TWiV 742: De-fusing COVID-19

This Week in Virology

Apr 11, 2021•1 hr 48 min•Ep. 742

--:--

Listen in podcast apps:

Listen to this episode in Metacast mobile app

Don't just listen to podcasts. Learn from them with transcripts, summaries, and chapters for every episode. Skim, search, and bookmark insights. Learn more

Episode description

TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Nature)
Letters read on TWiV 742
Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – COVID-19: a disaster five years in the making
Alan – The Tyranny of Merit
Rich – Racism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
Vincent – Trudy Rey’s YouTube Channel

Listener Picks

Jeff – Rebecca Lee Smith on Left Right and Center
Ryan – Perfect Strangers (clip)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

For the best experience, listen in Metacast app for iOS or Android

Open in Metacast