Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Denise Esposito Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Li...
Aug 09, 2020•2 hr 44 min•Ep. 651
In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Travis County indicators dashboard SARS-CoV-2 transmission at an overnight camp (MMWR) Ad...
Aug 06, 2020•2 hr 2 min•Ep. 650
Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses. Host: Vincent Racaniello Guests: Shan-Lu Liu , David Bisaro , Amanda Panfill , Mark Peeples , Matt Sullivan , Chris Walker , Qiuhong Wang Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode New vi...
Aug 04, 2020•1 hr 45 min•Ep. 649
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email ...
Aug 02, 2020•2 hr 55 min•Ep. 648
In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children do transmit infection (Emerg Inf Dis) NIH RADx initiative (NEJM) Rockefeller Foundation testing plan HCQ observation...
Jul 30, 2020•1 hr 54 min•Ep. 647
From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses. Hosts: Vincent Racaniello and Rich Condit Guest: Eugene Koonin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Virocentricity with Eugene Koonin ( TWiV 275 ) Origin of viruses (Nat Rev) Multiple origins of capsid proteins from cells (PNAS) Origins and evolution of global RNA virome (mBio) Evo...
Jul 28, 2020•1 hr 56 min•Ep. 646
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode State Dept. memo on Wuhan BSL-4 lab ( pdf ...
Jul 26, 2020•2 hr 43 min•Ep. 645
In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Click arrow to play Download TWiV 644 (69 MB .mp3, 115 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! L...
Jul 23, 2020•1 hr 55 min•Ep. 644
From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses. Hosts: Vincent Racaniello and Rich Condit Guest: Bernie Moss Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Link for this episode Reflections on Bernie Moss' career (JBC) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv...
Jul 21, 2020•1 hr 52 min•Ep. 643
Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Travis County virtual Town Hall SARS-CoV-2 mR...
Jul 19, 2020•2 hr 40 min•Ep. 642
Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness. Hosts: Vincent Racaniello and Rich Condit Guest: Dr. Anthony Fauci Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Dr. Fauci was previously on TWiV 219 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv...
Jul 17, 2020•36 min•Ep. 641
Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guests: Michael Mina Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Michael Mina on Immune 26 White House bypasses CDC (NY Times) Test sensitivity is secondary to frequency ...
Jul 16, 2020•1 hr 46 min•Ep. 640
Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV-1, human papillomaviruses and much more. Host: Vincent Racaniello Guest: Erling Norrby Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Nobel Prizes and Life Sciences by Erling Norrby Nobel Prizes and Nature's Surprises by Erling Norrby Nobel Pri...
Jul 14, 2020•1 hr 48 min•Ep. 639
Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guests: Viviana Simon , Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Serological assay for SARS-CoV-2 infection (Nat Me...
Jul 12, 2020•2 hr 44 min•Ep. 638
In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode China approves COVID-19 vaccine for military (CNN) Ad5-vector...
Jul 09, 2020•1 hr 49 min•Ep. 637
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development. Host: Vincent Racaniello Guests: Chris Basler , Andrew Gewirtz , Priya Luthra , and Richard Plemper Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mutant Ebolavirus lacks virulence (Cell Rep) Blocking Ebolavirus replication by depleting nucleoside pools (Antivir...
Jul 07, 2020•1 hr 53 min•Ep. 636
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Infectious SARS-CoV-2 in nasopha...
Jul 05, 2020•2 hr 33 min•Ep. 635
TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode New swine flu with pandemic potential ( BBC , PNAS ) Oral SARS-CoV-2 vaccine candidate (...
Jul 02, 2020•2 hr•Ep. 634
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host: Vincent Racaniello Guests: Sheemei Lok , Dahai Luo , Eng Eong Ooi , and Ashley St. John Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Dengue virus and endothelial permeability (J Clin Invest) Dengue virus morphological switch (PLoS Path) Symptomatic yellow fever vaccin...
Jun 30, 2020•1 hr 33 min•Ep. 633
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Dexamethasone for COVID-19 (medRxiv) Proning trial for COVID-19 (Lancet) Tocilizuma...
Jun 28, 2020•2 hr 24 min•Ep. 632
Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Hosts: Vincent Racaniello, Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Probability of symptoms and severe COVID-19 (aRxiv) Cellular immune response without seroconversion...
Jun 25, 2020•1 hr 59 min•Ep. 631
From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission. Host: Vincent Racaniello Guest: Lee Ching Ng Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV!...
Jun 24, 2020•49 min•Ep. 630
Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email. Hosts: Vincent Racaniello, Dickson Despommier , and Alan Dove Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode...
Jun 21, 2020•2 hr 38 min•Ep. 629
Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Austin TX key indicators for staging D614 amino acid change (Scripps) Virus shedding in hospitalized patients (medRxiv) Ha...
Jun 18, 2020•1 hr 53 min•Ep. 628
Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore. Host: Vincent Racaniello Guests: Leo Yee-Sin and Nancy Tee Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode National Centre for Infectious Diseases National Public Health Laboratory Intro music is by Ronal...
Jun 17, 2020•1 hr 31 min•Ep. 627
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Mouse-adapted SARS-CoV-2 model (bioRxiv) SARS-...
Jun 14, 2020•2 hr 43 min•Ep. 626
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field. Hosts: Vincent Racaniello and Rich Condit Guest: Frederick A. Murphy Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Link for this episode (UTMB) Intro music is by Ronald Je...
Jun 11, 2020•1 hr 40 min•Ep. 625
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Sabra Klein Click arrow to play Download TWiV 624 (91 MB .mp3, 152 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this epi...
Jun 07, 2020•2 hr 3 min•Ep. 624
Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Peter Daszak Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bats are reservoirs of SARSr-CoV (Scienc...
Jun 04, 2020•1 hr 22 min•Ep. 624
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remde...
Jun 02, 2020•1 hr 8 min•Ep. 622
