Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for an...
Oct 12, 2014•1 hr 48 min
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this...
Oct 05, 2014•1 hr 33 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Jeff Shaman The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing...
Sep 28, 2014•1 hr 38 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an intere...
Sep 21, 2014•1 hr 33 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68. Links for this episode Cancer patient saved by measles virus Ebola virus genome sequences (Science) Robert Garry on Ebola outbreak Aerosol transmission WHO Ebola outbreak summary CDC Ebola outbreak page Ebola outbreak epi curve CED Ebola outbreak info graphic E...
Sep 14, 2014•1 hr 53 min
Host: Vincent Racaniello Guests: Carla Saleh and Curtis Suttle At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth. Links for this episode Greatest biodiversity on Earth (Genome) Cafeteria roenbergensis virus (PNAS) Marine viruses (Nat Rev Micro) RNAi and reverse transcription is antiviral in flies (Nat Imm) Friendly persist...
Sep 06, 2014•1 hr 24 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Recording together for the first time, the TWiV team celebrates their 300th recording at the American Society for Microbiology headquarters in Washington, DC, where Vincent speaks with Dickson, Alan, Rich, and Kathy about their careers in science. Links for this episode So Happy Together (The Turtles) Viral Hemorrhagic Fever Consortium Support Kenema VHFC program Letters read on TWiV 298 Video of this e...
Aug 31, 2014•1 hr 33 min
Host: Vincent Racaniello Guests: Marshall Bloom , Sonja Best , and Byron Caughey Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases. Links for this episode Rocky Mountain Laboratories , NIH Flavivirus persistence (Path Dis) Flaviviruses antagonize IRF1 (J Imm) Prion test using nasal brushings (NEJM) Video of this episode - view at YouTube Send your virology ...
Aug 24, 2014•1 hr 27 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiV gang answer follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of disseminated multiple myeloma with oncolytic measles virus. Links for this episode Use of unregistered interventions for Ebola virus disease (WHO) Response to anthrax and H5N1 incidents (CDC) Remission of disseminated cancer after treatment with oncolytic measles virus (Mayo Clin Proc) New viruses for cancer the...
Aug 17, 2014•1 hr 46 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline. Links for this episode Risks and benefits of gain-of-function experiments (mBio) Scientists for Science US Policy for oversight of DURC (pdf) US framework for guiding H5N1 transmission expts (pdf) Extra oversight for H7N9 experiments (Science) TWiV 283: No Reston for the weary Is i...
Aug 10, 2014•1 hr 55 min
Host: Vincent Racaniello Guest: Linfa Wang Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses. Links for this episode Hendra virus vaccine (Emer Inf Dis) Comparison of bat genomes (Science) Endogenous retroviruses in bats (Retrovirol) The Bat Pack Bats in Geelong (YouTube) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv...
Aug 03, 2014•1 hr 2 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry. Links for this episode miRNA strategy to minimize risk (Nat BioT) NIH Office of Science Policy NIH recombinant DNA guidelines Second receptor for Lassa virus entry (Science) Lassa fever (Wikipedia) Fever! The discovery of Lassa virus ( TWiV 9 ) Letters read o...
Jul 27, 2014•1 hr 48 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members. Links for this episode Newly discovered smallpox (CDC) Infectious smallpox in FDA storage (FDA) Report on potential anthrax exposure (pdf, CDC) CDC Director on unsafe practices (NY Times) HIV returns to baby (NY Times) O...
Jul 20, 2014•1 hr 39 min
Host: Vincent Racaniello Guests: Melissa Churchill , Alex Khromykh , Gilda Tachedjian , and Paul Young Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus. Links for this episode Where does HIV hide ? (Curr Op HIV AIDS) Subgenomic flavivirus RNA (Viruses) Vaginal lactic acid and HIV (J Antimicro Chem) Koala retroviruses (Retrovirology) Co...
Jul 13, 2014•1 hr 33 min
Host: Vincent Racaniello Guests: Wade Blair, Matt Dickson, Nicole Kallewaard-Lelay, and Ken Miller Vincent visits Medimmune and speaks with Wade, Matt, Nicole, and Ken about why they work in industry and their daily roles in a biotechnology company. Links for this episode Medimmune, LLC Medimmune on Twitter Medimmune history and products Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv...
Jul 06, 2014•1 hr 13 min
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Clodagh O'Shea and Ron Fouchier Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado. Links for this episode Viral polymer that inactivates tumor suppressors (Cell) Mutations driving airborne transmission of influenza H5N1 virus (Cell) Transmission of influenza H7N1 virus in ferrets (J...
Jun 29, 2014•1 hr 6 min
Host: Vincent Racaniello Guests: Janet Butel and Rick Lloyd Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress. Links for this episode SV40 microRNAs (PLoS Path) SV40 seroprevalence (J Infect) Viruses and stress granules (PLoS Path) Viral inhibition of stress granule formation (Cell Host Micr) Video of this episode - view below or at YouTube Send your virology questions and comments (email or mp3 file...
Jun 18, 2014•1 hr 28 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more. Links for this episode Varun's research poll Letters read on TWiV 289 Weekly Science Picks Alan - The Science of Good Cooking Vincent - The Shooter Report (pdf) Kathy - Daily overview Dickson - Girl rising Listener P...
Jun 15, 2014•1 hr 41 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells. Links for this episode Should variola virus be destroyed ? (poll at virology blog) DNA complementary to non-retroviral RNA viruses (Sci Rep) Integration of arenavirus DNA into cell genome (virology blog) Infectious respiratory syncytial DNA (PNAS) Tysabri and PML JC and ...
Jun 08, 2014•2 hr
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Matt Frieman Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens. Links for this episode MERS stories at CIDRAP MERS at CDC MERS in the US (CDC) MERS-CoV map MERS-CoV infection after camel exposure (EID) MERS-CoV in dromedaries from Egypt, Sudan, Ethiopia (EID) MERS-CoV antivirals ( one , two , three , four ) Expe...
Jun 01, 2014•1 hr 48 min
Hosts: Vincent Racaniello and Alan Dove Guests: Julie Pfeiffer and Paul Duprex Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus. Links for this episode Threading the NEIDL (YouTube) Transmission of measles virus from macaques (J Gen Virol) Tropism of green measles virus in macaques (J Virol) Intestinal microbiota promote enteric virus replication (Sc...
May 26, 2014•1 hr 34 min
Host: Vincent Racaniello Guests: XJ Meng and Sarah McDonald Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses. Links for this episode Hepatitis E virus (Int J Env Res Pub Health) Porcine and human anelloviruses (J Virol) Origin of porcine epidemic diarrhea virus in US (mBio) Distinguishing rotaviruses (J Virol) Molecular epidemiology of rotaviruses (J Virol) Core domains in rotavirus polymerase encapsidation (J Gen Virol) Send your v...
May 17, 2014•1 hr 28 min
Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed. Links for this episode Skin scarification protects against vaccinia virus disease (J Virol) Smallpox research agenda (PLoS Path) WHO report on variola research (pdf) Review of smallpox research program for WHO (pdf) How I record my lectures (virology blog) Letter...
May 11, 2014•1 hr 43 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jens H. Kuhn Jens speaks with the TWiV team about filoviruses, including the recent Ebola virus outbreak in Guinea. Links for this episode Review of Zanamavir clinical trials (Brit Med J) Ebola virus disease in Guinea (NEJM) Filovirus nomenclature (virology blog) Ebola virus disease, West Africa (ProMedMail) How lethal are ebolaviruses? (virology blog) Letters read on TWiV 283 Weekly Science Picks Alan - AMNH digital...
May 04, 2014•1 hr 50 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws. Links for this episode World Malaria Day Review of oseltamivir clinical trials (Brit Med J) Effectiveness of Tamiflu questioned (NHS choices) Tamiflu campaign (Brit Med J) Rescuing US biomedical research (PNAS) Letters read on TWiV 282 Weekly Science...
Apr 27, 2014•1 hr 44 min
Host: Vincent Racaniello Guest: Peter L. Salk Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk's 100th birth anniversary. Links for this episode Jonas Salk Legacy Foundation The Cutter Incident by Paul Offit Splendid Solution by Jeffrey Kluger ( review ) Coming soon: Video of this episode Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv...
Apr 21, 2014•1 hr 31 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVmeisters answer listener email about the NEIDL, negative results, patenting MERS-coronavirus, human papillomavirus transmission, canine distemper virus, and much, much more. Links for this episode Poxvirus viability in historical relics (EID) TWiM 74 : It came from the Siberian permafrost How to read a scientific paper Image credit: Not only quilts Letters read on TWiV 280 Weekly Science Picks A...
Apr 13, 2014•1 hr 39 min
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body. Links for this episode Retrovirus needed for stem cell identity (Nat Struc Mol Biol) HERV-H is a marker for pluripotency (Retrovirology) Letters read on TWiV 279 Weekly Science Picks Alan - Heathkit Vincent - How to think about autism risk and Autism prevalen...
Apr 06, 2014•1 hr 30 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1. Links for this episode Gene editing of ccr5 in AIDS patients (NEJM) HIV gets the zinc finger (TWiV 144) Genome engineering with zinc finger nucleases (Genetics) Photo credit: Watty's Wall Stuff Mice lie, monkeys exaggerate t-shirt design (thanks, Christophe) Letters read on TWiV 278 Weekly Science Pic...
Mar 30, 2014•1 hr 43 min
Hosts: Glenn Rall , Ann Skalka , and Vincent Racaniello Glenn and Ann meet up with Vincent to talk about his career in science and science communication. Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv...
Mar 23, 2014•1 hr 18 min
