The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Immune system development in newborns (Cell) Dead parrots and live wildcats ( TWiV 185 ) Pathogenesis card game (JAMA) Letters read on Immune 12 Weekly Science Picks Steph- Kaleidoscopean Cindy- 500 women scientists Vincent- NIH budget increase 2019 Music by Ste...
Sep 19, 2018•1 hr 12 min•Ep. 12
Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts: Vincent Racaniello and Cynthia Leifer Become a patron of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent- Unpaywall Music by Steve Neal . Immune logo image by Blausen Medical . Send your immunology questions ...
Aug 18, 2018•1 hr 9 min•Ep. 11
The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Rebecca Lynch Become a patron of Immune! Links for this episode Lynch Laboratory Immune merchandise Image credit Music by Steve Neal . Immune logo image by Blausen Medical . Send your immunology questions and comments to immune@microbe.tv...
Jul 21, 2018•1 hr 16 min•Ep. 10
The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Lamprey VLR response to influenza virus (eLife) VLR-based immunity (Ann Rev Immunol) How the Immune System Works A Commotion in the Blood Immune merchandise Image credit Letters read on Immune 9 Weekly Sci...
Jun 20, 2018•1 hr 35 min•Ep. 9
The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode γδ17 T cells , T cell homeostasis and thermoregulation (Nat Immunol) γδ17 T cells cells at epithelial barriers (Nat Rev Immunol) Image credit Letters read on Immune 8 Weekly Science Picks Steph- Polycystic ovary syndrome and anti-Mullerian hormone...
May 25, 2018•1 hr 19 min•Ep. 8
The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's (Science) Superresolution structured illumination microscopy Image credit Weekly Science Picks Steph- Social Media for Social Change in Science and Structured Illumination Microscopy vide...
Apr 18, 2018•1 hr 13 min•Ep. 7
The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Potent anti-RSV antibodies without somatic hypermutation (Immunity) History of vaccine enhanced RSV disease (Clin Vacc Immunol) Image credit Letters read on Immune #6 Weekly Science Picks Ste...
Mar 16, 2018•1 hr 29 min•Ep. 6
The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Food Allergy (Nat Rev Dis Prim) Maternal allergen sensitization (J Exp Med) Image credit Letters read on Immune #5 Music by Steve Neal . Immune logo image by Blausen Medical . Send your immunology questions and comments ...
Feb 22, 2018•1 hr 41 min•Ep. 5
The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) Engineering immune cells to treat cancer (Cell) Engineering T cells for fungal infections (PNAS) CAR T cells for AIDS (PLoS Path) CAR T cells (NIH) Image credit Letters re...
Jan 23, 2018•1 hr 23 min•Ep. 4
Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Model for dengue ADE (Scitable) Dengue ADE in humans (Science) Dengvaxia discussion ( TWiV 471 ) Bi-specific antibody to Zika virus (Cell) Building Zika Virus Letters read on Immune #3 Weekly Science Picks Cindy - Questions answered about starving p...
Dec 16, 2017•1 hr 19 min•Ep. 3
Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Circadian clocks control lymphocyte trafficking (Immunity) Lymph node image credit Letters read on Immune #2 Weekly Science Picks Cindy - Men ask more questions than women at a scientific conference (PLoS One) Steph - House just voted to ban...
Nov 25, 2017•1 hr 27 min•Ep. 2
Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Leifer Lab at Cornell Stephanie Langel Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res) Fever regulates immunity (Nat Rev Immunol) Macrophage image by Blausen Medical Weekly Science Picks Cin...
Oct 31, 2017•1 hr 6 min•Ep. 1
