In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron...
Jan 23, 2021•35 min•Ep. 710
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode President's science advisor to Cabinet (NY Times) Letter from Biden to Lander ( pdf ) Weekly flu (CDC)...
Jan 21, 2021•1 hr 30 min•Ep. 709
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times)...
Jan 17, 2021•2 hr 1 min•Ep. 708
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode J&J Ad26 vaccine phase 1/2 results (NEJM) SARS-CoV-2 encephalitis is a cytok...
Jan 16, 2021•40 min•Ep. 707
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse 2020 US traffic deaths (Car & Driver) National Vaccine Injury Compensation Program (HRSA) Jet injector (Wikipedia) Letters read on TWiV 706 Timestamps by Jolene . Than...
Jan 14, 2021•1 hr 36 min•Ep. 706
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Emily Travanty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode VOC detected in Colorado (WaPo) US has sequenced only 50,000 SARS-CoV-2 genomes (CDC) Huma...
Jan 10, 2021•1 hr 51 min•Ep. 705
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Argentine study on plasma therapy (NEJM) Ct values and clini...
Jan 09, 2021•32 min•Ep. 704
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position Follow authorize...
Jan 07, 2021•2 hr 5 min•Ep. 703
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse This little virus went ...
Jan 03, 2021•1 hr 37 min•Ep. 702
In Daniel Griffin's final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Attributes and predictors of long COVID-19 (medRxiv) Letters read on TWiV 701 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@mi...
Jan 02, 2021•39 min•Ep. 701
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position PHE update #2 ( pdf ) Sout...
Dec 31, 2020•2 hr 9 min•Ep. 700
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. Host: Vincent Racaniello Guests: Jonathan Auguste , Carol Blair , Desiree LaBeaud , Louis Lambrechts , and Mauricio Nogueira Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode RNAi in...
Dec 27, 2020•1 hr 27 min•Ep. 699
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Phased allocation of COVID-19 vaccines ( ACIP slides ) How CDC is making COVID-19 vaccine recommendations (CDC) Letters read ...
Dec 26, 2020•40 min•Ep. 698
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG...
Dec 24, 2020•2 hr 16 min•Ep. 697
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 lab...
Dec 20, 2020•2 hr 11 min•Ep. 696
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA EUA for Pfizer mRNA vaccine (FDA) Ellume at-home SARS-CoV-2 ant...
Dec 18, 2020•42 min•Ep. 695
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position TW...
Dec 17, 2020•1 hr 51 min•Ep. 694
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 laboratory assistant manager position FDA advisory committee votes in favor of EUA for Pfizer vaccine (NY Times) San...
Dec 13, 2020•1 hr 55 min•Ep. 693
Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mitigation strategies in early care and education settings (MMWR) WHO solidarity trial results (NEJM) Letters read on TWiV 692 Times...
Dec 11, 2020•38 min•Ep. 692
SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Laura Splan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this e...
Dec 10, 2020•2 hr 12 min•Ep. 691
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guest: Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NYC will create pandemic response institute (NY Bus J) Comparison of AC...
Dec 06, 2020•1 hr 59 min•Ep. 690
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vitamin D levels in COVID-19 patients (Nature) ACIP recommendations for distribution of COVID-19 vaccine (MMWR) Updated CDC guidance on when t...
Dec 05, 2020•37 min•Ep. 689
TWiV 688: We put COVID-19 papers through a sieve December 2, 2020 On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode UK grants EUA for Pfizer ...
Dec 03, 2020•1 hr 51 min•Ep. 688
Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Peter Hote z Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Peter Hotez on TWiP 29 and TW...
Nov 29, 2020•2 hr 18 min•Ep. 687
Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron's monoclonal antibody and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode WHO Solidarity trial for Remdesivir and other drugs (medRxiv) EUA for Baricitinib (FDA) EUA for Casirivimab and ...
Nov 28, 2020•34 min•Ep. 686
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a pat...
Nov 26, 2020•1 hr 50 min•Ep. 685
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Shane Crotty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA authorizes Lucira mini home testing kit ( FDA ) 60 day out...
Nov 22, 2020•3 hr 4 min•Ep. 684
On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Efficacy of Moderna and Pfizer mRNA vaccines Longer shelf life of Moderna vaccine (Moderna) Prothrombotic antibodies ...
Nov 19, 2020•1 hr 59 min•Ep. 683
From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv...
Nov 17, 2020•29 min•Ep. 682
Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Link...
Nov 15, 2020•2 hr 59 min•Ep. 681
