In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. This is Part 2. Listen to episode 24 to hear part 1. 00:01:31 - Question about taking naps to make up for not enough sleep 00:03:06 - REM Sleep and Deep Non-REM Sleep 00:11:54 - Shift work is very detrimental to to health ...
Aug 21, 2023•27 min
Buck discusses Heart Rate Variability (HRV). What is it? Why does it matter and how can it effect your overall health in this mini Sapio with Buck Joffrey episode. 00:00:31 - Medicine 3.0: Taking medicine into your own hands 00:01:15 - What is Heart Rate Variability (HRV) anyway? 00:02:16 - The Autonomic Nervous System 00:02:37 - The Parasympathetic Nervous System 00:03:32 - Lower Hrv Has Been Linked To An Increased Risk Of Cardiovascular Diseases 00:04:18 - Ways To Increase Your HRV...
Aug 16, 2023•6 min
In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. Part 2 will drop next week as episode 26. 0:01:11 - Question about Continuous Glucose Monitoring and Repatha® 0:04:34 - Where is the glucose coming from in the morning? 0:07:07 - Blood Glucose Spike in the sauna 0:09:43 - ...
Aug 14, 2023•44 min
Planning a trip? Jet lag can be a serious impediment to making the most of it. Buck discusses jet lag; what it is and strategies to beat it including the use of Melatonin. 00:00:25 - Desynchronosis - Disruption To Your Circadian Rhythm 00:01:05 - Melatonin 00:02:39 - Bright Light Exposure Is Really Important To Resetting Your Circadian Clock 00:04:48 - Some Negative Effects Of Chronic Melatonin Use
Aug 09, 2023•6 min
Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. This is Part 2. If you missed Part 1, check out episode 20. 0:01:16 - Metabolic Markers and Cardiovascular Risk 0:01:55 - Framingham Risk 0:06:08 - Hemoglobin A1C 0:08:00 - C-peptide 0:09:07 - Homocysteine and the methylation cycle 0:11:50 - Methyl Protect® 0:13:46 - Why is Vitamin D important? 0:21:34 - APOE Genotype 0:24:35 - Alzheimer's Disease Risk 0:28:57 ...
Aug 07, 2023•34 min
Scary news last week when Bronny James, the 18 year old son of Lebron and Savannah James collapsed during a workout at USC. It has been reported that James suffered a cardiac arrest. In September 2022 another seemingly healthy and fit USC basketball player, Vince Iwuchukwu also suffered cardiac arrest. Thankfully USC was prepared and in both cases they were able to get these young athlete's hearts beating again. Buck discusses why and how it happens. 0:00:11 - Bronny James’ cardiac arrest 0:00:5...
Aug 02, 2023•6 min
Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. Part 2 will drop as Episode 22. 0:01:31 - What exactly is a Cardio IQ? 0:03:15 - the cost of Cardio IQ 0:05:18 -Lipid panel, Total Cholesterol, HDL, Triglycerides, LDL Cholesterol 0:08:29 - HDL the so-called good cholesterol 0:13:55 - Lipoproteins 0:15:42 - LDL Particle Number 0:22:46 - Apolipoproteins 0:25:40 - Apolyte protein tag 0:27:48 - Apolipoprotein B or...
Jul 31, 2023•48 min
In this episode Buck discusses snoring and sleep apnea and why they should be taken seriously. 0:01:17 - Snoring And Sleep Apnea 0:01:45 - Up To 20% Of The Population Has Clinically Relevant Sleep Apnea 0:02:52 - Central Sleep Apnea 0:03:12 - Obstructive Sleep Apnea 0:03:34 - Sleep Apnea Is The Enemy Deep Sleep 0:03:59 - Increased Risk Of Diseases Associated With Sleep Apnea 0:05:32 - Sleep Apnea Screening 0:05:56 - Epworth Sleepiness Scale https://epworthsleepinessscale.com/about-the-ess/ 0:06:...
Jul 26, 2023•10 min
Buck talks with GRAIL President Josh Ofman, MD, MSHS, about their groundbreaking Multi-cancer early detection (MCED) technology and it's promise as a significant new tool in the war on cancer. 0:00:00 - Advancements in Cancer Detection Technology 0:00:35 - GRAIL Galleri test 0:02:11 - About Dr. Josh Ofman 0:05:14 - Cancer really is a disease of the genome 0:12:35 - Various guidelines for early detection of certain cancers 0:16:45 - Cancer Detection in Blood Biology 0:19:03 - Cell-Free DNA 0:23:3...
Jul 24, 2023•52 min
In this Sapio Short Buck discusses the news last week that the World Health Organization (WHO) has declared the artificial sweetener Aspartame a "a possible carcinogen". So what does this classification mean for you and how worried should you be? 0:00:13 - World Health Organization classified aspartame as a possible carcinogenic substance 0:02:03 - Group 2B - the possibly carcinogenic to humans category 0:03:18 - WHO concedes that the upper limit for safe daily consumption of aspartame is equiva...
Jul 19, 2023•5 min
In this episode, Alan Viglione, MD joins Buck to answer some of our audience questions. 0:01:08 - How To Prevent The Dawn Phenomenon Or Rise Of Sugar Levels During Sleep Or Early Morning 0:04:44 - Hemoglobin A1C 0:08:00 - What Is Gluconeogenesis? 0:14:24 - Managing Dawn Phenomenon 0:18:04 - A Question About Geroprotectant Supplements 0:19:37 - Nicotinamide Riboside As A Precursor to NAD+ 0:26:02 - What Is A Senolytic? 0:29:29 - Benefits Of Senolytics 0:30:27 - Promising Potential Of Quercetin 0:...
Jul 17, 2023•1 hr 10 min
In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. 0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life 0:03:33 - Average Age When Women Experience Menopause And Perimenopause 0:06:51 - Pharmaceuticals Developed To Address Menopausal Symptoms In W...
Jul 13, 2023•37 min
Buck discusses Male Hormone Replacement with Rob Hamilton, MD from Prestige Regenerative Medicine. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. Human Growth Hormone is also discussed in this hour-long discussion. 0:00:12 - Rob Hamilton’s Background 0:04:44 - What Happens With These Kinds Of Male Sex Hormones Over Time? 0:05:46 - Declining Testosterone Levels In Men Aged 35 To 40 0:09:23 - Testosterone Is An Anabolic Hormone 0:11:17 - ...
Jul 12, 2023•57 min
In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. 0:00:29 - What Is Psilocybin? 0:01:42 - The Serotonergic Effects Of Psilocybin 0:04:08 - Exploring The Effects Of Microdosing Psilocybin 0:09:16 - Microdosing And Euphoria 0:12:03 - Exploring Psychedelic Microdosing 0:15:31 - The Fadiman Protocol 0:17:10 - The Stamets Protocol 0:19:59 - Microdosing Ketamine And Serotonergic Function...
Jul 05, 2023•24 min
In this is a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. Part 2 will be online for our regular Wednesday episode drop. 0:00:39 - About Dr. Michael Mantz 0:02:47 - Studying With Famous Herbalists In Utah 0:06:46 - Dr. Mantz's Integrative Approach Combining Nutrition, Exercise And Supplements 0:08:21 - Dr. Mantz's Current Practice: The Santa Barbara Integrative Medicine 0:08:43 - Ketamine Assisted Psychotherapy 0:11:06 - What Are Psychedelics? 0:12:49 - U...
Jul 04, 2023•1 hr 7 min
Buck discusses studies on the effect of saunas for overall health and longevity. 0:01:35 - What's The Big Deal With Saunas? 0:02:03 - Kuopio Ischemic Heart Disease Study 0:04:44 - Sauna Benefits For The Body 0:04:53 - Heat Shock Proteins 0:07:30 - Increased Expression Of Brain Derived Neurotrophic Factor 0:09:05 - Saunas And Longevity 0:11:08 - Blood Glucose Spikes While In The Sauna 0:12:19 - Optimal Timing For Sauna Usage...
Jun 28, 2023•16 min
Buck and Montecito Concierge Medicine’s Alan Viglione explore compelling studies revealing the profound impact of social connections on our longevity. Join us as we uncover the fascinating evidence that demonstrates how fostering relationships can unlock the secret to a longer, more fulfilling life. 0:00:09 - Last Pillar Of Longevity: Social Relationships 0:01:11 - Tribal Societies And The Common Goal Of Survival 0:01:29 - Human Beings Are Fundamentally Social Creatures 0:03:41 - Social Relation...
Jun 26, 2023•23 min
Buck discusses with Executive Producer Ben Hyatt a study that appeared June 9th, 2023 in Science magazine that linked Taurine with healthy aging and increased lifespan in animal studies. 0:01:30 What we knew about Taurine before the study. 0:03:22 What is Taurine? 0:03:39 What new information did we learn from the study? 0:06:30 Why do multiple models matter when it comes to studies? 0:07:04 What is the mechanism between improvements in health span and longevity? 0:07:30 Cellular Senescence - wh...
Jun 21, 2023•14 min
Shownotes: 1:02 What is Diagnostics when it comes to medicine? 2:35 What are some of the traditional Diagnostics used in Medicine 2.0? 4:11 - Summarize the basic screenings you should be getting starting at based on Medicine 2.0 guidelines 6:09 Why are PSA screenings controversial? 8:19 - Cardiovascular testing - medicine 2.0 8:53 - Medicine 3.0 9:26 What’s a Cardio IQ? 18:10 Genetic Screening 19:40 MTHFR Gene Mutation 21:58 APOE e3 and e4 23:00 ACTN Gene 24:06 Galleri® Test 27:27 Whole Body MRI...
Jun 19, 2023•48 min
Shownotes: 0:01:04 Metformin and Diabetes 0:02:48 Metformin Monotherapy 0:06:46 Are There Any Geroprotective Benefits From Taking Metformin? 0:10:50 Benefits of Rapamycin and 0:12:14 Acarbose and Sugar Metabolism 0:16:28 SGL2 inhibitor Jardiance 0:20:37 Glucose Monitoring and Metformin
Jun 15, 2023•23 min
Shownotes: 0:01:54 Geroprotective Medication 0:09:51 Addressing Fear Of Medication 0:12:22 Preventing Cardiovascular Disease 0:15:27 PCSK9 Inhibitors 0:16:48 Cardio IQ Test 0:17:02 Cardiac Risk Algorithm 0:21:10 Metformin 0:26:09 Interventions Testing Program (ITP) 0:27:32 Rapamycin 0:29:52 Acarbose 0:31:46 Invokana 0:39:29 NMN Supplementation
Jun 12, 2023•49 min
Shownotes: 0:01:31 The Importance Of Sleep For Health 0:03:41 Rapid Eye Movement (REM) Sleep 0:03:57 Non-REM Sleep 0:06:22 Sleep Problems and Links to Alzheimer's and Dementia 0:08:14 Glial–Lymph and Deep Sleep 0:10:14 REM Sleep And Brain Health 0:14:28 Sleep Apnea: Berlin questionnaire and STOP-Bang assessment 0:17:04 Oura Ring 0:17:57 Sleep Disruption and Cancer 0:23:26 Night Shift Work And Health Risks 0:24:28 Suprachiasmatic Nucleus (SCN) and the Sleepway Cycle 0:26:35 Sleep And Longevity 0:...
Jun 05, 2023•43 min
Our understanding of how to get the most out of exercise has evolved. A combination of cardio training with weight training can have a profound effect on longevity and quality of life. Learn how to get the most out of your exercise and what metrics you can track to measure your fitness! Shownotes: 0:00:33 Hormesis and Challenging the Body 0:02:48 The Benefits Of Exercise 0:04:07 The Cardiovascular System 0:06:25 Levels Of Cardiovascular Exercise Intensity 0:06:35 Level One: Walking Down The Stre...
May 29, 2023•47 min
In this bonus Q&A episode Buck Joffrey dives a little deaper into one of the key Episode 2 topics - blood glucose and how it affects your body with Sapio Executive Producer Ben Hyatt. Shownotes: 0:01:36 Understanding Glucose and Insulin Interaction 0:06:19 Food Combinations and Blood Sugar 0:10:56 Understanding Diabetes and Glycation 0:16:13 Diabetes and Testing
May 26, 2023•27 min
There is more to healthy eating than calories in and calories out. Learn the new science around eating to extend life including what to eat and when! Shownotes: 0:00:03 Pillars of Longevity: Diet and Nutrition 0:04:29 Caloric Restriction and Timing of caloric intake 0:09:29 Impact of Carbs on Intermittent Fasting 0:18:46 Managing Blood Sugar and Identifying Pre-Diabetes 0:19:49 The Importance of Hemoglobin A1c 0:23:49 Personalized Response to Glucose Spikes 0:27:55 Eating Fads and Diets...
May 20, 2023•35 min
An Introduction to the pillars on longevity and underlying science. Buck talks with Montecito Concierge Medicine’s Alan Viglione. Shownotes: 0:00:31 Introduction to Sapio 0:03:53 Pillars of Longevity 0:04:17 Food and Nutrition 0:05:10 Exercise 0:06:33 Supplements that can make you live longer 0:08:29 Sleep 0:10:22 Diagnostics 0:10:57 Relationships
May 19, 2023•14 min
