Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Christian Gaebler Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Evolution of antibody immunity to SARS-CoV-2 (Nature) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Medic...
Feb 13, 2021•1 hr 11 min•Ep. 42
Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Madina Wane Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Black in Immuno (YouTube) Cytokines and gill homeostasis (J Immune) Zebraf...
Jan 25, 2021•1 hr 23 min•Ep. 41
Immune reminisces about a year in COVID-19 immunology, Steph's receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Immune response during common cold CoV infection (Epidem Infect) Summar...
Dec 30, 2020•1 hr 35 min•Ep. 40
Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Reflections of a COVID-19 long hauler (JAMA) Not a cytokine storm in COVID-19 (...
Dec 01, 2020•1 hr 24 min•Ep. 39
Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Sallie Permar Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Immune correlates of...
Nov 28, 2020•1 hr 11 min•Ep. 38
Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guests: Alexis Mobley , Joel Babdor , Elaine Kouame , Justine Noel , Evonne Jean Become a patron of Immune! Links for this episode Black in Immuno Black in Immuno week sche...
Nov 16, 2020•2 hr 1 min•Ep. 37
Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Alexander Dent Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Loss of germinal centers in severe COVID-19 patients...
Oct 21, 2020•1 hr 28 min•Ep. 36
Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode COVID-19 severity linked to antibody levels (bioRxiv) Review of antibody mediated immunity to coronaviruses (Nat Com...
Sep 23, 2020•1 hr 20 min•Ep. 35
Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Cross-reactive coronavirus CD4+ T cells (Science) Immune misfiring in severe COVID-19 (Nature) A COVID-19 riddle for the immun...
Aug 25, 2020•1 hr 27 min•Ep. 34
Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode CD8 cells defend against SARS-CoV (J Virol) Deep immune profiling of COVID-19 patients (Science) Letters read on Immune 33 Image credit Time stamps by Jolene . Thank...
Jul 28, 2020•1 hr 24 min•Ep. 33
Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Keep CoV off campus (NY Times) Inflammatory cytokines predict COVID-19 death (medRxiv) Imbalance...
Jun 05, 2020•1 hr 31 min•Ep. 32
Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode How long will a vaccine really take? (NYTimes) Humoral immunity in NYC COVID-19 patients (medRxiv) D614G is ju...
May 08, 2020•1 hr 30 min•Ep. 31
Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode IL6 as COVID-19 marker for severity (Med Mal Infect) How does COVID-19 kill ? (Nature) SARS-CoV-2 protective immunity ...
Apr 17, 2020•1 hr 23 min•Ep. 30
Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode ACE2 in oral mucosa (I J Oral Sci) IL6 predictor of COVID-19 death (Int Care Med) Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv) An...
Mar 31, 2020•1 hr 27 min•Ep. 29
Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Irene Salinas Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Evolution of mucosal Ig in rainbow trout (Sci Immunol) Fish olfactory neurons mediate rapid immune response (PNAS) Image credit Time stamps by J...
Feb 08, 2020•57 min•Ep. 28
Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode H3K4me1 mark on memory-like NK cells (Cell Rep) Letters read on Immune 27 Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Medical . Send your immunology questions ...
Jan 11, 2020•1 hr 34 min•Ep. 27
Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Michael Mina Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Measles virus infection diminishes pre-existing antibodies (Science) Public epitope #1 ( TWiV 342 ) Incomplete reconstitution of B cell pools after...
Nov 28, 2019•1 hr 38 min•Ep. 26
The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode CD8+ T cell memory needs microbiome derived fatty acids (Immune) Image credit: Principles of Virology 4e Time stamps by Jolene . Thanks! Letters read on Immune 25 Week...
Nov 01, 2019•1 hr 22 min•Ep. 25
The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode New type of T helper cell drives anaphylaxis (Science) Image credit Time stamps by Jolene . Thanks! Letters read on Immune 24 Weekly Science Picks Cindy- Lasker Award 2019 Vincent- Eleanor's Breakthrough video...
Sep 19, 2019•1 hr 29 min•Ep. 24
The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Genetic variation in laboratory mice (Immunity) Time stamps by Jolene . Thanks! Vaccines and Your Child Letters read on Immune 23 Weekly Science Picks Steph- University of Alaska budget crisis Cindy- 90% survival fol...
Aug 14, 2019•1 hr 27 min•Ep. 23
Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Engineering B cells to produce antiviral antibodies (Sci Immun) Time stamps by Jolene . Thanks! Letters read on Immune 22 Weekly Science Picks Steph- Breath of fresh air Cindy- Biologist found dead Vincent- Nobel Prize...
Jul 31, 2019•1 hr 18 min•Ep. 22
Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time stamps by Jolene . Thanks! Weekly Science Picks Steph- Unique Scientists Cindy- Researcher app Vincent- STL...
Jun 12, 2019•1 hr 27 min•Ep. 21
The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis. Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Inflammasome activation triggers blood clotting (Immunity) Rotavirus and Nlrp9b inflammasome (Nature) Societal Amnesia and vaccines by Cindy Leifer Image credit Letters read on Immune 20 Time stamps by Jolene . Thanks! Weekly Sci...
May 29, 2019•1 hr 28 min•Ep. 20
The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease. Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Maternal immunization protects offspring (Sci Trans Med) Diversity of herpesvirus in neonates ( TWiV 540 ) Mariana Mazzucato on Freakonomics Letters read on Immune 19 Time stamps by Jolene . Thanks! Weekly Science Picks Steph- iNaturalist Cindy- Taking a break is also har...
Apr 17, 2019•1 hr 17 min•Ep. 19
The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Trogocytosis for T cell antigen discovery (Nat Methods) Trogocytosis (J Immunol) Orphan T cell receptors (Cell) Letters read on Immune 18 Time stamps by Jolene . Thanks! Weekly Science Picks Steph...
Mar 27, 2019•1 hr 21 min•Ep. 18
The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Darwin Day Metabolic rewiring of macrophages by CpG (Nat Immunol) Letters read on Immune 17 Time stamps by Jolene . Thanks! Weekly Science Picks Steph- Pregnant Scholar Cindy- Anti-vaxxers vaccinating against measles Vincent- Center for Science in the Public Interest Music by S...
Feb 13, 2019•1 hr 8 min•Ep. 17
The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Role of B cells in Marek's disease pathogenesis (PNAS) In ovo vaccination (YouTube) First chickens lacking B cells (PNAS...
Jan 19, 2019•1 hr 13 min•Ep. 16
Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Slings enable neutrophil rolling (Nature) Sling video (La Jolla Inst Allergy Immunol) Neutrophil extracellular traps kill bacteria (Science) Neutrophil revie...
Dec 22, 2018•1 hr 26 min•Ep. 15
The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode 2018 Nobel Prize in Medicine 2018 Nobel Prize in Medicine ( pdf ) What's in a name? (Can Res Inst) Checkpoint inhibitor failures (Nature) Image credit Time stamps by Jolene . Thanks! Weekly Science Picks S...
Nov 14, 2018•1 hr 20 min•Ep. 14
The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Host lncRNA binds RIG-I (Cell) Microbe Art at virology blog Letters read on Immune 13 Time stamps by Jolene . Thanks! Weekly Science Picks Steph- That's Pediat...
Oct 20, 2018•1 hr 17 min•Ep. 13
