In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain’s heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolyti...
Jul 14, 2025•29 min
In this conversation, Professor S. Jay Olshansky discusses the evolution of aging science, the realistic limits of human life expectancy, and the concept of the Longevity Dividend, which emphasizes the health and economic benefits of modulating the aging process. He also explores the potential of biomarkers in predicting longevity, the societal implications of an aging population, and the ethical considerations surrounding advancements in longevity science. Learn more about Professor S. Jay Olsh...
Jul 07, 2025•30 min
In this episode, Dr. Michael Lustgarten discusses his research on the gut microbiome, serum metabolome, and muscle health in older adults. He shares insights from his journey into the world of aging, the importance of data in health optimization, and the emerging concept of the gut-muscle axis. Dr. Lustgarten emphasizes the significance of metabolites in predicting longevity and the need for personalized health tracking. He also addresses the balance of exercise and the role of fecal microbiota ...
Jun 30, 2025•30 min
In this conversation, Dr. Stephan J. Guyenet joins Dr. Buck Joffrey to discuss the complex mechanisms of body fat regulation, focusing on the role of the lipostat and leptin. He explains how the body regulates fatness through hormonal signals and the implications of leptin resistance in obesity. The discussion also covers practical strategies for weight management, the impact of stress and sleep on leptin levels, and critiques of the carbohydrate insulin model of obesity. Learn more about Dr. St...
Jun 23, 2025•29 min
Dr. David Furman and Dr. Buck Joffrey discuss the complexities of immune aging, the role of inflammation in age-related diseases, and how artificial intelligence is being utilized to enhance research in this field. He introduces the concept of the inflammatory age clock, which measures biological aging through immune system signals, and explores potential therapeutic interventions, including nutraceuticals and therapeutic plasma exchange. The discussion also touches on the future of aging resear...
Jun 16, 2025•30 min
In this conversation, Dr. Tara Walker discusses the fascinating topic of adult neurogenesis, the brain's ability to produce new neurons throughout life. She explains how this process is crucial for cognitive function and how it declines with age. The discussion highlights the significant role of exercise in boosting neurogenesis and introduces selenium as a key factor in this process. Dr. Walker also explores the implications of her research for cognitive health, particularly in the context of n...
Jun 09, 2025•22 min
Sleep is the secret weapon for a longer, healthier life—and Dr. Michael Breus is here to show you how to use it. In this episode of Longevity Roadmap , Buck Joffrey dives deep into the science of sleep with the world-renowned sleep doctor himself. Discover why sleep is the third pillar of longevity , how REM sleep and deep sleep fuel physical and emotional restoration, and what your chronotype reveals about your ideal sleep patterns . From the effects of sleep deprivation on metabolism and aging...
Jun 02, 2025•57 min
What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unl...
May 26, 2025•43 min
Vitamin D is more than a vitamin—it's a hormone that influences everything from your immune system to cardiovascular health, cognition, and longevity. In this conversation, Dr. Michael Holick breaks down the science of vitamin D synthesis , the truth about sun exposure vs. supplements , and why vitamin D deficiency is far more common—and more dangerous—than most people realize. You'll learn how skin pigmentation , UVB exposure , and supplementation protocols impact your vitamin D levels, and why...
May 19, 2025•43 min
Is your memory decline normal—or something more? Clinical neuropsychologist Dr. Mitchell Clionsky breaks down what healthy aging looks like from a cognitive perspective and where concern might be warranted. He introduces the Memory Orientation Screening Test (MOST) —a powerful yet quick tool to assess cognitive health—and shares insights from decades of evaluating memory, dementia, brain injuries, and CTE. From preventive strategies that could reduce dementia risk by nearly 50%, to how technolog...
May 12, 2025•32 min
What if your body already had everything it needs to heal itself—naturally? In this episode, neurophysiologist and stem cell researcher Dr. Christian Drapeau breaks down the science of stem cell therapy , explaining how adult stem cells , embryonic stem cells , and exosomes play a central role in regenerative medicine and longevity. Discover how aging affects the body’s ability to mobilize stem cells, how injury signals guide them, and why immune system function is tightly linked to stem cell ac...
May 05, 2025•45 min
Is it possible to rejuvenate the immune system as we age? In this episode, Dr. Alessio Lanna breaks down the science of immune aging, focusing on the critical role of T cells, telomere shortening, and senescence. He explains how T cells lose their effectiveness over time—and shares emerging research on how intercellular telomere transfer and the ESMAC complex may help reverse immune senescence. Learn how pharmacological interventions could unlock new possibilities for health, longevity, and immu...
Apr 28, 2025•33 min
Are your mitochondria aging faster than you are? In this episode, Dr. Mark Tarnopolsky breaks down the central role of mitochondria in aging, longevity, and overall metabolic health. Learn how mitochondrial dysfunction drives age-related decline, including neurodegenerative diseases, and what you can do about it. From the paradox of oxidative stress to the risks of overusing antioxidants, this conversation unpacks what actually supports mitochondrial health—including a clinical “mitochondrial co...
Apr 21, 2025•52 min
What if aging isn’t just inevitable—but modifiable? In this episode of Longevity Roadmap , Dr. Matt Kaeberlein breaks down the science of biological aging , with a focus on mTOR , epigenetics , and the hallmarks of aging like cellular senescence , mitochondrial dysfunction , and epigenetic drift . He explores the role of genetics vs. environment , the promise and pitfalls of metformin , NAD boosters , and senolytics , and why interventions like rapamycin and caloric restriction may extend health...
Apr 14, 2025•1 hr 2 min
Dr. Michael Gershon—legendary Columbia professor and author of The Second Brain —joins us to explain why your intestines might just be running the show. From guinea pig guts that "blew back" to the real reason stress wrecks your digestion, this episode dives deep into the mysterious world of the enteric nervous system. Prepare for gut science, serotonin surprises, and a Woody Allen–esque dose of humor from the father of neurogastroenterology himself. Learn more about Dr. Michael Gershon: https:/...
Apr 07, 2025•35 min
Can muscle growth and longevity coexist? Dr. Keith Baar breaks down the science of exercise, diet, and aging—focusing on the mTOR pathway, muscle hypertrophy, and how resistance vs. endurance training impacts long-term health. Learn how personalized health strategies, isometric exercises, and ketogenic diets influence aging and muscle preservation. This episode is packed with actionable insights for anyone serious about optimizing fitness, metabolism, and longevity. Learn more about Dr. Keith Ba...
Mar 31, 2025•42 min
Could an essential fatty acid discovered in Navy dolphins unlock the secret to healthier aging? In this episode of Longevity Roadmap , Dr. Stephanie Venn-Watson reveals the groundbreaking science behind C15 , an essential fatty acid linked to longevity and reduced disease risk. Learn how metabolomics uncovered the connection between higher C15 levels and healthier dolphins—and why this matters for humans. Dr. Venn-Watson explains how C15 deficiency can accelerate aging, increase the risk of fatt...
Mar 24, 2025•41 min
Suicide rates are rising—and the impact on longevity is profound. In this eye-opening episode of Longevity Roadmap, Dr. Peter Franz dives deep into the intersection of mental health , suicide prevention , and lifespan. He explores why nearly 50% of Americans experience depression , how loneliness accelerates suicide risk, and why digital interventions offer new hope. We also unpack the demographics most at risk, the physiology behind depression and suicidal thoughts, and the critical role of red...
Mar 17, 2025•32 min
Can we reverse aging by regenerating the thymus? In this groundbreaking conversation, Dr. Greg Fahy shares his pioneering research on the thymus gland’s role in immune function, longevity, and epigenetic age reversal. We dive deep into the TRIM study, which demonstrated for the first time that thymus regeneration in humans is possible—and may even turn back the clock on biological aging. Dr. Fahy also explores how growth hormone plays a role in reversing age-related thymic decline, the controver...
Mar 10, 2025•37 min
Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase! Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into the biology of skin aging, the impact of senescent cells, and the cutting-edge strategies OneSkin is using to combat age-related skin conditions. The conversation also explores clinical trials, product ...
Mar 03, 2025•29 min
Buck Joffrey welcomes Dr. Michael Miller and Dr. Jacob Allen for an in-depth discussion on gut health and its vital role in overall well-being. They explore the gut microbiome’s composition, how diet and lifestyle influence its dynamic nature, and the significance of fermented foods and dietary bioactives. The conversation also tackles the controversial topic of leaky gut syndrome, common misconceptions about gut health, and the potential benefits of probiotics. Dr. Allen and Dr. Miller further ...
Feb 24, 2025•1 hr 2 min
Dr. Robert Lustig joins Buck to discuss the alarming state of metabolic health in America, where only 7% of the population is considered metabolically healthy. He breaks down metabolic dysfunction, linking it primarily to mitochondrial inefficiency, and explains how sugar—especially fructose—plays a major role in various health issues. The conversation explores the dangers of ultra-processed foods, identifying key contributors to metabolic dysfunction, including excessive sugar, insufficient fib...
Feb 17, 2025•53 min
In this conversation, Dr. Marta Yanina Pepino discusses her research on taste perception and its implications for metabolic health. She explores how individual differences in taste can influence eating behaviors and obesity risk, the relationship between taste and digestion, and the role of genetics and environment in shaping food preferences. The discussion also covers the potential for dietary interventions to modify taste perception and the impact of GLP-1 medications on appetite and food cho...
Feb 10, 2025•33 min
In this episode, Dr. Vera Gorbunova unpacks the secrets of nature’s longest-lived species—like the naked mole rat and bowhead whale—to uncover the biological mechanisms that keep them healthier for longer. We explore the role of DNA repair, transposable elements, and epigenetics in aging and what these discoveries could mean for human longevity. From mitochondrial function to promising interventions like fucoidan, can we apply nature’s blueprint to extend our own lifespan?
Feb 03, 2025•30 min
Buck Joffrey interviews Professor Andrea B. Maier, a leading expert in geroscience and healthy aging. They discuss the evolution of longevity research, the importance of distinguishing between lifespan and healthspan, and the biological mechanisms of aging. Professor Maier emphasizes the need for precision medicine in interventions and the challenges of supplement quality. They also explore future technologies in longevity research, practical steps for individuals to assess their biological age,...
Jan 27, 2025•43 min
In this conversation, Buck and Dr. Nicola Conlon delve into the significance of NAD (Nicotinamide Adenine Dinucleotide) in aging and longevity. Dr. Conlon explains the role of NAD in cellular energy production, its decline with age, and the consequences of this decline on cellular repair and overall health. They discuss the importance of NAD in activating sirtuins, which are crucial for longevity, and explore the limitations of direct NAD infusions. The conversation concludes with insights into ...
Jan 20, 2025•46 min
Buck and Nikki sit down with Dan Buettner, creator of the Netflix series Live to 100: Secrets of the Blue Zones , to explore the wisdom of the world's longest-lived populations. They dive into the lifestyle, diet, and environmental factors that contribute to longevity, and how you can engineer these principles to extend your healthy lifespan.
Jan 13, 2025•1 hr 11 min
This week on Longevity Roadmap , Buck showcases standout moments from Longevity Junky —another health-focused podcast he co-hosts with actress and model Nikki Leigh. Designed for a broader audience, Longevity Junky makes longevity concepts accessible while delivering valuable insights. Tune in for a curated selection of engaging topics, complete with Buck’s commentary, offering fresh perspectives not covered on Longevity Roadmap .
Jan 06, 2025•1 hr 47 min
Buck Joffrey interviews Martin Gibala, a professor at McMaster University, about High-Intensity Interval Training (HIIT) and its benefits. They discuss the definition of HIIT, its physiological mechanisms, and how it compares to traditional exercise. The conversation also covers the implications of HIIT for different populations, its connection to VO2 max and longevity, practical applications in daily life, safety considerations, and resources for further learning. 00:00 - Introduction to High-I...
Dec 30, 2024•29 min
In this wholesome conversation, Buck and Dr. Ellen Langer discuss the profound connection between the mind and body, emphasizing the importance of mindfulness in health and aging. She shares insights from her groundbreaking studies, including the counterclockwise study, which demonstrated that altering one's mindset can lead to significant health improvements. The discussion also explores how perception influences physical attributes, the detrimental effects of mindlessness, and the potential fo...
Dec 23, 2024•39 min
