Episode description
Episode description
Join us on this podcast episode featuring Prof Domenico Girelli, Professor of Internal Medicine and Director of the Internal Medicine Unit, University Hospital of Verona (Italy), as he discusses the latest advances on the use of Hepcidin mimetics in the treatment of Polycythemia Vera and iron metabolism diseases.
Discover how Hepcidin analogues offer a precise method for managing the overproduction of red blood cells in Polycythemia Vera patients. Explore the potential of Rusfertide, an inhibitor of Hepcidin, in regulating iron availability for erythropoiesis, thereby addressing the characteristic and chronic erythrocytosis seen in Polycythemia Vera. Gain insights into how targeting the Hepcidin-Ferroportin axis is revolutionizing the treatment of various iron metabolism disorders.
Tune in for a comprehensive discussion on these groundbreaking advancements in hematology research.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Domenico Girelli
This is the second in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
To go further: Kremyanskaya M et al. Rusfertide, a Hepcidin Mimetic, for Control of Erythrocytosis in Polycythemia Vera. N Engl J Med. 2024 Feb 22;390(8):723-735. doi: 10.1056/NEJMoa2308809. PMID: 38381675.
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