141: A Thermostat for Your Body Fat
Jun 23, 2025•29 min
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Episode description
In this conversation, Dr. Stephan J. Guyenet joins Dr. Buck Joffrey to discuss the complex mechanisms of body fat regulation, focusing on the role of the lipostat and leptin. He explains how the body regulates fatness through hormonal signals and the implications of leptin resistance in obesity. The discussion also covers practical strategies for weight management, the impact of stress and sleep on leptin levels, and critiques of the carbohydrate insulin model of obesity. Learn more about Dr. Stephan J. Guyenet: https://www.stephanguyenet.com/
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