Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids. This episode is sponsored by @ASM Conferences and ASM Microbe Links for this episode Life threatening influenza and IRF7 deficiency (Scien...
May 10, 2015•1 hr 40 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants. This episode is sponsored by ASM Microbe and ICAAC/ICC Links for this episode Possible sexual transmission of Ebolavirus (MMWR) Ebolavirus whole-virus vaccine pro...
May 03, 2015•1 hr 50 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget. This episode is sponsored by SciMed Solutions and ASM Education . Links for this episode Pinot noir and viruses (Wine Spectator) 35:00 Endogenous florendoviruses (Nat Commun) 35:30 Sex and Ebolavirus transmission ( WHO , CDC , NYTimes ) 54:...
Apr 26, 2015•1 hr 36 min
Host: Vincent Racaniello Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program. Links for this episode MTGR1 and intestinal secretory lineage allocation (Faseb J) Coronaviruses induce macropinocytosis (mBio) PD-1 and respiratory virus reinfection (J Immunol) Vanderbilt MSTP on Facebook Video of this episode: view at YouTube S...
Apr 19, 2015•1 hr 34 min
Host: Vincent Racaniello Guests: Seth Bordenstein , James Crowe , and Mark Denison Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses. Links for this episode SARS-CoV error correction (PLoS Path) 19:00 Marburg virus neutralization by a human antibody (Cell one and two ) 56:35 Phage WO , Wolbachia and Drosophila (Peer J) 1:02:00 Seth's blog Symbionticism 1:31:30 Seth on Twitter Video...
Apr 12, 2015•1 hr 37 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease. This episode is sponsored by SciMed Solutions and ASM Education . Links for this episode Clusters of AFP associated with enterovirus D68 (Lancet) 31:35 Novel outbreak enterovirus D68 strain (Lancet Inf Dis) 53:00 Enterovirus D68 in Norway (Euro Surveill) 1:12:00 Unknown enemy (Nature) ...
Apr 05, 2015•2 hr 16 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes. Links for this episode NYAS Afterschool STEM Mentoring Program Concerns about editing the human germline ( Science , Nature ) Engineering the perfect baby (MIT Tech Rev) RNA recognition by HCV polymerase (Science) Kickstarting an RNA polymerase (Science) A protein platform f...
Mar 29, 2015•1 hr 51 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection. Links for this episode Immune signatures in ME/CFS (Science Adv) 11:15 Systemic exertion intolerance disease (Lancet) 19:50 Cell nuclease controls anti-viral responses (Cell Host Micr) 25:10 Poxvirus decapping enzymes prevent innate respon...
Mar 22, 2015•1 hr 50 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing. Links for this episode Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path) Prp8 protein of the spliceosome (RNA) Nuclear entry of poliovirus RdRp (Virol) RNA processing (TWiV 216) Measles in USA (CDC) Principles of Microbial Diversity Journal of Microbio...
Mar 15, 2015•1 hr 32 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas. Links for this episode Traces of ATCV-1 associated with laboratory contamination (PNAS) ATCV-1 findings not explained by contamination (PNAS) Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS) INNO-LIA Principles of Microbial Diversity I...
Mar 08, 2015•1 hr 43 min
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles. Links for this episode Dif-tor heh smusma (NY Times) Immunization preterm premature infants (Thanks, Johnye!) HIV and SHIV protection conferred by eCD4-Ig (Nature) Tyrosine sulfation (Wikipedia) GBV-C and Ebolavirus infection (J Virol) Letters read on TWiV 326 Weekly Science Picks Alan - Toms River b...
Mar 01, 2015•1 hr 33 min
Host: Vincent Racaniello Guests: Rollie Clem and Lorena Passarelli Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses. Links for this episode Apoptosis inhibition in A. aegypti (Apop) Initiator caspase in armyworm (Insect Bioc Mol Biol) Manipulating apoptosis in A. aegypti (J Virol) Viral inhibitors of apoptosis (Sem Cell Dev Biol) Baculoviruses: Sophisticated pathogens (PLoS Path) Baculovirus morphogenesis (Virol) Barr...
Feb 22, 2015•1 hr 22 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Lee Feinman Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus. Links for this episode Spin by Robert Charles Wilson Immunization of preterm infants (Dev Period Med) miR-122 alters HCV translation-replication balance (Cell Host Micr) Holding a miR to HCV (TWiV 180) Treating hepatitis C by blocking miR...
Feb 15, 2015•1 hr 56 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The family TWiVidae discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis. Links for this episode Enteric virome changes in inflammatory bowel disease (Cell) Gov. Christie stumbles on vaccination (NY Times) Anti-vax psychology (NPR) Vaccine skeptic changes her mind (NPR) Ebolavirus sitrep (WHO) Letters read on TWiV 323 Weekly Science Picks Alan - Sitesucker Rich - Snake pick...
Feb 07, 2015•1 hr 45 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more. Links for this episode Bourbon virus (NY Times) Thogotovirus (ViralZone) Drug induced apoptosis and HIV infection (PLoS One) Mumps cases and outbreaks (CDC) Opossums as pets? (doc) Cat found Letters read on TWiV 322 Weekly Sci...
Feb 01, 2015•1 hr 47 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Paul Duprex Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis. Links for this episode Wain-Hobson objects ( one , two , three , four ) Influenza H7N1 transmission experiments (J Virol) Epistemological perspective on aTRIP experiments (mBio) Limited scientific value and risk (mBio) Reply to limited...
Jan 25, 2015•1 hr 41 min
Host: Vincent Racaniello Guest: John Coffin Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries. Links for this episode John Coffin (Wikipedia) Specific HIV integration sites (Science) Novel retrovirus in modern birds (J Virol) Recombinant origin of XMRV (Science) Cranberry harvest (jpg) Send your virology question...
Jan 17, 2015•1 hr 52 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America. Links for this episode Efficacy of dengue vaccine (NEJM) Preventing dengue (NEJM) Dengue viruses (Scitable) Intention to treat (Wikipedia) Image credit: Jean-Yves Sgro Letters read on TWiV 319 Weekly Science Picks Alan - The Toaster Project by Thomas Thwaites Rich - Spa...
Jan 11, 2015•1 hr 42 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014. Ten virology stories of 2014 Ebola virus outbreak (TWiV 314 , 309 , 308 , 307 , 306 , 305 , 304 , 303 , 302 , 298 , 297 , 283 ) Directional uncoating of rhinovirus RNA (TWiV 267 ) Pandemic pathogen controversy (TWiV 287 ) Viral evolution (TWiV 275 ) Borna virus inhibition by endogenous DNA (TWiV 303 ) MERS-CoV in dromedary camels (TW...
Jan 04, 2015•2 hr
Host: Vincent Racaniello Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science. Video of this episode: view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv...
Dec 28, 2014•1 hr 25 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis. Links for this episode IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS) Th17 cells involved in influenza mediated gut injury (J Exp Med) Helper T cells 2014-15 flu season (CDC) Key facts about flu & flu vaccine (CDC) Does the flu vaccine work ? (Turbid plaque) Effectiveness o...
Dec 21, 2014•1 hr 31 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions. Links for this episode National Influenza Immunization Week (CDC) Densovirus associated with sea star wasting disease (PNAS) A virus that melts sea stars (virology blog) Chlorovirus in human oropharynx (PNAS) Algal virus in humans (virology blog)...
Dec 13, 2014•1 hr 27 min
Host: Vincent Racaniello Guests: Kartik Chandran , Ganjam Kalpana , and Margaret Kielian Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells. Links for this episode Antibodies that protect against Sudan virus (ACS Chem Biol) Ebola virus entry requires NPC1 (EMBO J) A toggle switch for virus entry (Na...
Dec 07, 2014•1 hr 27 min
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome. Links for this episode Ebola virus update (WHO) Norovirus can replace functions of gut microbiome (Nature) Post-vaccinal distemper encephalitis (N Z Vet J) Novel sea otter poxvirus (J Wildl Dis) Poliovirus escapes antibodies (virology blog) CDC whistleblower saga (Sci Based Med) Snopes on CDC whistleblower Image credit Letters r...
Nov 30, 2014•1 hr 38 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this de...
Nov 23, 2014•1 hr 33 min
Host: Vincent Racaniello Guests: Zhen Fu and Biao He Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses. Links for this episode Blood-brain permeability and rabies survival (Antiviral Res) Rabies induces blood-brain permeability (J Virol) Virus neutralizing antibodies in CNS of non-lethal rabies (PLoS Neg Trop Dis) RSV vaccine based on PIV5 (Vaccine) New mumps vaccine (J Virol) PIV5-based influenza virus vaccine ...
Nov 16, 2014•1 hr 16 min
Hosts: Vincent Racaniello and Glenn Rall Guest: Ann Skalka Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses. Links for this episode Skalka laboratory Asilomar Conference on recombinant DNA Unexpected inheritance (PLoS Path) Viral sequences in vertebrate genomes (J Virol) Assembly of integrase multimers (J Biol Chem) Cell cycle and retrovirus integration (J Cell Bioch) Video of this episode - vi...
Nov 09, 2014•59 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an ...
Nov 02, 2014•1 hr 59 min
Host: Vincent Racaniello Guest: Tom Solomon Tom talks with Vincent about viral central nervous system infections of global importance, Ebola virus, and running the fastest marathon dressed as a doctor. Links for this episode World's biggest brain Tom's YouTube channel Sex, drugs, and emerging viruses (TedX) The Running Mad Professor Image credit: ClickLiverpool Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv...
Oct 25, 2014•1 hr 24 min
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Guest: Tara C. Smith Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit ...
Oct 19, 2014•1 hr 37 min
