Don't just listen to podcasts. Learn from them with transcripts, summaries, and chapters for every episode. Skim, search, and bookmark insights. Learn more
Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts: Vincent Racaniello , Cynthia Leifer , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune cells in the human body (PNAS) Letters read on Immune 73 Time stamps by Jolene . Thanks! Music by Steve Ne...
From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Ellen Rothenberg Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Disco...
Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis , exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts: Cynthia Leifer , Stephanie Langel , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Helminth protects against murine SARS-CoV-2 infection (Sci Immunol) Pandemic spared Africa (ScienceInsider) Letters read...
Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts: Vincent Racaniello , Cynthia Leifer , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Mast cells and immune avoidance behavior (Nature) Immune sensing of food allergens promotes avoidance (Nature) Immunology that underlies picky eating (Nature...
Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: Vincent Racaniello , Cynthia Leifer , and Steph Langel Download Immune 66 (45 MB .mp3, 76 min) Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immunological imprinting (Immunity) COVID-19 vaccine imprinting (bioRxiv) Original antigenic sin (J Inf Dis) Are c...
Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server T cells capable of supernumerary division (Nature) Time stamps by Jole...
Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server COVID-19 immune memory (Imm Rev) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blause...
Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Jonathan C. Kagan Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Approaching the asymptote (Cold Spring Harb...
Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV...
Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode CAR T for SLE (Nat MEd) Maternal gut microbiome induced IgG (Sci Immunol) Long-primed germinal centers (Nature) Fc mediated protection against SARS-CoV-2 VOC (bioRxiv) Dark side of macrophages (Nat Med) Pregnancy a...
De'Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guests D'Broski Herbert Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Immunology of helminth infections (Ann Rev Immunology) Neuroimmune regulatory networks (J Leuk Biol) Every cell is an im...
From SLB22 on the Island of Hawai'i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guests: Julia Bohannon and Musa Mhlanga Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode From the ashes (Richmond Register) Innate immune memory (J Immunol) Epigenetics and metabolism in tr...
Somali and Phil join Immune to discuss their approaches to immunology education. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Sumali Pandey and Phil Mixter Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode ImmunoReach ASMCUE: ASM Conference for Undergraduate Educators (ASMCUE) Upcoming ASM Webinars: free Microedu Live! discussions: Friday, October 14, 1:00 PM Eastern time/10:00 AM Pacific ti...
At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be 'good' or 'bad' in their function. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Mandy McGeachy Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Th17 cytokines in health and disease (Immunity) Time stamps by Jolene . Thanks! Music by ...
Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Gut B cell dysbiosis in ulcerative colitis (Nat Med) Time stamps by Jolene . Thanks! Mu...
Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Bacteria induce skin regeneration via IL-1beta (Cell Host Microbe) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your i...
Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Al Singer Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode T cell FlipFlop mice reveal lineage determination (Nat Immunol) Time stamps by Jolene . Thanks! Music by Steve Neal. Imm...
Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts: Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode KIR+CD8+ regulatory T cells (Science) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send y...
This episode features a discussion on a paper exploring how aging influences chronic outcomes of respiratory viral infections through the regulation of alveolar macrophages and type 2 inflammatory responses. The hosts delve into topics such as the impact of COVID-19 lockdowns on pediatric asthma, experimental design in mouse models, and the role of the microbiome and various immune cells. They also critically analyze data interpretation and suggest future research directions.
Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts: Vincent Racaniello , Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Trogocytosis in Immune 18 B cells steal from dendritic cells (Science) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology...
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Gabriel Victora Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Concerto in B ( TWiV 161 ) Visualizing antibody affinity maturation (Science) Restricted B cell clonality after boosting (Cell) Time stamps by ...
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Nikhil Joshi Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Creation of NINJA mice (Nature Biotech) Time stamps by Jolene . Thanks! Music by Steve Neal. Immun...
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode DNA binding to TLR9 on red blood cells (Sci Transl Med) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send y...
Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Keke Fairfax Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Maternal schistosomiasis impairs offspring immunity (PloS P...
Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Timothy Hand Click arrow to play Download Immune 48 (43 MB .mp3, 71 min) Subscribe (free): iTunes , Google Podc...
The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Antiviral IgA potentiates NETosis (PNAS) Letters read on Immune 47 Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Med...
Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Dampened STING in bats (Cell Host Micr) Lessons from bat defenses (Nature) Bat immune systems (Front Immune) Bats protected from genoto...
On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Letters read on Immune 45 Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Bla...
On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode Intestinal IgA regulates neuroinflammation (Cell) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and ...
On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors. Hosts: Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): iTunes , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode CAR-T cell therapy on Immune 4 Recent CAR-T cell advances (Nat Rev Cancer) Status of CAR-T cell therapy (CancerCo...
