TWiV 740: Complementation will get you everywhere
Episode description
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode- NIDO 2021 Symposium
- ASV hosts free COVID-19 Vaccine Education Town Halls (register here)
- Research position in Spindler laboratory
- Attenuation of poliovirus by codon deoptimization (Science)
- Rescue of codon-deoptimized RSV by large deletions (PNAS)
- Letters read on TWiV 740
- Timestamps by Jolene. Thanks!
Dickson – Let us now praise tiny ants Brianne – Small-school science Rich – Smallpox 'virus squads' and the mandatory vaccinations upheld by the Supreme Court Kathy – The Transcontinental Burrito Tunnel Vincent – Glass music by Robert Tiso
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv