Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS. Hosts: Vincent Racaniello, Rich Condit , and Brianne Barker Guests: Mady Hornig , Fiona Lowenstein , and David Tuller Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Body Politic Survivor Corps Long-haulers redefining COVID-19 (Ed Yong) I'm 26. Coronavirus sent me to the hospital (Fiona Lowenstein) We need to talk about w...
Nov 12, 2020•1 hr 52 min•Ep. 680
Daniel Griffin provides a clinical report on COVID-19, Slovlakia's plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Amy Rosenfeld...
Nov 08, 2020•2 hr 37 min•Ep. 679
Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guest: Nels Elde Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Zebrafish virus discovery by visualization (Curr Biol)...
Nov 05, 2020•1 hr 51 min•Ep. 678
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Daniel's COVID-19 graph (Twitter) Cornell U containment victory (Bloomberg) Regeneron mAb trial paused ...
Nov 01, 2020•2 hr 41 min•Ep. 677
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Genome wide association study of severe COVID-19 (NEJM) Major genetic r...
Oct 29, 2020•2 hr•Ep. 676
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege's letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for th...
Oct 25, 2020•2 hr 54 min•Ep. 675
Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Me...
Oct 22, 2020•1 hr 59 min•Ep. 674
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Daniel's COVID-19 testing strategy calculator (and m...
Oct 18, 2020•2 hr 41 min•Ep. 673
Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Ari Kozik and Kishana Taylor Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patr...
Oct 15, 2020•2 hr 6 min•Ep. 672
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Hosts: Vincent Racaniello, Alan Dove , and Rich Condit Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASH guide...
Oct 11, 2020•2 hr 50 min•Ep. 671
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Kizzmekia Corbett Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for t...
Oct 08, 2020•2 hr 7 min•Ep. 670
Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Rethinking COVID-19 test sensitivity (NEJM) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv...
Oct 05, 2020•34 min
Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Michael B. Yaffe , and Christopher D. Barrett Subscribe (free): iTunes , Google Podcast...
Oct 04, 2020•3 hr•Ep. 669
Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Tony Schountz Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 infection of deer mice (bioRxiv) Infection of Jama...
Oct 01, 2020•1 hr 46 min•Ep. 668
Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Safety and immunogenicity of Russian COVID-19 vaccine (Lancet) 'Questionable' data ...
Sep 27, 2020•2 hr 45 min•Ep. 667
David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: David Brenner Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Far-UVC light inactivates viruses (paper one and two ) Tips to a...
Sep 24, 2020•2 hr 9 min•Ep. 666
Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Increased risk for COVID-19 du...
Sep 20, 2020•2 hr 56 min•Ep. 665
On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Coronavirus is mutating (Nature) Seasonal CoV immunity is short (Nat Med) Sorry, n...
Sep 17, 2020•2 hr 2 min•Ep. 664
Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Young adults with COVID-19 (JAMA) ...
Sep 13, 2020•2 hr 37 min•Ep. 663
The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses. Host: Vincent Racaniello Guests: Jane Flint , Anna Marie Skalka , Glenn F. Rall , and Theodora Hatziioannou Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Purchase PoV 5e Volumes 1 + 2 ( link ) Purchase PoV 5e Volume 1 ( link ) Purchase PoV 5e Volume 2 ( link...
Sep 11, 2020•52 min•Ep. 662
Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Broadly neutralizing sarbecovirus mAbs (bioRxiv) Evaluation of mRNA-1273 in nonhuman primates (NEJM) Bioavaila...
Sep 10, 2020•1 hr 56 min•Ep. 661
Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for th...
Sep 06, 2020•2 hr 39 min•Ep. 660
Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit , and Brianne Barker Guest: Christian Drosten Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Christian previously on TWiV 601 Plague percolation phenomenon (Nature) TMPRSS2 inhib...
Sep 03, 2020•2 hr•Ep. 659
Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email. Hosts: Vincent Racaniello, Alan Dove , Dickson Despommier , and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CDC told to soften SARS-CoV-2 t...
Aug 30, 2020•2 hr 21 min•Ep. 658
Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ahead of the Curve by Shane Crotty SARS-CoV-2 T cell epitopes (Cell) Cross-reactive CoV T cell epitopes (Science) Knowns and unknowns about SAR...
Aug 27, 2020•2 hr 13 min•Ep. 657
Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Lisa A. Smith , and W. David...
Aug 23, 2020•2 hr 21 min•Ep. 656
Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Robert Fullilove Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)<>Subscribe (free): iTunes , Google P...
Aug 20, 2020•2 hr 27 min•Ep. 655
Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Daniel's recommendations for COVID-19 testing ( pd...
Aug 16, 2020•2 hr 36 min•Ep. 654
Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic. Hosts: Vincent Racaniello and Rich Condit Guests: Alfonso Landeros , Ken Lange , Mary E. Sehl , and Janet Sinsheimer Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode School reopening strategies (medRxiv) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twi...
Aug 14, 2020•56 min•Ep. 653
Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Adam Kucharski Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The Rules of Contagion (Amazon affiliate link) Overdispersion in SARS-CoV-2 transmi...
Aug 13, 2020•1 hr 54 min•Ep. 652
