144: Why the Brain is Especially Vulnerable to Aging

In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain.

They discuss the brain’s heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier.

The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions.

Dr. Andersen also underscores the critical role of lifestyle interventions—especially exercise—in maintaining brain health.

Learn more about Dr. Julie Andersen and the Buck Institute:

https://www.buckinstitute.org/lab/andersen-lab/

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