Tune in to our podcast for an in-depth discussion on CAR T-cell therapy for acute lymphocytic leukemia (ALL) in children. In this episode, we feature Professor Concetta Quintarelli, a renowned expert in hematology from the Bambino Gesù Children Hospital in Rome. With host Isabel Olivera, they explore the advancements and challenges in treating ALL with CAR T-cells, the balance between treatment efficacy and safety, and the potential of combining CAR T-cells with other immunotherap...
Aug 09, 2024•19 min•Ep 109•Transcript available on Metacast Tune in to our podcast for an in-depth discussion on immunotherapeutic strategies for Acute Myeloid Leukemia (AML). In this episode, we feature Dr Sarah Tettamanti, a senior scientist at the Fondazione Tettamanti Research Centre in Italy, who shares her expertise on CAR T-cell therapy for AML. With host Dr Sarah de Vlieger, they examine the progress and challenges in treating AML with CAR T-cells, the balance between treatment efficacy and safety, and the potential of combining CAR T-cell...
Aug 02, 2024•15 min•Ep 108•Transcript available on Metacast Welcome to a thought-provoking episode of our podcast series, where we dive into the ethical and practical challenges of CAR T-cell therapy with Professor Marie José Kersten from Amsterdam University Medical Centers. In this episode, our host Dr Isabel Olivera engages in a deep dive with Professor Kersten on the intricacies of patient access to CAR T-cell therapy, the ethical considerations in patient selection, and the financial implications of this groundbreaking treatment. Discover the rigoro...
Jul 26, 2024•22 min•Ep 107•Transcript available on Metacast Join us for a conversation with Jonathan Clark, a patient advocate who has been in remission for over five years after receiving CAR T-cell therapy for Mantle Cell Lymphoma. Jonathan shares his journey from relapse to recovery, detailing the challenges and triumphs of this cutting-edge treatment from a patient’s perspective. With host Dr. Sarah de Vlieger, they discuss his motivation for sharing his story and the profound physical and psychological impacts of long-term remission. Jonathan also t...
Jul 19, 2024•12 min•Ep 106•Transcript available on Metacast Join us for a captivating interview with our guest Professor Michael Hudecek from the Universitätsklinikum Würzburg in Germany as he offers his insights on the latest advancements in CAR T-cell therapy and gene-engineered immune cell therapies. Together with our host Dr. Isabel Olivera Martinez, they discuss the mounting real-world data on CAR T-cell treatments and how AI is helping analyze this data to design new strategies and extend CAR-T to new indications. Discover the strides being m...
Jul 12, 2024•18 min•Ep 105•Transcript available on Metacast Join us on this podcast episode featuring Prof. Maria Teresa Voso (Tor Vergata University of Rome, Italy) as she offers her insights on the latest advancements in precision medicine for diagnosing and treating myelodysplastic syndromes (MDS). In this interview with our EHA host, Dr. Isabel Olivera Martinez, Prof. Voso begins by explaining how the use of NGS myeloid panels in identifying individual myeloid mutations enhances the diagnostic accuracy of MDS. Our guest then discusses the novel...
Jul 05, 2024•18 min•Ep 104•Transcript available on Metacast Join us for a stimulating conversation with our guest Dr. Eleni Gavriilaki, from G. Papanicolaou Hospital and Aristotle University of Thessaloniki in Greece, as she shares her insights on one of her passions: diversity, equity, and inclusion (DEI) in hematology. Together with our host Dr. Sarah de Vlieger, they discuss the current challenges of DEI in the field and how organizations like EHA are addressing these issues. They examine the importance of representation across gender, age group...
Jun 28, 2024•7 min•Ep 103•Transcript available on Metacast Join us for a captivating interview with our guest Professor Carl June, Director of the Centre for Cellular Immunotherapies at the University of Pennsylvania, USA, as he discusses the current directions in CAR T-cell therapy. Together with our host Dr. Sarah de Vlieger, they examine the latest results on both pediatric and adult patients with over ten years of follow up. They cover ongoing trials aimed at drastically reducing the vein-to-vein time for autologous CAR T-cells, as well as trends to...
Jun 21, 2024•14 min•Ep 102•Transcript available on Metacast Join us for a discussion with Prof Paolo Ghia, MD, PhD, from Università Vita Salute San Raffaele, Milan (Italy), as he explores how precision medicine is transforming CLL treatment. In this episode, discover how precision medicine is used daily in CLL to decide the best management and treatment for patients. Listen to Prof Ghia explain how CLL management is moving from traditional chemotherapy to targeted therapies based on specific genetic markers, like immunoglobulin mutational sta...
May 24, 2024•22 min•Ep 101•Transcript available on Metacast Join us on this podcast episode featuring Prof Lucia de Franceschi (Department of Medicine, University of Verona, Italy) as she discusses the latest advances on the use of Pyruvate kinase activators in the treatment of rare hematological diseases. Learn about the crucial role of Pyruvate kinase (PK) in erythrocyte metabolism and how pyruvate kinase activators are emerging as a new therapeutic option for chronic hemolytic anemias that had previously no other treatment than tran...
May 01, 2024•16 min•Ep 100•Transcript available on Metacast Join us for this captivating interview with our guest Prof Stefano Luminari, MD, PhD, from the University of Modena and Reggio Emilia in Italy, as he explores what precision medicine means today for follicular lymphoma. Together with our host Dr. Isabel Olivera-Martinez, they discuss the current precision medicine approaches to the diagnosis and treatment of follicular lymphoma. They explore the molecular events underlying the disease, the latest targeted therapies, and the future of treat...
Apr 26, 2024•20 min•Ep 99•Transcript available on Metacast Join us for a captivating discussion with Prof Pieter Sonneveld, MD, PhD, from Erasmus MC Cancer Institute in Rotterdam, the Netherlands, as he explores the evolution of precision medicine in multiple myeloma. Prof. Sonneveld outlines the improvements in multiple myeloma treatment over the past decade, describing the progressive addition of targeted therapies such as daratumumab and bispecific antibodies, BiTEs, and CAR-T cells to the therapeutic arsenal. Discover how treatment selec...
Apr 12, 2024•17 min•Ep 98•Transcript available on Metacast Welcome to this podcast episode featuring Prof Claire Harrison (Clinical Director at Guy’s and St Thomas’ NHS Foundation Trust) and Prof Jean-Jacques Kiladjian (Professor at Université Paris-Diderot and Hôpital Saint-Louis). Join them as they navigate the challenges and opportunities of precision medicine in MPNs, discover how advancements in molecular techniques are reshaping disease diagnosis, patient stratification and treatment tailoring. Gain insights into th...
Apr 05, 2024•13 min•Ep 97•Transcript available on Metacast Join us on this podcast episode featuring Prof Helen Papadaki (University of Crete, Greece) as she discusses the link between clonal hematopoiesis and the risk of developing MDS or AML. Prof. Papadaki begins by explaining the difference between CHIP (clonal hematopoiesis of indeterminate potential), CCUS (clonal cytopenia of undetermined significance) and ICUS (Idiopathic cytopenia of undetermined significance). She underlines the clinical relevance of the association of clonal hema...
Mar 29, 2024•24 min•Ep 96•Transcript available on Metacast Join us on this podcast episode featuring Prof Domenico Girelli, Professor of Internal Medicine and Director of the Internal Medicine Unit, University Hospital of Verona (Italy), as he discusses the latest advances on the use of Hepcidin mimetics in the treatment of Polycythemia Vera and iron metabolism diseases. Discover how Hepcidin analogues offer a precise method for managing the overproduction of red blood cells in Polycythemia Vera patients. Explore the potential of Rusfer...
Mar 15, 2024•19 min•Ep 95•Transcript available on Metacast Welcome to another season of EHA Unplugged. In our first episode of 2024, listen to Prof Carlo Dufour, Chairperson of the Paediatric Hemato-Oncology department of G. Gaslini Children’s Hospital in Genova (Italy), as he discusses how classical IBMFs (such as Fanconi Anemia, Diamond-Blackfan Anemia, Shwachman-Diamond Syndrome, and the telomere disorders) are now being joined by a large number of other diseases included in this category, thanks to the increasing precision of diagnostic genetic tool...
Feb 16, 2024•11 min•Ep 94•Transcript available on Metacast In this episode, join HemaSphere's editor-in-chief, Prof Jan Cools, as he guides you through article publishing. Acquire valuable insights, tips, and new perspectives on often-overlooked considerations. Prof Cools sheds light on the pivotal role of reviewers in the publishing process and provides his insights into the evolving impact of AI on publishing. Guest: Prof Jan Cools, KU Leuven. Belgium. Editor-in-Chief of HemaSphere Host: Dr Wilson Lim, European Hematology Association (EHA) Learn More ...
Dec 01, 2023•21 min•Ep 93•Transcript available on Metacast Welcome to EHA Unplugged! In this episode, join host Dr Wilson Lim as he delves into the world of hemochromatosis with esteemed Prof Domenico Girrelli from the University of Verona. Prof Girrelli provides valuable insights into the new classification of hemochromatosis, shedding light on its genetic determinants, clinical manifestations, and recent advancements in its diagnosis and treatment. Discover the complexities of iron metabolism and the impact of this classification on patient management...
Nov 17, 2023•17 min•Ep 92•Transcript available on Metacast In this episode Prof Tarec El-Galaly gives an overview of diversity, equity, and inclusion (DEI). He explains what is DEI in hematology and the work EHA taskforce DEI taskforce is doing for patients benefit. Listen to this great initiative and perhaps it can benefit your practice. Guest: Prof Tarec El-Galaly, Aalborg University Hospital, Denmark Host: Dr Wilson Lim, European Hematology Association (EHA) Learn More What did you think of this podcast? Share your opinions with us in this short feed...
Nov 10, 2023•9 min•Ep 91•Transcript available on Metacast Join us for this update on Autoimmune Neutropenia (AIN), a rare blood disorder that presents and develops differently in children and adults. Experts Dr Francesca Fioredda and Prof Helen Papadaki along with our host Dr. Isabel Olivera discuss the diagnostic challenges associated with AIN and the need for a broader definition, based on the latest insights from the different mechanisms underlying AIN’s pathogenesis. Learn how to adapt the...
Nov 03, 2023•21 min•Ep 90•Transcript available on Metacast Join us in this enlightening podcast as three experienced researchers, Dr Anastasia Conti, Prof Konstanze Döhner, and Dr Simona Valletta, delve into the dynamic world of scientific research. This discussion moderated by Prof Kirsten Grønbæk offers valuable insights into the pivotal aspects of successful careers in research for hematologists. The conversation dives deeply into topics relevant to aspiring and established researchers, such as the crucial role of mentorship, and the importance of f...
Oct 27, 2023•40 min•Ep 89•Transcript available on Metacast Join Prof Kirsten Grønbæk and Prof Konstanze Döhner as they talk about the current landscape in MDS. Prof Grønbæk shares her interest and passion in the disease, the challenges in diagnosis and treatment, and what is on the horizon in research and management of MDS. Guest: Prof Kirsten Grønbæk, Rigshospitalet and BRIC, Copenhagen, Denmark Host: Prof Konstanze Döhner, University Hospital of Ulm, Germany Learn More What did you think of this podcast? Share your opinions with us in this short feedb...
Oct 20, 2023•19 min•Ep 88•Transcript available on Metacast In this podcast, expert Prof Paresh Vyas and host Dr Enrica Orsini delve into the latest developments in the treatment of Acute Myeloid Leukemia (AML). They discuss new drug targets, new therapies in clinics and the impact of the new treatment on aging patients Moreover, they address existing challenges and provide a glimpse into what the future holds for AML treatment. Guest: Prof Paresh Vyas, University of Oxford, United Kingdom Host: Dr Enrica Orsini, EHA Learn More What did you think of this...
Oct 13, 2023•11 min•Ep 87•Transcript available on Metacast Join us for this insightful podcast where our experts Prof Kirsten Grønbæk, Dr Mirjam Belderbos, Dr Umut Yilmaz, and Prof Konstanze Döhner discuss their experiences, challenges, and strategies for thriving in their demanding and rewarding careers as hematologists. They share valuable insight from effective communication with patients and caregivers to coping with the emotional aspects of their work. Discover how they strike a balance between personal well-being and professional responsibilities....
Oct 09, 2023•35 min•Ep 86•Transcript available on Metacast Guest Prof Kimmo Porkka together with host Dr Enrica Orsini talk about using big data to build prognostic models. Based on Prof Porkka’s experience on working with big data, he uses the Harmony Alliance as an example and gives an overview of data collection, the importance of data security and the importance to have the participation of a large network of hospitals or academic centers, and recognising the challenges behind that. Guest: Prof Kimmo Porka. University of Helsinki, Finland Host: Dr E...
Sep 29, 2023•11 min•Ep 85•Transcript available on Metacast Prof Jorge Sierra provides an overview of myeloma, delving into its clinical aspects and sharing his personal passion for the disease. Together with host Prof. Konstanze Döhner, they explore myeloma's treatment challenges and advancements. Prof. Sierra also offers valuable advice on initiating myeloma research, making this an engaging podcast for students, trainees, and young hematologists alike. Guest: Prof Jorge Sierra Hospital de la Santa Creu i Sant Pau, Barcelona, Spain&nb...
Sep 22, 2023•24 min•Ep 84•Transcript available on Metacast In this episode, we talk to Dr. Umut Yilmaz from İstanbul University-Cerrahpaşa. Umut shares his interest in lymphoma, its diversity, and the challenges in his work. He also offers unique advice for inspiring starting hematologists and calls for more people to join the exciting field of lymphoma research and treatment. Guest: Dr Umut Yilmaz İstanbul University-Cerrahpaşa, Istanbul, Turkey Host: Prof Kirsten Grønbæk Rigshospitalet and BRIC, Copenhagen, Denmark...
Sep 15, 2023•14 min•Ep 83•Transcript available on Metacast Our guests Dr Anastasia Conti, Assoc Prof Maria Paola Martelli and Dr Simona Valletta give an overview on starting research in hematology. They go through their experience, give advice and talk about the challenges they face. The podcast starts with the basics of how to get started in hematology research, starting how to come up with research ideas and how to develop these ideas into projects. Our guests continue with their view on PhD programmes, where they give advice to those who want to star...
Sep 08, 2023•44 min•Ep 82•Transcript available on Metacast Listen as guest Dr Mirjam Belderbos talk to our host Prof Kirsten Grønbæk about her own experience in pediatric hematology, how she interacts with her patients and their family, the challenges in the field and how it differs from adult hematology. She also indulge us in the fun annual custom her pediatric unit does and how rewarding her role is to her. She ends by giving some advice to trainees and medical students who are interested in the field of pediatric hematology. Guest: Dr Mirjam Belderb...
Sep 01, 2023•17 min•Ep 81•Transcript available on Metacast This week, we have guest Prof Laura Silvestri from Vita-Salute San Raffaele University who gives an amazing overview of iron regulation from the perspective of the protein hepcidin. Prof Silvestri illustrates the mechanism behind hepcidin regulation and how is transcription effected by proinflammatory cytokines in certain hematological disorders. Host: Dr Enrica Orsini; Guest: Prof Laura Silvestri What did you think of this podcast? Share your opinions with us in this short feedback survey. Prov...
Aug 25, 2023•14 min•Ep 80•Transcript available on Metacast 
