Here's How the New Weight Loss Drugs Could Change Everything - podcast episode cover

Here's How the New Weight Loss Drugs Could Change Everything

Aug 17, 202355 min
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Episode description

There's a new class of weight-loss drugs in town. GLP-1 medications including Ozempic, Wegovy and Mounjaro were created to treat diabetes but have since been found to suppress appetites and induce substantial weight loss. It's a big deal for the companies which make them, with shares of Novo Nordisk and Eli Lilly all soaring in recent weeks. But the drugs could end up having a much broader economic impact too. On this episode, we speak with James van Geelen of Citrinitas Capital, about the second-order effects of effective weight-loss drugs. He talks us through how he's evaluating the potential of the new meds and how he approaches possible 'mega-trends' like GLP-1 or AI.

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Transcript

Speaker 1

Hello, and welcome to another episode of the All Thoughts Podcast. I'm Tracy Alloway.

Speaker 2

And I'm Joe Wisenthal.

Speaker 1

Joe, would you ever go on ozembic?

Speaker 3

Oh?

Speaker 2

Yeah, definitely?

Speaker 3

Yeah?

Speaker 2

Really well yeah, well not. This seems fun.

Speaker 4

It reduces your appetite, probably lose weight. It seems like it also has a bunch of other I keep seeing these other things, like it's good for like, you know, impulse control and all kinds of positive things that, yeah, why not.

Speaker 1

Yeah, it's supposed to be good for impulses and addiction. And also I think there's some new stat out saying that it reduces the risk of heart attack and stroke by twenty percent. Well, anyway, who would you?

Speaker 3

I think?

Speaker 1

Yes, however, I would definitely wait for the price to come down a little bit and maybe for more of the side effects to become a parent, but I'm very cautious with these sorts of medical breakthroughs.

Speaker 5

Uh.

Speaker 2

Yeah, I have to. I feel like my like, I don't know that.

Speaker 4

Much about all these drugs like ozimpic and mcgovey and the other golp ones, but they seem pretty great, and I'm just like, yeah, upward and onward. The March of progress science. I love it, no, but I actually do think like it is. Something I've been thinking about is like people are so skeptical of even the possibility of the existence of a wonder drug.

Speaker 2

The people are like, Oh, it's.

Speaker 4

Going to do this, it's going to do this, it's going to be bad, it's going to reverse, it's going to and maybe that's possible.

Speaker 2

But what if it really is a wonder drug?

Speaker 1

Well exactly, And I think it opens up a ton of interesting questions, specifically about what it means for wider society and the wider economy. When we know that obesity and diseases like diabetes have been this huge weight on both the socio economy and the healthcare industry.

Speaker 4

Obesity itself is like just this gigantic economic force. It's a business force. There are businesses that thrive on how much people like to eat unhealthy foods.

Speaker 2

They're huge costs to ensures.

Speaker 4

There are other second order effects of related to injuries and heart complications and so forth. It's such a modern important phenomenon that we're there to be and maybe it kind of looks like there is, but.

Speaker 2

We're there to be.

Speaker 4

This sort of like straightforward way to reduce obesity. It seems like the implications would be huge.

Speaker 1

Right, And I keep getting visions of like Star Trek in my head where everyone is kind of slim and dressed in tracks great and very athletically capable, and we all just wander around spaceships. So that sounds great.

Speaker 5

Well.

Speaker 1

Anyway, on a serious note, I think we need to dive into these new sets of drugs. What exactly are they, how do they work, and more importantly, more interestingly, what do they actually mean for the wider economy and the business environment.

Speaker 4

So many I'm so glad we're doing it because it does feel like beyond just the companies selling these drugs, which we know have been taken off. We're recording this on August ninth. Just yesterday Nova and Nordis, the Danish company, soared because they had another test showing that one of these drugs was very good for fighting heart disease. So we know that there's like the interest in the vendors

the sellers of these drugs. But again, what does it mean all these second and third order effects if they really become extremely widespread and it kind of looks like they're on the trajectory feels very unexplored.

Speaker 1

Yep, So let's dive into those second order effects of miracle weight loss drugs. A fun episode ahead. We have really the perfect guest. We're going to be speaking with James Van Galen of Citrinidus Capital also known as Citrini on Twitter. So, James, thank you so much for coming on.

Speaker 5

All thoughts, Hi, Tracy, Joe, thanks for having me.

Speaker 1

So, James, from what I remember, you actually have something of a medical background. Is that right?

Speaker 5

Yeah? I worked my way through undergrad as a paramedic for a while in Bridgeport, Connecticut, and then when I transferred to UCLA, I worked as a paramedic in Compton, California. So I'm not a stranger to the medical field. Then for about four years I started what co founded one of Connecticut's first medical marijuana dispensaries. So I definitely am not a stranger to the medical field. Now I do the hedge fun thing, and it comes in andy once in a while.

Speaker 4

Investing in medical technology or sorry, you know, I or biotech. Often it seems like the sort of like Roulette wheel, And I'm always skeptical that anyone who is like not a scientist can actually have informed insights on new medicines and how big they could get, et cetera. Can you just sort of like give your overview of like how do you even like think about these things? Like if you're not like a scientist, how do you even begin to wrap your head around like how do these drugs work?

And how big they could be? And which ones I have more potential than others? Like what's your like framework for like sort of just like evaluating some breakthrough in the first place.

Speaker 5

I mean, I don't do a ton of like biopharma investing. I'm not a scientist, but I do have a bus network of channel checks and I'm a big proponent of basically if you don't know something, ask you know, and we are so so I am. You know, I'm always bothering them, and you know I'll cost me as a couple of dinners or something. And but you know, I don't do much, if any investing in companies that are still clinical stage, right, And you know, a lot of

my investing is kind of thematic investing. It's focused on these kind of paradigm shifts, these mega trends essentially, and when you see something like this, right, you know, all the feedback from channel checks is good, and it's something that we kind of needed as a you know, as a in developed markets at least for decades, right, And you just see the kind of behavioral incentives that exist

surrounding it. And I always come back to basically you look at like viagra in the nineties, and you know, you did not have to be a doctor to kind of see Pfiser just killing it, you know, just doing amazingly with this drug that solved the problem that people had that you know, needed to be fixed and it worked. And you know, honestly, that might be the reason that

most of us know who Phiser is, right. So you know, whether it's buying Maderna when they're developing a co vaccine, or buying Eli Lilly when they're developing, you know, a fat vaccine, or a Pfiser with Bager in the nineties, it all falls under the mega trend looking for kind of these paradigm thematic shifts.

Speaker 1

I think people forget nowadays that viagra was initially developed for something totally different to what it's used, and that happened to be a sort of happy side effect of the medication. I guess and then it became known for that. But just on this note, let me ask the basic question, So how did these drugs gop one I'm not even sure what that stands for, but how did these come

into being? And how are they starting to spread through the market such that I meet vcs who will openly say that they're on a zempic and I'm pretty sure they don't actually have diabetes.

Speaker 5

You know. So GOLP one stands for glucagon like peptide, not to get I don't want to get like two scientific but basically, the peptide helps kind of prime insulin release, right. It allows the body to absorb glucose after a meal, and you have specific cells in your pancreas that can recognize GLP one through what molecules called receptors. Right. So essentially we've been looking into these drugs you know, called peptider. The medical field has been looking into them, you know,

since the seventies. And GLP one's primary benefit was the fact that it was able to produce blood glucose levels via insulin release, which is you know, very desirable in a patient with diabetes. And the thing was the you know, when it comes to peptides. Normally, you're trying to mimic the peptide that your own body produces. So the actual molecule glucagon like peptide one is only to able to

create these effects for a very short time span. And so what these genius anders discovered was that they can essentially mimic these hormones and have these molecules that bind to the receptors they're called agonists, right, and that can create an effect that lasts, you know, four hours or even weeks. And that was basically the basis of the initial development and the impetus for it was essentially to

go after diabetes. Right. If you have something that can regulate glucose that is possibly dysregulated in a patient with diabetes, that's kind of something that seems desirable, right. So they were kind of predicted to also prolong this feeling of you know, fullness and slow gastric emptying. And they also provide a variety effects in the brain. And these drugs do cross the blood brain barrier. And the first GLP one drug that was approved by the FDA was Exenotide.

It was marketed under the name Bieta. So Bieta was approved in two thousand and five, right, and primarily be used in type two diabetes. And while you have something like semic glutide right now, which is ozembic generic name frozenpic, and then Munjaro, which is Lily's drug. Ters Appetite is the generic fan. And the thing is once you have a class of drugs, but you can kind of anticipate

what the side effect profile will be. It's not necessarily that you can, you know, anticipate every single side effect, but you kind of you get an idea of the structural activity relationship. You get an idea of, you know, this dose dependent curve and where side effects start becoming apparent. And so with GLP ones they have side effects, right, they have some gi side effects, and these GLP one receptor agonists, like semic glutide, they can be pretty bad.

But what Lily saw was essentially it was decided that they would try it to go after different receptors in the same system, right, so they kind of get this. It's got like Ter's Appetite. Munjaro is basically a a

dual GLP one receptor and then GIP receptor agonists. So the way that that works is the GIP activity allows you to take a higher dose before experiencing the side effects, the GI side effects, and we also kind of know you know these since these drugs, you know, Trulicity was a big one that it was approven I think twenty fourteen for type two diabetes. It saw very wide use. So when you encounter someone and they're like, oh, you know, no, for sure, these drugs are going to aunt your insides,

you know, like I don't. I don't blame them for that because if you look at the history of weight loss medication, you think Fenn Fenn, right, which like basically melted your heart. Then you know vermon event, which was like this genius invention where the scientists were like, well, you know the cannabinoid receptors basically the receptors that THHC act on, those make you hungry, So if we block those receptors, then it should make you not hungry. And

it did. But you know what else the cannabinoid receptors make you is happy. So I don't know how they didn't see it as coming, but it made people very sad and increase the likelihood that they would commit suicide. And that so that drug was pulled very quickly, and you know, you kind of look at the pass of

the weight loss industry. People take you know, tapeworm pills and just doing absolutely insane things, and it's kind of like, Okay, now you have this drug and the absolute worst concern, you know that there's a warning on the FDA label is that it may you know, it may result in thyroid cancer. But the thing is the only time that that's ever been observed with these gop one drugs is

in mice. And the thing about mice is when you're doing a trial with a mouse, the mouse is not going to tell you I can't handle these side effects anymore, I'm going to stop taking the injection. Right, No mice drop out of trial studies. So what happens is, you know, like the if you were to take the equivalent dose that caused you know, these endoprin cancers in mice, before you reach that point, you would be so sick to

the level of not being able to function. And it is so the dose was much much higher, and that, you know, the it has not been observed in humans. And the other thing is this is probably a little controversial, but the fact is, like obesity is devastating, right, it is absolutely terrible the way that increases mortality. I mean, I'm going to drop some statistics that Lily dropped on an earnings call, which is that you know, there are

two hundred and thirty six OBC related health conditions. Type two diabetes risk is increased by two hundred and forty three percent in people with obesity, heart disease by sixty nine percent, high blood pressure by one hundred and thirteen percent,

high cholesterol by seventy four percent. And the contribution to all course call all cause mortality is so significant that essentially, if I had a drug that would again this has never been observed in humans, It's probably not going to be because of the relationship that I described with the dose. But let's say I had a drug that one hundred percent, no matter what, forty years you're going to develop that

word cancer from me. Even if that was the case, if it also one hundred percent of the time made you not opdes anymore, the net effect on your life expectancy would still be positive.

Speaker 4

You know, you mentioned in the beginning that you as an investor, you like to think about people called paradigm shifts or mega trends and so forth, and one of the things that thinking about it in this context, and I think there is a very good argument. I'm basically sold that the rise of these drugs will constitute a paradigm shift or a mega trend or something like that,

and I feel like many people buy that. But the other thing is that like betting on mega trend often is not trivial in terms of even if you could predict the trend, you might not know what to invest in. And so, you know, a good example might be say like the rise of Chinese industry or something like that over in the you know, in the twenty first century,

since it's entry into the WTO. And it's not like I don't think like buying like Chinese stocks have like been like some like extraordinary winner certainly like long stretches of time where that doesn't work. So like, what's the next step from identifying mega trend to then thinking about, okay, these will be actual winners as public market investments.

Speaker 5

Well, let me talk a little bit about hype, right, You just had Dan Lobe and talking about how it's more important to monitor you know, Reddit boards than it is to monitor fund.

Speaker 4

Baby Tracy's Tracy's message in her bloombergs.

Speaker 5

Tracy's ready to ready to spend up a fun that takes advantage of that. I think she's very proud of the redd investors. What was that the guy in the basement has the edge If that's the case.

Speaker 1

Yeah, well it's all about the story, all about the narrative, right, and the guy reading Reddit might have a better handle on that.

Speaker 5

But go ahead, right, this kind of you know, the metic investing. So yeah, you guys, ever heard of the Gardner hype cycle? Yeah? For those who haven't, the way that it looks is you have this kind of parabolic rise between the technology trigger and then the peak of inflated expectations, and kind of the axiomatic way to give an example of this would be the dot com bubble. Right.

You have the technology trigger, which is the Internet, and then you it kind of goes parabolic all the way up to the peak of inflated expectations, which would probably be you know, in nineteen ninety nine pets dot com type stuff where the things that are happening are absolutely ridiculous, right, the forecasts are insane. And the thing about a mega trend or you know, a theme that is persistent, is it doesn't go unnoticed for very long. It can be

a significant amount of time. But you know, you speak about like Chinese industry in the twenty first century, you know, like there was a period of time where you could have been early on that and you could have invested and made excellent returns that you know, the peak of inflated expectations, and then uh kind of exited before I guess I think maybe there was kind of a byphasics, so maybe it would have been the Asian currency crisis. But the then what happens is you get this trophic

disillusionment right where it's like this technology isn't real. Everything is kind of hyped up. It was all bs whatever. Right, it's a bubble, and that's exactly it was a bubble. And then you get this well, you know, the thing funny thing is people say it's a bubble while it's going up, which is kind of like when people say, you know, like, okay.

Speaker 4

This is the difference between a journal instor just a bu blah blah blah blah, and then other people are.

Speaker 2

Making a for chane.

Speaker 4

It's like right, like you know, like this is why no reporter should ever should ever get into trading.

Speaker 5

I mean, you know, like how long was you know, Bitcoin had a you know, awful year last year, but like how long was it going up for before? You know, like obviously it was a bubble. But like, you know, that doesn't mean that you have to like be like a monk about it. You don't have to have this monastic view where God forbid I benefit from a bubble. You know, those people are wrong. Who cares? So anyway,

you get to kind of this trave disillusionment. And then the next phase is kind of the slope of enlightenment where you know, you borrow a phrase from the VCS, it gets democratized. You know, you can go out in the street right now. If I got on the street and I ask someone what the Internet is, they're going to look at me like I have five heads. They don't necessarily have to know how it works, but they know what it is, right, And then you get the

plateau of productivity. In the prototypical Gardner hype cycle, the plateau of productivity is actually below the peak of inflated expectations. But I think most of the time in markets it's actually higher. Obviously, there's a bit survivorship bias on this. You know, nobody that owned pets dot Com benefited from

the plateau of productivity. But if you think about you know, Facebook, Amazon, Apple, you know these you know they or even you know, you look at like the nifty to fifty in the seventies, right, like some of them have had very bad returns, like IBM. But then you know, honeywell or carry your global you know,

you get the uptake on the GDP effect. And essentially this is kind of the enemy of the mega trend, right because it's very easy to recognize it in the beginning, and then if you're too late with it, you're gonna think that the peak of inflated expectations is just the

pullback right when it's not. You know, So this is kind of something where it's good to continuously monitor whether your thesis is playing out, whether it is actually had you know, whether it's artificial intelligence or you know, like you said, the rise of Chinese industry, or the Inflation Reduction Act and the impact and impetus of fiscal spending or you know, GLP one drugs that as long as you are on top of it and you can see, you know, what are the earnings expectations like and what

are the actually you know, like like Nvidia is probably gonna you know, beaten raised for the next couple of years, but then you you know, where is going to be the point where the expectations aren't sustainable and when it comes to you know, you said you wanted to talk about the knock on effects, which kind of I mean, that's my favorite part of these things, right, like like when you actually capture a theme and you know, let me ask you a question like do you think the

knock on effects are happening yet?

Speaker 1

I don't know what the take up. So my impression is that actually we should ask how much do these drugs actually cost because my impression is that they're pretty expensive and so they're not making huge inroads into the general population just yet, but that could easily change.

Speaker 5

Well, you know, right now, as far as weight loss is concerned. As an FDA on label indication, Novo has monopoly, right.

Novo has wegov, which is the drug that you know just was had the big headline about twenty percent production in heart attack risk and essentially when they had you know, they can much charge what they want, right, and the way that it's going to develop is Lily's drugman jar which is much more effective, and there are other drug bredits true Tide which is still in clinical trials, but Munjara will be approved for weight loss. But at the end of this year, you know that was reaffirmed by

or within the next six months. Right, that was reaffirmed by the Lee on their earnings call. And let me get the answer to the question first, because I want to go into something that's going to answer your question, but I do want to assess, right, so you think that the not going effects are happening yet no?

Speaker 4

So actually I've been wondering about this because I actually was kind of under the impression link. When are we going to see a company crash on earnings because they say, you know what, we're seeing our sales collapse because.

Speaker 1

No one's eating our chips.

Speaker 4

Has it come up on any like fast food calls?

Speaker 2

Yet?

Speaker 4

Has it come up on any like CpG company earnings calls yet? Like I remember, like last quarter, like check the textbook company said like, all right, we're running into trouble because AI is like affecting our ability to sell this product that helps people with their homework.

Speaker 5

So have we seen someone will ever say that again. You know that, right, Joe. Yeah, Now, even if it's happening, no one will ever blame AI again, right, they know what happened to Shtags.

Speaker 4

So is there are the companies yet that are saying, you know what, in our customer base, we're seeing a change in consumption patterns of something because of these drugs A ton really a ton?

Speaker 5

Yeah? So just to go through a couple, right, and this will answer your question Tracy right where First up, Yes, the drugs are expensive. These drugs cost about eight hundred to twelve hundred dollars a month, you know which is a lot, and that is for ozembic gob And like I said, you know, you don't have anything that makes

this much money that doesn't have competition. Right, So, yes, Lily will get approved for Munjaro on weight loss and then there will be a duopoly and that'll probably last, I don't know, you know, anywhere from a year to three years or something like that. But to come back to Viagra, right, if you think about it, Viagra in nineteen ninety eight cost eighty eight dollars a pill. Okay,

now it costs two. There there is whether it's through generics, whether it's through competition, you know, the cialis what the way that it works is, you know, you have you have competition, you have economies of scale, you have insurance coverage, you have you know, the generic drugs. Eventually, glp ones, in fact, in twenty thirty one will face mandatory discounting under the Inflation Production Act. So are they expensive right now? Yeah?

But and to come back to what we were saying before that still did not you know, GLP ones were mentioned a thousand times in the in the in the Q two Q three earnings. Wow, that's interesting. Only half of that was by pharmaceutical companies.

Speaker 1

Okay, I just I just did a transcript search and there's a there's a Herbal Life earnings transcript where they talk about GLP one drugs, like possibly back in the business.

Speaker 5

I will never short Herbal Life just because we also what happened with that. I am always willing to learn from another person's mistake. And you know, like, but of luck to actman if he wants to go after it again. But you know, if you have documents searched up, Tracy, you can look at metafest yeah, and metafest Yeah, Metafest. They heerbal life didn't get hit as bad. But you know, I don't know if that's I don't know what that was a function of. I think they tried to explain it.

I didn't really vibe with the explanation, but Metafest basically said that, you know, we're we sell things that you know, people use to lose weight, and there's like we cannot handle the competition from a drug that actually works, right that they you know, I think the direct quote is that, you know, customer acquisition is being pressured by GLP ones.

But you know what they're doing now. Their strategy is essentially okay, let's do it too, you know, yeah, everyone else's maybe right, just do something similar, yeah, exactly, and that you know, like I love a company that is like torqued up levered melting price like a melting ice cube, and then position and right in the center of like a you know, like a burgeoning you know, huge trend, right because you know, like a good example from another trend,

artificial intelligence would be like applied opt to electronics, right, which is like like it was destroyed and then you know, with eight hundred G and the data center demand for optical you know, it's a we're so back right, It was so.

Speaker 4

But I hadn't heard of Metafest, but I'm reading their descriptions and among the things that they and among the things that they make are pretzels, puff cereal, crunch drinks, hearty choices, oatmeal, pancakes, pudding. So I'm basically I don't know that maybe the products are delicious, but I'm imagining the type of things that people who are sort of like really trying to lose weight are, Like, I'm going to eat these puffs and shakes because they're a little bit healthier than the alternative.

Speaker 5

I mean, you don't need to That's the thing you don't need to work like, like, you know, I was talking about my channel checks earlier, and I have an end of chronologist, you know, like Eli Lily was one of my biggest positions from you know, twenty twenty two, twenty twenty one even, and it kind of got surpassed during the AI stuff. But I built up a basically, you know, like I would go to like an end up.

Whenever you have a position that's super big, you know you're on top of it, right, and you can expense a trip to enoprenologist conference and you go there and like I'm speaking to these people and they're like, I have a patient who was eating five thousand calories a day, which is like a full time job, right, like like

five thousand. Once you get to like five thousand and six thousand calories, that's like I mean that that is like eight full meals a day, right, And he's like, I am, he's having issues because I have to recommend protein supplementation because he can't get above five hundred calories a day. So if you look at a company like Metafest, that's basically you know, selling this food that's a little bit healthier for you and you know, maybe taste the same so that you know you don't have to you're

kind of getting better macronutrients or something. I mean, there might be an opportunity there for the protein shakes, but overall, like you don't really need to worry about if you're taking this struggle, you don't really need to worry about, uh oh, you know, let me buy food that's like more that's less calorically dense, because like it doesn't matter,

you're not going to eat it anyway. And this is kind of interesting because when you're looking at when you're like monitoring social media, you know, like always monitoring, like you know, Google trends, Wikipedia trends, and for a little bit, I think this was like the middle of last year, you know, monitoring Google trends, and this Google trend comes up called ozempic face.

Speaker 1

Oh yeah, people get really gone from weight loss.

Speaker 5

Literally like I had, and I'm like my fingers on the sell button. I'm like if it affects your face, like I'm out, you know, And it turns out like people were like, oh god, like ozempic causes you to have like, you know, like a gaunt face or something, and it's like not really, what's causing you to look gaune is the fact that you're losing a ton of

weight very quickly. Right. And you have another one where like people are like worried about hair loss and you know that is it's a condition called intelligent effluvium, right, which is basically the same thing when you lose too much weight. You you know, your body is kind of

like burning nutrients for energy. You're at a caloric deficit and you lose cair it's totally reversible, and with like ozembic face, It's like you can't see wrinkles on like an inflated balloon, right like it that's just how it works. And it's kind of amazing to me because you have this kind of imphasis where people are like, oh, like this is that, this is the side like we gotcha, you know, like this is I knew there was going

to be a catch. And it's like people are so unaccustomed to the idea of there being a weight loss drug that works that they are confusing the side effects of the drug with the side effects of the effects of the drug, which is you know, success being successful weight loss just.

Speaker 2

For voice worth.

Speaker 4

I'm sorry, I keep going back this. I'm reading the metafest transcript from earlier in the week and one of the one of the questions is rbal life doesn't say anything.

Speaker 2

I'm paraphrasing.

Speaker 4

Well, one of the questions from the analysts is erbal life didn't say anything about GLP one drugs affecting their business?

Speaker 2

What about you? And they're like, well, we're not going to comment.

Speaker 4

On rbal life, but yeah, we're feeling it, so yeah, it actually it came up. They also cited higher customer acquisition costs. Again, they say, pressured by less prospects being identified by coaches, impacted by competition from GLP one drugs, inflationary pressure.

Speaker 2

So it's coming up.

Speaker 1

Wait, so can I ask you a basic question?

Speaker 5

Wait?

Speaker 1

Wait, just before we go further, can I ask a basic question, which is, like how many people are on these drugs right now?

Speaker 5

I mean, so I would rather not comment, right, I think that I would never be talking about something like this if I didn't think that it was early, right, and the so like you can look at penetration like type two diabetes, right, you know, talking about like penetration of a drug that's been approved for an indication for

a year. You know, it's like you're not really going to get an accurate picture, you know, majarro And also a drug where like there's only been one approved for you know, and then you get also the fact that like there are talking about, you know, mentions on earnings.

There are significant supply chain issues with these drugs right now, like like Novo's having trouble sourcing the drugs coming in autoinjector right, which is basically if you think of an EpiPen, you know, you take it once a week and you know it's like a button that you wish but you look at like like talking still about like the earnings mentions, if you look at Stevenado or Garretsheimer or even Beckton Dickinson.

The problem is that they can't produce enough of it, which would tell you something about demand, right, like, like even I.

Speaker 1

Know this would turn into a supply chain episode eventually.

Speaker 5

Please don't try to get me to talk about the sly chainer so I will seem very silly. But the thing is just even Lily, right, Obviously they have to temper their optimism, but they're having to ramp up production at all, you know, five global facilities just because of the fact that like they're like overwhelmed. They could not

even have anticipated this level of demand. Right during Lily's earnings call, Chris Shibatani and analyst was asking a question that was basically like Novo and Lily, you've been confronted by this demand that was like beyond what you could have possibly planned for. And with Lily, you know, Majar isn't even a proof for weight loss yet, and so essentially it would be kind of premature to say, you know what the penetration of these drugs is right now.

But what I will say is that and I have a chart that I can you know, send you maybe can put it up on the site that essentially the obesity rate in the US in nineteen seventy four was twelve percent, right, and now it's forty two percent. And for the past five decades, there have not been two sequential years in which the obescd rate has ticked down.

It hasn't happened for fifty years. So you know, when you look at that, I first off, I think it's not just reasonable but rational to think that you can't have a society that has both advanced medication and then half of its populace affected by a disease and not think that eventually those two things were resolve each other. Right.

And if you look at the sixty eight week trial data Munjarro, and you adjust for you know, the average compliance, and you know which patients dropped out prematurely, and then you adjust for the fact that about after you drop out of the trial, about half of the weight loss you still maintained about half of the weight that you lost, but about half of it goes away, and so you adjust for all those things. If Munjaro a sixty eight week trial data has a thirty percent penetration rate in

the obese population. Right, the obeset rate in the United States would be lower than it was in nineteen ninety seven. And you know, like that could happen over the course of two or three years. And so for a line that has gone up into the right to go down, you know that significantly.

Speaker 4

So I'm not surprised that, you know, mentions of GOLP onees are popping up on various conference calls. You know, some obvious ways, like the company that maybe makes the devices for its use, or the companies that have some other weight loss solution that may be feeling pressure. But like for example, today again August ninth, we got earnings from Wendy's. No mention of GLP one there. Yet I

looked last month, we got earnings from PEPSI. And you know, if I were to think about, like, okay, in theory, in some future world where these drugs are very cheap and widespread, and who would theoretically be losers from drugs that reduce one's appetite for fast food, for salty foods, for high carb foods, whatever it is in your mind, is it obvious that A some of these big consumer oriented companies are going to be losers, and B if it is, when would you expect to see, like what

pick a predicted quarter when maybe this would.

Speaker 2

Come up on a Wendy's earnings call.

Speaker 5

Well, so let's think, you know, first off.

Speaker 4

Or or if the premise of the question is totally off the mark, that's fine too.

Speaker 5

No, no, no, I mean it's a it's a I don't know, we're talking about second order effects that this seems a little first order Joe, Okay, you're right, you're right. No, but no, no, I mean it's a great point, right, And I think that the sent I mean, you know, Wendy's sells so much food right like it's it's uh me too. I don't want to I don't want to

malign Wendy's. But the thing is, I think that if you wanted to be able to predict this, what you would have to do is you'd probably have to use all data or you know, credit card data, and you would have to look at the company and maybe eat a lot of fast foods for a month to figure out. But like, which of these companies you're going to be

my new analyst. No, which of these companies are willing to or are basically making up for or low margins with high volumes, right because the because it's not like these drugs are going to automatically make you, you know the Jack Lalane right, Like, you're not gonna You're not just gonna be like the hell you all your habits are healthy now, Like if you're eating fast food every day, you will probably continue to eat fast food every day. You will just eat a lot less of it, like

a lot less of it. And let's say chapatte for example, Yeah, probably not going to be that negatively affected, you know, like like people you know, they'll probably have the same order and they'll just finish, you know, a couple of bites bit or something. I don't necessarily want to speak to this, but just thinking of like RBI's for example, I think it's owned by a private company, so I

can you know, talk about without issue. But like the prototypical let's just speak theoretically, there's you know, all you can eat Biffet or something. They might do really well because people eat less, but at the same time they might be patronized less because you know, nobody wants all you can eat, and you're not getting a good deal anymore.

So if you have a company and you look at the data and basically the way that they make money is by selling a ton of food that they get very cheaply and make up for you know, kind of lower margins by selling a ton of it, that company probably isn't going to do too great. But you know, it wasn't just metafest for example, you know, going beyond the idea of like food being impacted, Like right now,

Lily has a trial for Munjaro. Basically, what these companies are doing is they are on this kind of blitz scale for like the data, right because like most of these things you can kind of rationally expect, like for example, with the Wigobi headline, Gooby reduces heart attack risk by twenty percent. I mean kind of like duh, you know, like like oh, like you know, if you if you go from being obese to not obese, you're going to

have a lower chance of heart attack. Right. But they but what they have to do is you know, have these you know, vigorous trials that actually prove it. Like so for example, Lily is going right now for obese induced sleep ABNA or ni osio or arthritis, and so like a company like res Med. Right, ResMed was talking about it for you know, like a while on their earnings call, and the response was essentially, you know, I'm trying to remember exactly what they said, Oh right, a

seatbad machine. The costs over a lifetime for a seatbad machine are like about fifteen thousand dollars. And then they did their own math, which was like, well, these GLP one drugs cost one thousand dollars a month, and if you multiply, if you have a forty year old patient, you multiply that by forty years, Well, really a GLP one drugs, you know it's going to cost you four

hundred and eighty thousand dollars. So obviously you know we're coming in at fourteen fifteen thousand, where obviously the option we're not going to be really affected by this. And you know, to take that into consideration, you say, why

would people be taking this for forty years? Right? Like, why would if they if someone you know, seventy percent of sleep apne is caused by obesity, If you have someone that's taking it and they take it for let's say sixteen months and they go from being obese to having a normal body weight, and then in all likelihood at least for like seventy percent of them, the obstructive

sleep abne goes away. I mean you have to just kind of the total addressable market for a company like res med or for the c PAFT industry in general, it is going to shrink, right, It's kind of and even you know, and then when people say that you know this is a fad or you know this won't work again, you look at like like when was the last fad weight loss drug that had Intuitive Surgical talking

about on the earnings call? Right, Like Intuitive Surgical they're not ready to speak to it, but they mentioned it on the earnings call. And then you have another company. I think this was my favorite one, right, and it wasn't even because of anything the company did or said. It was just because I'm reading the prepared remarks and the exact text was basically, you know, the company is called Teleflex, and it essentially it's a company that makes

devices for sleeve. But sleeve gets direct to me like the bariatric surgery weight loss surgery. You get the sleeve and the thing is, you know, sleep gas tractomy. I think the average weight loss over seventy two weeks is like twenty six or twenty seven percent, And with Munjaro it's a little bit closer to depending on the dose, between like seventeen and nineteen percent. But Lily's new drug, the triple agonist red true Tide, is showing like twenty

four to twenty five percent. Right, So in the prepared remarks, they're basically saying, we did see an effect from GLP ones on the demand for bariatric surgery, which affected the demand for our device, the Titan stapler. Wait, so if I ask you, Tracy, if you want to lose weight, would you rather take or get Titan staples? Like? Like, like you want to go with the Titan stapler? I don't think so.

Speaker 1

Why didn't they call it like suft staple or a gentle staple? Titan is just a terrible name for any surgical procedure. Okay, Wait, So one of the reasons talking about this is fun is because it is kind of a giant thought experiment of what a world of fewer obese people would actually mean. How far can you take it? James, like to, what's your most interesting sort of second order trade idea based on a widely available weight loss drug.

Speaker 5

Well, I think that you know, if I'm going to stretch this as you know, as far as it can go, the first thing is stretching it as far as it can go gets pretty stretched because I mean, the direct medical costs this year from obessie, they're going to be three hundred and seventy billion dollars. The indirect costs are

going to be over a trillion. McKinsey in twenty twelve, when the OBCD rate was like I want to say, seven or eight percent lower, they estimated that OBESD results in an annual global an annual global economic impact that is equivalent to two point eight percent of the global GDP. So you think about like productivity six days, you know, workers comp injury, I mean life insurance, health insurance, workers

comp insurance. It something like that. When you have a when you have a literal disease state that is affecting forty two percent of your population, it's kind of hard not to stretch this far, you know, like like if that gets fixed. But in terms of the one that I would share on a podcast to be entertaining, I would say, like match group or bumble as along. If you look into like just general, everyone feels.

Speaker 4

Themselves and so they get to advertise them that's in a product in the dating marketplace.

Speaker 5

And you know what's interesting about this, you know, match group. I already think that the fundamentals look good here, but you know, if we're going to like stretch it super far, you look at like match groups last earnings and like payers were flat or decreased a little bit for tender,

but they increase significantly for hinge. And if you look at like there are like, you know, social sciences studies about like the effects of obesity on like your how happy you are and how satisfied you are with your dating life and stuff, And I think, I don't want to butcher the results or something, but it was basically across genders, right, like if you are female or male, the effect of losing ten or twenty pounds on your average you know, satisfaction with your dating life and with

just generally how happy you are. It's a lot more significant in females. So you know, maybe if you want to like be super early and stretch it super far. Maybe the reason that like hinge is getting more popular than tendered. Maybe it's because it's easier to lose weight. I don't I would not say that in like an authoritative way, but you know, I just say, yeah, that's

that's the thing. I'm going to get quoted a like, No, this is a crazy guy thinks that, like match group is going to moon because of you know, No, I guess I just say I get, I get how the internet works, though this is I know, I know it's funny.

Speaker 4

I keep reading through conference calls after you mentioned them. I'm looking at the res mid one and did you look at Titan State, But they're talking about They're like, well, they're like because clearly this is a source of anxiety for them. So they're like, oh, well, like uptake and

like endherance is not really that good. And then a very funny thing they say, because Biden had that mark on his face is our biggest side effect is President Biden had a little mark on his face and he was asked about it and it was from his CEPAP.

Speaker 5

Look.

Speaker 4

I think it's a good long road to play out here. I think it's frankly good marketing. So President Biden, because he had to put a device on his face for his sleep problems.

Speaker 5

The company is setting it market, did we just I mean, I saw I saw a photo of Justin Trudeau at Imax, so maybe I should get long Imax.

Speaker 4

You know, it seems like a big deal, like just zooming out. It seems like a big deal. Even if we like set aside what it's going to do to PEPSI or what it's going to do to like freedom lay or that's the same, you know, what it's going to do to all these consumer companies, you know, health insurance.

You mentioned that like obesity plus obesity related diseases are huge, and so if they were to go down and you see maybe you see some of that in the sort of weak stock price of res med anxiety about this?

What does it mean just like for like health insurers and also just like healthcare utilization in general, Like you know, generally we think of like healthcare as like a line that only goes up that if you're a healthcare professional, you're like gonna do very probably likely very well guaranteed demand. What is the effect on just sort of like the broader healthcare institutional healthcare industry.

Speaker 5

Since you've already got documents search slouded up, why don't you check out Insparity. The ticker is a NSP.

Speaker 2

This is a fun guy.

Speaker 4

I was like just hearing different names and then I look at looked them up during the answer.

Speaker 2

But yeah, keep going.

Speaker 5

Welcome to my life during earning season. Document search is my favorite feature. But you know, if you look at Inspirity, you can kind of see. I don't want to misquote anyone, so I'll just put it up very quickly.

Speaker 3

Look at the share price.

Speaker 4

Hey, this is the company offers recruiting, employment screen and retirement business insurance.

Speaker 2

Yeah, what is this company?

Speaker 1

It's down about sixteen percent.

Speaker 2

That's what matters. I can't figure out what they do and what their connection is here.

Speaker 5

So we're going to.

Speaker 1

Find out human resources and business optimizations.

Speaker 2

No, no, no, yeah, but I don't so what's the here.

Speaker 5

So here's the deal, right. They also offer you know, employed benefit administration, which you know, like like health and so if you want to boil it down to two things, like, Insparity got hit on the fact that like people want these drugs because they don't want to be fat and the drugs make them not fat, and Insparity apparently thinks that you know, that is a fad. They were saying something that was like, oh, you know, the effects are

going to wane because of the side effects. And when you think about it, like these drugs were originally developed for type two diabetes, and it's like, oh, you know, there's never been a drug before that was developed for one thing and then ended up being really good for the other, you know, just like Tracy said with Viagra.

And basically they said, you know, large claim activity accounted for approximately seventy five percent of the higher costs with claims over seven hundred and fifty thousand dollars, and the remaining twenty five percent is related to higher than expected pharmacy costs. As for higher pharmacy costs, we experienced an in increase and utilization of the specialty drugs, including a significant step up in the use of diabetes and weight

loss drugs. And then they talk about behavioral health drugs to behavioral health drugs too, which is probably you know, I mean, I don't know, that's a whole different conversation with COVID and behavioral health drugs. And you know, like how people have emotionally reacted to the last three years. But when you look at it, for insparity. It's probably bad right now because you know, as long as these companies have a duopoly on these drugs, the cost will

probably be hot. But that can only last for so long. You know that eventually there will be competition. Eventually the cost will go down. Eventually it'll be like Biagra, where it goes from you know, eighty eight dollars pill to whatever two dollars a pill. Maybe it was bad quarter for insparity. Maybe that continues for a little bit while

they're still expensive, and then eventually it'll get better. But when you think of it from let's say Signa or United Healthcare Signa on their earnings called they said, you know, GLP ones are definitely top of mind for many of our clients. There's been a meaningful upticking utils station. And essentially what they said was, you know, there's a continued

interest in behavioral solutions. You know, these insurance companies they will like pay for you to get a gym membership, or they'll pay for you to get a meal plan or something, and the success rates of those things are dismal, like absolutely awful, right and you know it doesn't work. And insurance companies are stakeholders in global health, right, and they're really good and anticipating how much it's going to cost and making sure, you know that they make more

money than what it's going to cost. But as an epidemic, this is still like a relatively new thing. The obesity rate has never been forty two percent before, and so what do how can we really accurately model what that's going to look like in fifty years? I mean, you know, maybe if it continues the way that it's going unobated, I think that ultimately, you know, health insurance that it's

going to be a significant hit. So what you're seeing is these drug drug companies essentially going on these data campaigns, which is, you know, we're going to show you not just that it results in weight loss. We're going to do a study and a clinical trial on every single one of the beneficial effects of losing weight. Right, We're going to say, oh, obstructive sleep, at hyper lipidemia, hypertension, heart disease, type two diabetes, knee replacements, all of this stuff.

And then eventually it is for Signa or for United Healthcare, it is going to be They're they're going to do what insurance companies do. They're going to negotiate. They're going to push down the price. They're gonna you know, they're gonna there's going to be pushback. There's going to be what cut gets covered and what doesn't, especially after Munjara

gets approved for OBCD. But at the end of the day, the thing is they are basically going to have to do a cost benefit analysis, and there is no way in my mind, I think really even if they were paying one hundred and fifty percent of what Lily's charging and didn't negotiate at all, over the course of the next twenty or thirty years, they would probably make money. Like they would probably be a better situation than it would be without it, you know, not to get too

like insanely off the rails. But again, it's a podcast, so.

Speaker 1

This thing is experiment, So let's do it.

Speaker 5

Let's entertain some people. Right, why shouldn't the government pay for this?

Speaker 4

Well, you mentioned that the Inflation Reduction Act is going to reduce the cost. This should be Biden's re election. He's like, hey, I signed the bill that's given.

Speaker 5

Yeah, let's look, let's look at this. Right. We just had like the biggest public health experiment ever. You know, we had COVID. Right, Like, how many does anyone know off the top of their head how many people COVID? I don't, that's not a fact that I have handy, but right, but and how many people? What was the all cause mortality of like COVID in like annually during like the peak of the epidemic. It was probably high.

But what I'll tell you is it probably was similar to how many people are going to dive over city this year. You know, I don't want to like speak without facts in front of me, but I would say, you know, if if someone wants to go look that up and you know, whether it's how many people divebcity this year or how many and five years, I would say that they are probably comparable public health crises. And

also in terms of the impact on the economy. Obviously, nothing can rival shutting down the entire economy and you know,

having a lockdown. But if you look at it from a cube versus chronic perspective, you know, if obesity is going to cost us a trillion dollars this year in indirect costs, and we're running it a trillion dollars a year, I mean over the next ten years, like what it just seems like something where it let's say that you know, Lily and Novo and all the other companies that eventually join the FRAY that they're effective in proving that the

side effects are moderate and that the overall benefit is sustained, and it's good. Why would the government not cover it? Right? Like, if they're if they'll cover COVID vaccine, should probably cover this too, especially if it has a twenty percent production like heart attacks.

Speaker 1

I mean, well, I would never overestimate America's ability to make bad decisions when it comes to public health care.

Speaker 5

But that's a good point.

Speaker 1

But James, that was a really fun conversation. Absolutely a blast to have you on and go through the transcript sort of in real time while we're talking to you.

Speaker 3

That was great.

Speaker 5

Absolutely, And you know, if you want to learn more, you know, I've been writing about this since June on is suctriniresearch dot com. I go pretty deep into these I did want on a yeah, oh you you read it, Come on, we do a little.

Speaker 1

There's much believe it or not.

Speaker 2

There is something that I read it.

Speaker 4

On the subway this morning while coming in. I do real prep for this job.

Speaker 5

I send it to you like twelve hours beforehand, and I know it's like, you know, twenty pages long, so I would have forgived you.

Speaker 1

All right, well, James, thanks so much for coming on all thoughts. Appreciate it.

Speaker 5

Thank you so much for having me guys.

Speaker 2

Thanks James, that was a blast.

Speaker 1

All right, well, Joe, I for one look forward to the spelt future of publicly funded weight loss drugs.

Speaker 4

I mean, I totally like, why not if all the things seem to be true about this what many people seem to believe. And you know, it's like James is like totally right, Like you see a lot of people like poking there, like there must be some catch here, right, there must be just gonna melt your insides or it's gonna do something. Maybe one day, you never know, but right now, anything I read about the side effects never seemed like that compelling or anything.

Speaker 2

And he just point out the classic drugs for a while, it kind.

Speaker 4

Of feels like potentially like a legit miracle drug, right, Like it's kind of wild.

Speaker 1

Well, I think he makes an excellent point about the trade offs, right, and at some point it might be cheaper for an insurance company to just provide this drug rather than treat someone for diabetes or heart problems or sleep apnea or whatever else for the rest of their lives. The other thing I was thinking throughout all of that, you know, I initially came into the conversation thinking like, oh wow, if everyone's consuming less, yeah, maybe that's deflationary.

But now I'm going back to that price over volume oh theme. And James brought it up as well, which is, well, if you're Wendy's and people just aren't buying as many cheeseburgers, then maybe you just raise your prices to offset it.

Speaker 4

Could be the I am cures. I mean, there's all kinds of like other things that we could get into. Yeah, and so another thing, and I saw someone on Twitter say this, They're like, well, well, the snack companies put even more salt.

Speaker 2

And other addicting type of.

Speaker 4

Like ingredients to counter setting the people who aren't taking the drugs buy even more in the future, Like they're not going to give up without a fight if there's some drug that causes people, you know, like everyone's gonna like try to like find some way. We didn't talk about gyms really, but I wonder like, like one way of thinking is maybe it's bad for gyms. But on the other hand, like if maybe one to show off,

that's exactly right. If you feel more confident, then maybe, like you know what, I'm ready to I don't mind being seen at the gym. All kinds of interesting questions, Like I like the idea of like, you know, Madge or Hinge is a bye or is like a winner here? So that was a very fun thought insperiment, and it was fun in the context that he knew so many details, so it was like also kind of real nudges.

Speaker 1

Yeah, and I'm going to spend I think the next like two hours or so just going through some of the Earnings transcripts and saying what people are saying about this, because I hadn't realized that people were already actually talking about it.

Speaker 4

Well, so I think the reason I didn't realize it is because I was searching azimbic. It's just like the thing all searching. You just search GLP and then tons come up, and so it's really interesting. I mean, it's a huge focus on a lot of these calls just from looking it up.

Speaker 1

All right, well, fun conversation. Shall we leave it there, Let's leave it there? Okay, this has been another episode of the All Thoughts podcast. I'm Tracy Alloway. You can follow me on Twitter at Tracy Alloway.

Speaker 4

And I'm Jill Wisenthal. You can follow me on Twitter at The Stalwart. You can follow Hello James Van Galen on Twitter at sutrini seven. Also check out his research. Follow our producers Carmen Rodriguez at Carman Arman and dash O Bennett at dashbot and all of the Bloomberg podcasts can be found under the handle at podcasts. And for more odd Loots content, go to Bloomberg dot com slash odd Lots where we have a transcript.

Speaker 2

Blog in a newsletter and we don't have.

Speaker 4

A pharmaceutical channel and there maybe we've got to add a medicine and health one. But check out the discord, one of my favorite places to hang out on the internet. Other odd Lots listeners are there talking twenty four to seven, Discord dot g slash on.

Speaker 1

And if you enjoy odd Lots, if you like listening to these types of conversations imagining a world without obesity, then do leave us a positive review on your favorite podcast platform.

Speaker 3

Thanks for listening. In a

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