Theodora Hatziioannou Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Evolutio...

Feb 07, 20211 hr 57 minEp. 717

TWiV 716: COVID-19 clinical update #48 with Dr. Daniel Griffin

In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a pat...

Feb 06, 202152 minEp. 716

TWiV 715: Fauci ouchy

TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TMPRSS2 is why hydroxychloroquine failed (PLoS Path) Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) Letters read on TWiV 715 Timestamps by Jolene ....

Feb 04, 20211 hr 50 minEp. 715

TWiV 714: The shape of spike with Jason McLellan

Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Guest: Jason McLellan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Prefusion spike structure (Scienc...

Jan 31, 20212 hr 7 minEp. 714

TWiV 713: COVID-19 clinical update #47 with Dr. Daniel Griffin

In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Novavax vaccine phase 3 results (Novavax) J&J vaccine phase 3 results (J&J) COVID-1...

Jan 30, 202135 minEp. 713

TWiV 712: Deutscher Virus Wahnsinn

Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guests: Gisa Gerold , Stefanie Becker , and César Muñoz-Fontela Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode German Society for Virology Ticks in Germany and TBEV (Sci Rep) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions ...

Jan 28, 20211 hr 38 minEp. 712

TWiV 711: The New Heal

The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Biden’s COVID-19 strategy ( pdf ) CDC evaluation of BinaxNOW antigen test (MMWR) FDA instructions for BinaxNOW test ( pdf ) ...

Jan 24, 20212 hrEp. 711

TWiV 710: COVID-19 clinical update #46 with Dr. Daniel Griffin

In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron...

Jan 23, 202135 minEp. 710

TWiV 709: COVID cherry picking

In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode President’s science advisor to Cabinet (NY Times) Letter from Biden to Lander ( pdf ) Weekly flu (CDC)...

Jan 21, 20211 hr 30 minEp. 709

TWiV 708: Alpaca llama full of nanobodies

The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times)...

Jan 17, 20212 hr 1 minEp. 708

TWiV 707: COVID-19 clinical update #45 with Dr. Daniel Griffin

In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode J&J Ad26 vaccine phase 1/2 results (NEJM) SARS-CoV-2 encephalitis is a cytok...

Jan 16, 202140 minEp. 707

TWiV 706: Do as Dr. Fauci says

TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse 2020 US traffic deaths (Car & Driver) National Vaccine Injury Compensation Program (HRSA) Jet injector (Wikipedia) Letters read on TWiV 706 Timestamps by Jolene . Than...

Jan 14, 20211 hr 36 minEp. 706

TWiV 705: Rocky Mountain COVID with Emily Travanty

Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Emily Travanty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode VOC detected in Colorado (WaPo) US has sequenced only 50,000 SARS-CoV-2 genomes (CDC) Huma...

Jan 10, 20211 hr 51 minEp. 705

TWiV 704: COVID-19 clinical update #44 with Dr. Daniel Griffin

In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Argentine study on plasma therapy (NEJM) Ct values and clini...

Jan 09, 202132 minEp. 704

TWiV 703: Does dose matter?

On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position Follow authorize...

Jan 07, 20212 hr 5 minEp. 703

TWiV 702: Year of the Pandemic

For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse This little virus went ...

Jan 03, 20211 hr 37 minEp. 702
Hosted on Libsyn
For the best experience, listen in Metacast app for iOS or Android
Open in Metacast