TWiV 742: De-fusing COVID-19

This Week in Virology

Apr 11, 2021•1 hr 48 min•Ep. 742

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Episode description

TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Links for this episode

TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Nature)
Letters read on TWiV 742
Timestamps by Jolene. Thanks!

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