In this episode, Buck Joffrey discusses the importance of going beyond the normal scope of testing when it comes to lipid profiles and cardiovascular health management. He emphasizes the significance of understanding cholesterol particles, particularly APO-B, and lipoprotein(a), in assessing heart disease risk. He also highlights preventative strategies to optimize health and mitigate risks associated with cardiovascular disease.
Dec 16, 2024•20 min
In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies. 00:00 - Introduction to Longevity Roadmap 03:08 - Case Study: A 70-Ye...
Dec 09, 2024•19 min
Hey Sapio Fans, I’ve got something really exciting for you today—a chance to win a full-body MRI worth $2,500! This giveaway comes from my new podcast, Longevity Junky (that’s junky with a Y). It’s a fun, insightful show I co-host with actress Nikki Leigh, where we dive into cutting-edge advancements in health and longevity. This week’s episode is all about full-body MRIs from Prenuvo, a groundbreaking technology that can identify over 500 conditions—including deadly cancers and brain aneurysms—...
Dec 02, 2024•3 min
An interview with Aubrey de Grey, a founding father of the longevity movement—the man who coined the phrase 'Longevity Escape Velocity.' Aubrey discusses the transformative potential of damage repair, stem cell therapies, and advancements that are turning science fiction into reality. From reversing cellular damage to extending health spans by decades, this conversation unpacks his cutting-edge research and bold predictions shaping the longevity landscape. Tune in to explore a future where livin...
Dec 02, 2024•1 hr 2 min
This Black Friday and Cyber Monday, I want to share something truly meaningful—the opportunity to invest in your health or the health of someone you love. The Longevity Roadmap Course has already transformed lives, uncovering critical health issues and empowering participants to reverse conditions like borderline diabetes and optimize their health. It’s no exaggeration to say this course has already saved years of good-quality life . This year, why not give the ultimate gift—the gift of health a...
Nov 30, 2024•2 min
Buck interviews Mark Mortenson and Rob Etherington from Clene Nanomedicine, discussing their innovative approach to treating neurodegenerative diseases using clean surface nanocrystals. They delve into the science behind nanoparticles, their role in enhancing mitochondrial function, and the mechanisms of neurorepair. They also cover clinical applications, safety considerations, and the challenges in bringing their nanomedicine to market.
Nov 25, 2024•35 min
In this episode, Buck dives into the groundbreaking work of Dr. David Raubenheimer and Professor Stephen Simpson, renowned nutritional scientists from the University of Sydney. They unpack the "Geometric Framework for Nutrition," a holistic and visual approach that examines how nutrients interact to shape health and aging. From protein leverage to balancing macronutrients for longevity, this conversation challenges conventional calorie counting and offers profound insights into optimizing diet a...
Nov 18, 2024•38 min
Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for in devices.
Nov 11, 2024•38 min
Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apol...
Nov 04, 2024•47 min
Oct 28, 2024•4 min
Dr. Diogo Barardo, Director of Research and Development at Novos, joins Buck to discuss Novos’ innovative approach to longevity supplements, unpacking the differences between biological and epigenetic aging and the impact of the Drug Age database. He details how Novos evaluates compounds for safety and efficacy, the unique ingredients in their flagship NovoScore, and the promising roles of lithium microdoses and NAD precursors. Their conversation also delves into the latest in longevity science,...
Oct 28, 2024•45 min
Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body’s nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there’s a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost ...
Oct 21, 2024•40 min
Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body’s autonomic nervous system balance, showing how lifestyle factors, particularly chronic stress, can undermine well-being. He highlights practical strategies, from breathwork to dietary adjustm...
Oct 14, 2024•38 min
Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID. 02:0...
Oct 07, 2024•19 min
Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, as well as practical steps to minimize exposure to microplastics in daily life.
Sep 30, 2024•21 min
In this episode of Longevity Junky, Buck and Nikki tackle one of the most contentious and polarizing areas of longevity, diet with Bio Layne founder Dr. Layne Norton. Learn more about BioLayne and Dr. Layne Norton: https://biolayne.com/coach/layne-norton/ Full episode in video available on YouTube: https://www.youtube.com/channel/UCh6LlBjtOy7lldU7Ldjw0cw Questions? Send us a message at: www.longevityjunky.com Follow us on social media: Instagram: https://www.instagram.com/longevityjunkypodcast F...
Sep 23, 2024•1 hr 13 min
Buck introduces his brand new podcast, Longevity Junky. In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of brain health in overall longevity.
Sep 16, 2024•1 hr 7 min
Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and everyday activities. Mindfulness meditation can help access flow by improving focus and attention. T...
Sep 09, 2024•25 min
Buck shares his recent experience with a retinal tear and detachment, emphasizing the importance of early diagnosis and treatment to prevent permanent vision loss. He explains the anatomy of the eye, the process of vitreous detachment, and the symptoms of retinal tear and detachment. Buck also discusses the risk factors for these conditions, including high myopia and previous eye surgery. He describes his surgical experience and the use of a gas bubble to reattach the retina.
Sep 02, 2024•17 min
Buck discusses the role of big Tech and the elderly with Keren Etkin, founder of TheGerontechnologist.com. Discussion includes the role of robots, implications for social interaction, as well as the additional opportunities for founders to take advantage of the coming geriatric storm. 01:04 Current Tech for Aging 05:17 Tech for Social-Emotional Support 09:03 The Driving Force Behind the Development 12:00 The Impact of Increasing Longevity 13:54 Affordability of Aging Tech 17:08 Cyborgification...
Aug 26, 2024•23 min
Link to Buck's Results: https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing Section 1: Overview of Cholesterol Metabolism Cholesterol in the Body: Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production. It is produced endogenously in the liver and absorbed exogenously from dietary sources. Endogenous Production: Cholesterol is synthesized in...
Aug 19, 2024•22 min
Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine as an anti-inflammatory treatment for coronary artery disease and atrial fibrillation. 01:23 Unders...
Aug 12, 2024•20 min
This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their association with atherosclerosis. Buck also discusses the significance of apolipoprotein B (APO-B) in me...
Aug 05, 2024•19 min
Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each.
Jul 29, 2024•28 min
Buck interviews Dr. Ken Frumkin on his own journey of aging and cognitive decline.
Jul 22, 2024•20 min
In this episode, Buck discusses gene editing and its potential implications for human health and longevity. He explains the basics of gene editing, including the structure of DNA and how genes are transcribed into proteins, then dives into the history and development of gene editing techniques, focusing on the game-changing CRISPR-Cas9 technology. He also explores the practical applications of gene editing, such as its use in treating sickle cell anemia and other genetic diseases, as well as the...
Jul 15, 2024•27 min
Topics include: 00:25 Protein Intake for Longevity 12:40 Tips to Improve Sleep Quality 22:52 Is Robert F. Kennedy Jr. Controlled by a Worm
Jul 08, 2024•30 min
Topics include: 00:40 Is Weightloss Simply Calories In and Out? 07:10 Stem Cell Injections for NBA Players? 14:60 Statins for Lowering Cholesterol 23:19 The Impact of Nature and Nurture on Longevity
Jul 01, 2024•33 min
Buck Joffrey, MD discusses the concept of resilience with Stephen Sideroff, PhD. Topics include bouncing forward from stress and practical techniques to restore balance, nurture growth, and slow down the aging process. 01:35 Defining Resilience and the Ability to Adapt 08:21 Physical Balance and Mastery: Restoring Balance in the Nervous System 15:26 Self-Relationship: How It Changes Your Physiology 21:47 Resilience and Longevity 23:16 Emotion Balance and Mastery...
Jun 24, 2024•29 min
I've been hearing about stem cells for decades. When I was a medical student going into neurosurgery, I seriously considered focusing my research on neuroregeneration with stem cells. As it turns out, few advancements were made in that arena for many years until Hans Keirstead and his team did some groundbreaking work on quadriplegics. Now Hans is focused on longevity. Hans may have found a new type of treatment for what I call inflammaging. His company, Immunis, isolates various proteins and gr...
Jun 17, 2024•55 min
