87: The Longevity Clinic Paradigm
Buck discusses the concept of longevity clinics with the CEO of Humanaut. Show Notes: 03:53 What Does Humanaut Do? 06:07 The Team Behind Humanaut 14:49 How Does the Program Work?
Jun 10, 2024•23 min
Longevity Roadmap
Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.
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Episodes
86: The Science of Human Attraction
Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism. Also included is a discussion on the role of human pheromones and attraction. Show Notes: 01:20 Facial Attraction & Cues 08:30 Facial Symmetry 11:12 The Averageness of Facial Features 13:59 Clear and Unblemished Skin 15:44 Sexual Dimorphic Traits 22:23 Smell and Pheromone...
Jun 03, 2024•29 min
85: Fasting, Protein, and Full Body MRI with Dr. Matt Brill
Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI. Show Notes: 01:33 8 Hours Or Less Fasting Window = Higher Chance of Cardiovascular Disease? 04:58 Why the Study that Claimed the Correlation Was Wonky 08:02 ...
May 27, 2024•30 min
84: Keto Diet 101
Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer’s Disease. Show Notes: 03:08 Why the Keto Diet? 04:15 How Does the Keto Diet Help You Lose Weight? 05:51 Other Benefits of the Keto Diet 09:14 How Does High Blood Sugar Result in Insulin Resistance? 11:44 What Defines a Keto Diet 16...
May 20, 2024•35 min
83: Sexually Transmitted Cancer
Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians. 01:18 HIV 05:26 Hepatitis 09:20 HPV
May 13, 2024•23 min
82: Intro to the Microbiome
Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.
May 06, 2024•25 min
81: Ask the Doctor 04/29/24
Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat. Show Notes: 00:47 Is It Fine That I Sleep Too Much? 08:08 The 40hz Gamma Frequency and How It Relates to Brain Health 13:28 The Anti-Aging Effects of Human Growth Hormone 20:31 Reconsideration of How to Fast 29:22 Potentially Harmful Effect of NMN 33:08 Visceral vs Subcutaneous Fat...
Apr 29, 2024•37 min
80: The Longevity Diet with Valter Longo, PhD
Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet. Show Notes: 01:10 Types of Fasting 03:31 Why Fasting is Beneficial From a Cellular Level 07:00 Intermittent Fasting VS Fast Mimicking Diet 14:05 How Does Fasting Help Cancer Patients 20:37 What Is in the Fast Mimicking Diet 33:38 Pills and Supplements for Fasting Mimicking Diet 41:23 Time-Restricted Feeding Based on Circadian Rh...
Apr 22, 2024•54 min
79: Lies Taught in Medical School: Robert Lufkin, M.D.
Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people’s health. Show Notes: 01:35 Dr. Lufkin’s Personal Journey to Question the Medicine Establishment 04:14 When Did People Start to Take Metabolic Syndrome Seriously? 08:33 What Exactly is Metabolic Synd...
Apr 15, 2024•39 min
78: The Age of Data-Driven Wellness is Here
Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment. Show Notes: 00:58 What Really is Healthspan? 05:06 Biological Age VS Chronological Age 07:41 The Factors that Determine Biological Aging 12:08 What Happens When You Artificially Suppress These Factors 16:58 What is Phenomics and how can it predict diseases? 24:21 How Can You Do Self Tests?
Apr 08, 2024•32 min
77: Ask the Doctor (April Fools Edition)
In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.
Apr 01, 2024•30 min
76: Intermittent Fasting Correlated to Higher Risk of Cardiovascular Death
In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study itself, including some suggestions on how to use this new information. Show Notes: 02:01 Intermittent ...
Mar 25, 2024•28 min
75: Stress, Cortisol and Prevention Strategies
Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets. Show Notes: 02:14 The definition of stress 13:16 Why does stress disrupt circadian rhythms and sleep 16:08 How do we treat stress? 21:23 Nootropics 24:39 Vagal nerve stimulator 28:34 Digital detox and meditation 33:02 Diet for stress
Mar 18, 2024•47 min
74: Aggressive Male TRT Approach, Erectile Dysfunction Drugs, and Alzheimer’s Disease
Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer’s disease. Show Notes: 1:27 Is it true that the testosterone in men in general has gone down? 02:43 Common symptoms of low testosterone 05:15 Normal level o...
Mar 11, 2024•46 min
73: Is a Vegan Diet Healthy?
Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns. Show Notes: 2:55 A plant-based diet for better health? 11:53 Balancing nutritions for the plant-based diet 20:39 Accessibility of the plant-based diet 22:30 Processed plant-based food
Mar 04, 2024•35 min
72: A Different Framework for Health?
Buck Joffrey, MD interviews Anoop Kumar, MD on his perspective on health and wellness. Dr. Kumar is an emergency medicine doctor who is also knowledgeable about traditional Indian Philosophy and medicine. Show Notes: 00:43 Near-Death Experience and Shift in Perspective 07:04 The Three Minds Framework 23:03 Reevaluating the Model of Human Anatomy 27:20 The Four Engines: Nutrition, Movement, Connection, and Rest 39:24 The Four Engines of Health and Healing 41:01 Harnessing the Placebo Effect and S...
Feb 26, 2024•49 min
71: Ask the Doctor 02/19
In this episode, Buck addresses questions from listeners. Topics include: 00:34 What is a healthy range in your weight? 04:28 The dangerous kind of fat 07:53 Male hormone replacement and cancer 13:12 How long does it take for the circadian rhythm to adjust to a new time zone? 18:35 The risk of cell phones?
Feb 19, 2024•26 min
70: The Science Behind Music and Mental Health
Buck Joffrey, MD interviews Dr. Daniel Bowling from Stanford University on the science behind music and mental health. Bowling discusses the fundamentals of musicality and the research that has been done in this relatively new field of music as treatment for health-related issues. Show Notes: 02:59 What is musicality? 04:47 What is tonality? 07:05 How does music affect the brain? 11:20 Music as treatment for mental health 22:22 Does music sharpen our intellect? 27:05 Musical vs pharmaceutical in...
Feb 12, 2024•37 min
69: Glutathione: The Master Antioxidant
Buck Joffrey, MD welcomes pharmacist and glutathione expert Dr. Nayan Patel. This podcast discusses the role of glutathione as an antioxidant including why it is known as the "master" antioxidant. The discussion reviews the physiology of glutathione in the body focussing on disease prevention and also discusses different mechanisms of supplementation. Show Notes: 00:48 What is oxidative stress? 04:12 What is an antioxidant and how does it work? 10:24 Glutathione and its relationship to longevity...
Feb 05, 2024•48 min
68: Food Allergy 101 with Tina Sindher, MD
Buck welcomes Tina Sindher, a specialist in food allergy from Stanford University Medical Center to discuss the basics of food allergy. Topics include root causes of food allergy, prevention, diagnosis, and treatment. Show Notes: 04:33 Does where you live affect your allergies? 06:46 How do you know you have an allergy and not something else? 09:40 Life-threatening allergies explained 13:41 Does allergy develop from childhood? 16:28 What makes some foods trigger allergies? 20:22 Rising gluten se...
Jan 29, 2024•39 min
67: The Silent Global Epidemic Killer
Buck Joffrey, M.D. discusses metabolic syndrome which affects 1/4 of the global adult population and how it underlies the development of virtually every other major cause of death. Show Notes: 00:13 Understanding Metabolic Syndrome 05:29 Criterias of Metabolic Syndrome 23:40: Insulin Resistance and Hyperinsulinemia 24:49: Metabolic Syndrome and Diabetes 37:49: Recommended Lab Tests 42:05: The Health Implications of Liposuction 50:42: The Importance of HSCRP...
Jan 22, 2024•47 min
66: What is the common cold and how do you treat it?
Buck talks about the common cold. He discusses the etiology, the role of cold weather, prevention and treatment of this common and frustrating problem.
Jan 17, 2024•15 min
65: Aging Skin and How to Fight It
Buck interviews Dr. Corey Frucht, MD, PhD, a board-certified dermatologist on the topic of aging skin and skin cancer. This episode explores the causes of aging skin and skin cancer, as well as what we can do to combat the inevitable effects of skin aging. Show Notes: 00:00:50:12 How and why can skin look young or old? 00:03:51:20 Why does the skin of people of color age slower? 00:05:14:09 How exactly does UV light damage your skin? 00:07:05:01 Sunscreen 101 00:11:41:08 Physical blockers vs che...
Jan 15, 2024•41 min
63: A Look Back at 2023
In this special New Year episode, Buck reviews some of the concepts discussed on the show in 2023.
Jan 01, 2024•57 min
62: Ask the Doctor 12/25
In this episode, Buck addresses questions from listeners. Topics include oral hygiene, Alzheimer’s disease, and Matthew Perry’s ketamine-related death.
Dec 25, 2023•23 min
61: Wisdom Wednesday: Surviving vs Winning
Buck talks about mindset and the self-inflicted limits of the “survivor.”
Dec 20, 2023•3 min
60: Inflammaging
Buck Joffrey, MD summarizes his literature search on what the data says in regards to the mechanisms by which the most common diseases of age such as cardiovascular disease and cancer might be correlated with chronic inflammation. There is also a discussion around the role of therapeutics and supplements as it relates to treating chronic inflammation and aging related disease.
Dec 18, 2023•40 min
59: How Much Exercise Is Too Much For Longevity?
In this brief video, Buck Joffrey discusses literature suggesting that there is a "Goldilocks" zone for exercising for longevity. He also talks about the research on ultramarathoners suggesting that the once an upper limit of exercise is exceeded, risks to health potentially outweigh the benefits.
Dec 13, 2023•5 min
58: A Review on the Risks and Benefits of Human Growth Hormone Supplementation
Buck reviews the physiology behind human growth, hormone in humans. He discusses normal growth hormone patterns as people age, pathologies and studies of people with both growth, hormone deficiencies and excess. Buck also discusses the risks and benefits of human growth hormone supplementation in otherwise normal middle-aged adults.
Dec 11, 2023•36 min
57: How Stress Impacts Your Body
Stress is an unavoidable element in modern society. Inherently, We know it’s bad for us. In this episode of Sapio, Buck looks at the scientific and medical literature to drill down on the real health implications of health and offers some proven stress relief strategies. 00:00:27:24 What happens in your body when you get stressed? 00:06:26:03 How to decrease your level of stress?
Dec 06, 2023•12 min
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