In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae. Ho...
Jun 19, 2021•39 min•Ep. 770
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier. Hosts: Vincent Racaniello , Kathy Spindler, and Brianne Barker Click arrow to play Download TWiV 769 (68 MB .mp3, 114 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 ...
Jun 17, 2021•1 hr 46 min•Ep. 769
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall Spread of SARS-CoV-2 variant in summer 2020 (Nature...
Jun 13, 2021•1 hr 49 min•Ep. 768
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitali...
Jun 12, 2021•40 min•Ep. 767
David joins TWiV to relate how his near-death experience with Castleman's disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: David Fajgenbaum Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CORONA project Center for Cy...
Jun 10, 2021•1 hr 26 min•Ep. 766
TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Updated ...
Jun 06, 2021•1 hr 53 min•Ep. 765
In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for ...
Jun 05, 2021•40 min•Ep. 764
TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cap-snatching makes new ORFs (Cell) Cap-snatching leads to novel proteins (Cell) Letters read on TWiV 763 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Flat pasta that turns into...
Jun 03, 2021•1 hr 49 min•Ep. 763
Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Robert Garry Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The proximal origin of SARS-CoV-2 (N...
May 30, 2021•1 hr 54 min•Ep. 762
In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidance on child camps ...
May 29, 2021•44 min•Ep. 761
Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Peter Daszak , Thea Kølsen Fischer , and Marion Koopmans Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode...
May 27, 2021•1 hr 28 min•Ep. 760
TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls 15:10 Porcine deltacoronavirus in Haitian children (medRxiv) C...
May 23, 2021•2 hr 8 min•Ep. 759
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this...
May 22, 2021•45 min•Ep. 758
TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls 2% of SARS-CoV-2 positives carry most viral RNA (PNAS) Pan-c...
May 20, 2021•2 hr 2 min•Ep. 757
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine to...
May 16, 2021•2 hr 14 min•Ep. 756
In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Moderna vaccine safe, effective in teens (AAP news) Review of outdoor transmis...
May 15, 2021•41 min•Ep. 755
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Michelson Prizes FDA authorizes Pfizer/BioNTech mRNA vaccine for adolescent...
May 13, 2021•1 hr 36 min•Ep. 754
TWiV revisits Brazil's rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Sputnik Light Ferret airborne transm...
May 09, 2021•1 hr 43 min•Ep. 753
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS ,...
May 08, 2021•44 min•Ep. 752
TWiV examines the claim by Brazil's ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Brazil rejects Gamaley...
May 06, 2021•1 hr 34 min•Ep. 751
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine education town halls (ASV) RSV cpDVG may influence clinical outcome (Nat ...
May 02, 2021•2 hr 10 min•Ep. 750
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Summer camp guidance (CDC) Protect yourself when fully vaccinated (CDC) Updated recomme...
May 01, 2021•40 min•Ep. 749
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode In-host SARS-CoV-2 evolution drive by antibody (PLoS Path) COVID-19 and CVT (OSF) CoronaVac underperfor...
Apr 25, 2021•1 hr 46 min•Ep. 748
Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19. Hosts: Daniel...
Apr 24, 2021•43 min•Ep. 747
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists' incentives and attitudes towards public communication. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Viral brain entry by transcytosis across endothelial cells (mBio) Scientists attitud...
Apr 22, 2021•1 hr 52 min•Ep. 746
Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Guest: Nadine Lamberski Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Gorillas receive COVID-19 vaccine (Nat Geo) COVID-19 vaccine for great apes and mink (Zoetis) Letters read on TWiV 745 Timest...
Apr 18, 2021•1 hr 48 min•Ep. 745
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Healthcare worker deaths (Guardian) Children and adolescen...
Apr 17, 2021•45 min•Ep. 744
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pleomorphic virus particles and cell entry (Nat Micro) Letters read on TWiV 743 T...
Apr 15, 2021•1 hr 55 min•Ep. 743
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (N...
Apr 11, 2021•1 hr 48 min•Ep. 742
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children with MIS-C (JAMA) Transmission with masks (Op For Inf Dis) Accuracy of diagnostic tests (J C...
Apr 10, 2021•43 min•Ep. 741
