Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM. Hosts: Vincent Racaniello , Elio Schaechter, and Michael Schmidt . Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Cryo-EM of viruses and vaccine design (PNAS) Atomic structure of rhinovirus C (PNAS) Opening wi...
Aug 20, 2016•1 hr 1 min
Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires. Hosts: Vincent Racaniello , Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Cell division by longitudinal scission (mBio) Bacterium learns long division (STC) Charge transport by microbial ...
Aug 05, 2016•57 min
Hosts: Vincent Racaniello and Michael Schmidt Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology , and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice. Links for this episode Protein secretion in E. coli (J Bacteriol) Plague pathogenesis (J Bacteriol) Reversal of diet induced social defects (Cell) Letters read on TWiM 131 This episode is brought to you by CuriosityStream, a subscript...
Jul 20, 2016•1 hr 22 min
Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.
Jun 23, 2016•1 hr 17 min
The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele. Image: Etest used to determine the minimum inhibitory concentration of an antibiotic for a particular bacterium. Hosts: Vincent Racaniello , Michael Schmidt , and Michele Swanson. Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You c...
Jun 07, 2016•1 hr 11 min
A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode. Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts. Hosts: Vincent Racaniello , Elio Schaechter, Michele Swanson , and Michael Schmidt . Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for ...
May 21, 2016•1 hr 18 min
The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease. Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent and orange floc on the seafloor. Credit: Canadian Scientific Submersible Facility and the University of Washington Hosts: Vincent Racaniello , Elio Schaechter, Michele Swanson , and Michael Schmidt . Subscribe to TWi...
May 05, 2016•54 min
The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele. Hosts: Vincent Racaniello , Michele Swanson , and Michael Schmidt . Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Microbiome of hibernating brown bear and energy metabolism (Cell Rep) Ten animals that hibernate (Con...
Apr 22, 2016•1 hr 7 min
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this episode of TWiM. Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Culture-independent surveillance of probiotics (mSphere) Design and synthesis...
Apr 07, 2016•58 min
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity. Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Michele on Flint Legionella outbreak (Detroit News) Fungal mimicry of a mammalian aminopeptidase (Cell Host Micr) This episode is sponsored by ASM Agar Ar...
Mar 24, 2016•1 hr 3 min
Hosts: Vincent Racaniello , Michael Schmidt , and Elio Schaechter. Guest: Harris Wang Harris joins Vincent, Elio, and Michael to describe multiplex automated genome engineering, a method for targeting many modifications in a population of bacterial cells. Subscribe to TWiM (free) on iTunes , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode MAGE - Multiplex automated genome engineering (Nature) Genome-scale promot...
Mar 09, 2016•1 hr 15 min
Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome. Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Identification of a novel Borrelia species causing Lyme disease (Lancet Inf Dis) Parasite wonders with Bobbi Pritt (TWiP 75) Reported cases of Lyme disease (CDC) Signs and symp...
Feb 25, 2016•1 hr 4 min
Host: Vincent Racaniello Special guests: Rebekah Kading and Wyndham Lathem From the ASM Biodefense and Emerging Diseases Research meeting, Vincent speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague. Subscribe to TWiM (free) on iTunes , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episo...
Feb 11, 2016•58 min
Hosts: Vincent Racaniello and Elio Schaechter. Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease. Subscribe to TWiM (free) on iTunes , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Tubeworm metamorphosis by phage tail-like structures (Science) Cell enzyme becomes viral cap...
Feb 02, 2016•49 min
Hosts: Vincent Racaniello , Michael Schmidt , and Elio Schaechter. The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis. Subscribe to TWiM (free) on iTunes , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Revised estimates of human and bacterial cells in the body (biorxiv) Power of ten (Small Things ...
Jan 16, 2016•1 hr 3 min
Hosts: Vincent Racaniello , Elio Schaechter and Michele Swanson On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers. Subscribe to TWiM (free) on iTunes , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Pack hunting by a common soil amoeba on nematodes (Environ Micro) Mushrooms as rainmakers (PLoS One) Mushroom by Nichol...
Jan 01, 2016•1 hr 6 min
The TWiM team marvels over the finding of a completely nitrifying Nitrospira , and horizontal gene transfer from Wolbachia into an animal genome. Links for this episode: Complete nitrification by Nitrospira bacteria (Nature one , two ) Enigmatic comammox (PhysOrg) Ammonia-oxidizing bacteria (Ann Rev Micro) Tardigrade controversy (SciAlert) Horizontal gene transfer from Wolbachia to grasshopper (PeerJ) Thumbnail Image (nitrogen cycle) credit Letters read on TWiM 117 This episode is sponsored by A...
Dec 17, 2015•1 hr 10 min
Hosts: Vincent Racaniello , Elio Schaechter and Michele Swanson The TWiMeriti reveal a Brazilian social bee that must cultivate a fungus to survive, and diet-mediated reduction in gut colonization by Candida albicans . Links for this episode Bee cultivates fungus to survive (Curr Biol) Diet reduces C. albicans gut colonization (mSphere) mSphere , a new open-access ASM journal Image credit Letters read on TWiM 116 This episode is sponsored by ASM Biodefense and the 32nd Clinical Virology Symposiu...
Dec 02, 2015•1 hr 1 min
Vincent visits the laboratories of Kit and Joseph Pogliano on the campus of the University of California, San Diego, where he learns about their work on the bacterial cytoskeleton, sporulation, and the effects of antibiotics on bacterial cells. Visit microbeworld.org/twim for complete shownotes including the special video version of this episode. Thanks for listening and watching!
Nov 20, 2015•56 min
Vincent, Elio, and Michele meet with Harry Mobley, Mary O’Riordan, and Vince Young at the University of Michigan, during the designation of the Department of Microbiology and Immunology as a Milestones in Microbiology site. They discuss how the laboratory has advanced the science and teaching of microbiology, and discuss faculty work on uropathogenic E. coli, induction of stress by bacterial infection, and the gut microbiome. Visit microbeworld.org/twim for more including the special video versi...
Nov 06, 2015•1 hr 11 min
Vincent meets up with Romney and Duncan at the 79th annual meeting of the Southern California branch of the American Society for Microbiology, where they talk about emerging technologies for antimicrobial susceptibility testing, and next generation sequencing and advanced molecular diagnostics. Visit microbeworld.org/twim to watch the video version and for complete shownotes including links mentioned.
Oct 22, 2015•54 min
The TWiM team wonders why definitions in biology often change, and discuss how the small molecule terrein is important for the growth of a soil fungus. Image: Lesion formation on banana surfaces infected with Aspergillus terreus. Source Links mentioned: ASM Undergraduate Research Capstone Program ASM Undergraduate Fellowship Program Regulation of terrein production in Aspergillus terreus Visit microbeworld.org/twim for more....
Sep 26, 2015•1 hr 1 min
Hosts: Vincent Racaniello , Michael Schmidt , and Elio Schaechter. The TWiMitos discuss the reconstruction of a 1,000-year-old antimicrobial remedy, and using gallium as an antimicrobial in the battle for iron. Subscribe to TWiM (free) on iTunes , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode 1,000 year old antimicrobial (mBio) Siderophore quenching with gallium (Evol Med Pub Health) Evolutionary dynamics of p...
Sep 10, 2015•59 min
The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile. Subscribe to TWiM (free) on iTunes , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Agar art contest Akkermansia muciniphilia and obesity (Gut) A. muciniphilia genome (Biol Direct) Alterations of gut microbiota and C. diffic...
Aug 19, 2015•1 hr 12 min
The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts. Links for this episode: Antimicrobial peptides to modulate microbial ecology (PNAS) Targeting specific bacteria in the oral microbiome (Trends Micro) How Wolbachia kills male hosts (PLoS Biol) Wolbachia phage on TWiV 332 Image: Transmission electron micrograph of Wolbachia within an insect cell. By: Scott O'Neill - ...
Aug 06, 2015•1 hr 9 min
Hosts: Vincent Racaniello , Michael Schmidt , Elio Schaechter and Michele Swanson . The professors of TWiM discuss a University of Wisconsin plan for rescuing biomedical research in the US, and results of a clinical trial in Bangladesh of an oral cholera vaccine. Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Rescuing biomedical research (eLife) Rethinking graduate and postdoc educati...
Jul 23, 2015•1 hr 12 min
Hosts: Vincent Racaniello and Michael Schmidt . Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron. Subscribe to TWiM (free) on iTunes , via RSS feed , by email or listen on your mobile device with the Microbeworld app . Links for this episode Microbiome of uncontacted Amerindians (Sci Adv) Urinary composition controls siderocalin activity (J Biol Chem) Urine acidity and UTI susceptibili...
Jul 09, 2015•1 hr 31 min
Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against Franciscella tularensis, the causative agent of tularemia.
Jun 24, 2015•1 hr 17 min
The TWiM team reviews the microbiological safety of herbs in the United Kingdom, and how a peptide from the milkweek bug binds the ribosome and inhibits bacterial protein synthesis. Links for this episode: Microbes in whole-leaf herbs (J Appl Micro) Antimicrobial peptide blocks ribosome (Nat Struct Mol Biol) Bacterial protein synthesis (Micro Mol Biol Rev) Antimicrobial peptides (Nature) The battle for tryptophan (Front Cell Infect Micro) Image credit...
Jun 05, 2015•58 min
Hosts: Vincent Racaniello , Michael Schmidt , Elio Schaechter and Michele Swanson . The TWiM team discusses how measles vaccination protects against other infectious diseases, and links between bacterial biofilms and colon cancer. Subscribe to TWiM (free) on iTunes , Stitcher , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Links for this episode Measles vaccination prevents all-cause infectious disease (Science) Master of contagion (The Loom) Video: Mea...
May 21, 2015•1 hr 4 min
