Ibogaine has surged in popularity as a topic due to its potential to target addiction, trauma and more. But as is always the case with sensational topics, much of what you hear may be false. In this episode, we sit down with a world expert on the topic to understand what is known about this powerful molecule and what is still to be discovered as well as risks and opportunities. Dr. Deborah C. Mash is a Professor of Neurology (Emeritus) and Molecular and Cellular Pharmacology at the University of...
Jan 23, 2026•50 min•Season 1Ep. 26
6 Daily Habits to Help Prevent Dementia & Keep Your Brain Sharp | Dr. Austin Perlmutter Dementia and Alzheimer's disease are on the rise — but science shows your daily habits can significantly lower your risk. In this video, physician and brain health expert Dr. Austin Perlmutter shares 6 science-backed strategies to help prevent dementia, protect memory, and keep your brain sharp at any age. These habits address the most important lifestyle factors for brain health: movement, sleep, social ...
Aug 15, 2025•18 min•Season 1Ep. 25
The New Science of Psychedelics for Brain Health 🧠✨ For thousands of years, humans have turned to psychedelic plants and fungi—from psilocybin mushrooms to peyote cactus—for healing, ritual, and transformation. But now, cutting-edge neuroscience is uncovering how these substances may do more than alter consciousness—they may rewire the brain and reduce inflammation in ways that could benefit mental health, cognition, and even longevity. This podcast is sponsored by Lichen Air. I helped start Li...
Aug 15, 2025•14 min•Season 1Ep. 24
Is sugar toxic to the brain? From honey to aspartame, here's the sweet science of sugar and sweeteners for brain health. #health #brain #sugar This podcast is sponsored by Lichen Air. I helped start Lichen Air because air pollution is a top threat to brain health. We build science-backed air purifiers with advanced HEPA-14 filters and large-room capacity for brain wellness. Our industry-leading, third-party tested indoor air purifier removes up to 99.995% of particles of 0.3 microns or smaller (...
Aug 15, 2025•19 min•Season 1Ep. 23
Creatine may boost brain metabolic and immune systems. This is cutting-edge research worth knowing! For all the references/articles I cited: https://www.austinperlmutter.com/post/the-neuroscience-of-creatine #creatine #muscle #memory #neuroscience Check out my newsletter! https://www.austinperlmutter.com/newsletter This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always co...
May 09, 2025•15 min•Season 1Ep. 22
Here's the latest science on brain fog, what may be causing it and the current knowledge about potential therapeutic modalities Check out my newsletter! https://www.austinperlmutter.com/news2
Apr 01, 2025•23 min•Season 1Ep. 21
Here's the latest science on if we should nap, how we should nap and what we should consider for brain health. Full article with references: https://www.austinperlmutter.com/post...https://www.austinperlmutter.com/post/napping-good-or-bad-for-your-brain Check out my newsletter! https://www.austinperlmutter.com/news2 This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always c...
Apr 01, 2025•13 min•Season 1Ep. 21
Food influences cellular aging. Avoiding certain foods may help protect your brain and body from premature aging. I discuss the science around 3 of these foods. Full article with references: https://www.austinperlmutter.com/post... Check out my newsletter! https://www.austinperlmutter.com/news2 This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare...
Feb 21, 2025•15 min
Groundbreaking research connects muscle mass to brain health. In this episode, you'll discover how resistance training may help fight dementia and depression, why metabolic health starts with your muscles, and how specific nutrients and supplements can supercharge both body and mind. For my full free guide to this topic + all the studies I cited, along with a guide to top plant and animal based protein sources, head to https://www.austinperlmutter.com/muscleguide Whether you're looking to future...
Feb 12, 2025•30 min•Season 1Ep. 20
Chronic inflammation is convincingly linked to higher risk of psychiatric disorders. But how, and what can we do about it? We cover: inflammatory cytokines, the inflammatory hypothesis of depression, key pathways acted on by inflammation in the brain and the role of pharmaceuticals and lifestyle factors in acting on inflammatory pathways related to mental health. Check out the below blog for all the references https://www.austinperlmutter.com/post/how-inflammation-worsens-mental-health Check out...
Dec 09, 2024•25 min•Season 1Ep. 19
How Does Coffee Impact Your Brain? In this video we explore Brain Health, Alzheimer's Prevention, Mental Health, Mechanism, Dosing and Metabolism Check out the below blog for all the references https://www.austinperlmutter.com/post/what-coffee-does-to-your-brain Check out my newsletter! https://www.austinperlmutter.com/newsletter This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You s...
Nov 09, 2024•28 min•Season 1Ep. 18
In this episode, I discuss the four major types of brain cells, including neurons, microglia, astrocytes and oligodendrocytes, what they do and their role in brain health. I then discuss the research on what we can do to help optimize their function. Get my Free Guide: 11 Science-Backed Steps to Help Boost Memory and Prevent Dementia: https://www.austinperlmutter.com/memoryguide Check out my free newsletter https://www.austinperlmutter.com/newsletter This content is not intended to diagnose, tre...
Oct 19, 2024•29 min•Season 1Ep. 17
Creatine May Have Brain and Muscle Benefits: Initially popular among athletes for muscle growth and performance, creatine is now recognized for its potential positive effects on brain function. Naturally occurring in the body, especially in muscles, supplementation can significantly boost its levels. Enhancing Brain Function: Studies suggest that creatine supplementation increases brain creatine levels, which may counter mental fatigue and enhance brain energy metabolism. It's particularly noted...
Sep 06, 2024•13 min•Season 1Ep. 6
Alcohol use has been part of human culture for millennia. But modern research has revealed that ethanol may be a major risk for our brain health, and a potential brain booster. So, which is it? #alcohol #health #brainhealth #neuroscience Here's my full take: https://www.austinperlmutter.com/post/what-does-alcohol-really-do-to-your-brain Want more brain science? Subcribe to my newsletter! https://www.austinperlmutter.com/newsletter This content is not intended to diagnose, treat, cure, or prevent...
Jul 20, 2024•15 min
We've all heard about exercise for preventing cardiovascular disease and weight gain. But where is the conversation about lifestyle modification to prevent conditions like depression? We have more than enough data to recommend diet, exercise, sleep and mindful interventions, and given the incredible damage to our health posed by conditions like depression, I think it's high time we give preventive mental health the attention it deserves. Here's the latest research on science-backed ways to boost...
Apr 29, 2024•19 min•Season 1Ep. 5
There are thousands of molecules found in plants that are now known to impact everything from inflammation to the gut microbiome. They're called "polyphenols" and they may help explain why eating more whole plant foods is linked to better overall and brain health. For more, check out my website at Austinperlmutter.com
Jun 09, 2023•18 min•Season 1Ep. 4
All of us hear about "superfoods" and amazing vitamins and minerals that will fix everything from poor memory to our mood. But what does the science say about the traits of the top foods for brain health? Here are some top takeaways: • Food turns into the building blocks for our brains, so eating more high-quality foods may be a good recipe for a higher-quality brain • Foods that are rich in polyphenols and antioxidants may be especially excellent for brain wellness (these are found in higher le...
May 23, 2023•15 min•Season 1Ep. 3
Get the Stuck Out Shorts Your brain uses more energy (by weight) than any other organ in the body. Your 86 billion neurons each contain up to a million mitochondria, responsible for generating power to keep your thoughts and consciousness running. When things go wrong, we may be at higher risk for brain diseases. So how does this complex system work, and what might we be able to do to improve it? Dr. Austin Perlmutter explains. For a comprehensive + user friendly take on brain energy, Dr. Chris ...
May 13, 2023•14 min
A recent study finds that erythritol may be bad for brain health. But how does sugar impact the brain overall, and what does the research say about sugar alternatives? Should we eat more honey? How does the microbiome factor in? For a nuanced conversation specific to the recent erythritol study, check out my blog at austinperlmutter.com/blog
Apr 16, 2023•11 min
Depression is a worldwide issue experienced by hundreds of millions. For years, the main theory of what was going wrong in the brain focused on the neurotransmitter serotonin. This theory is called the serotonin hypothesis, and it's based on a number of data points. But recently, researchers have questioned whether serotonin plays a central or even a major role in depression at all. In this episode, I explore: -The current landscape of depression -The serotonin hypothesis and issues with it -The...
Jul 29, 2022•24 min•Season 1Ep. 16
In this episode of Get the STUCK Out, Dr. Will Bulsiewicz (Dr. B) explores the role of gut health on diseases like autoimmunity, allergy cancer and inflammation. We talk about the best diets to support gut health, and how the microbiome shapes us. We compare different diets (e.g keto and more plant based) for their effects on health and talk actionable strategies to improve gut health. You can find out more about Dr. B's new book on his website, theplantfedgut.com. For more tips and science on h...
May 03, 2022•1 hr 12 min•Season 1Ep. 15
How does nature influence our brain function? In this episode we'll review the science connecting exposure to nature, or "vitamin N" with improvements in general as well as brain health, and the pathways that might help explain some of these findings. We'll cover the connection between nature and stress, the sympathetic nervous system and the immune system, and how our lives spent away from nature may be negatively influencing those pathways. Then we'll dive into the research connecting nature w...
Sep 02, 2021•20 min•Season 1Ep. 14
Deep dive episode! With millions reporting symptoms of brain fog, depression, anxiety and trouble focusing alongside infection with COVID-19, many want to know: how is the virus influencing the brain? In this video, we'll explore: Historical context for microbes influencing brain function. Methods by which SARS-CoV-2 could enter the brain. Evidence for infection in the brain. Alternative explanations for brain-related symptoms related to COVID-19. For more on the confluence between COVID-19, the...
Aug 30, 2021•30 min•Season 1Ep. 13
Neuroplasticity is the brain's ability to change itself over the course of our lives. Impairments in neuroplasticity have been linked to depression, and many antidepressive therapies may actually work in part by boosting neuroplasticity. In this podcast we'll cover: -How neuroplasticity changes over the lifespan -The connection between impaired neuroplasticity and depression psychology -How neuroplasticity maps onto imaging studies in depresssion -How antidepressants may increase neuroplasticity...
Jul 22, 2021•34 min•Season 1Ep. 12
Trauma is certainly a popular topic of conversation these days. But few in this space share the level of expertise offered by Dr. James. S. Gordon. Dr. Gordon has been helping people around the world to understand and heal from their trauma for decades. Listen as he shares his years of clinical and research experience on how trauma manifests in the brain, body and psychological state, and what to do to start healing it. Dr. Gordon's new book Transforming Trauma is exceptional, and we discuss it ...
May 25, 2021•1 hr 4 min•Season 1Ep. 11
Anxiety is one of the most common states of stuckness today, and COVID-19 hasn't made it any better. In this episode I interview psychiatrist Dimitrios Tsatiris about his area of expertise: anxiety. We talk about what the term means, how it manifests, and what to do about it. Dr. Tsatiris is full of wonderful insight about this highly prevalent state, so you don't want to miss this one! You can find Dr. Tsatiris at: Twitter:@drdimitrios or dimitriostsatiris.com ....
Mar 02, 2021•1 hr•Season 1Ep. 10
In this episode, I explore brain health with two physician scientists, Dr. Ayesha Sherzai and Dr. Dean Sherzai. It was one of my favorite conversations, filled with science, philosophy and psychology. We discuss the need for nuance and updated perspectives in scientific recommendations, the importance of listening to the community, and their powerful journey to becoming some of the leading brain health and brain nutrition experts. Be sure to check out their new book, The 30-Day Alzheimer's Solut...
Feb 04, 2021•1 hr 2 min•Season 1Ep. 9
In this episode I speak with Psychiatrist and researcher Dr. Angela Reiersen about her recent publication in JAMA, "Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19." We discuss: -How she stays focused and gets things done -Her research on fluvoxamine (an antidepressant) and COVID-19 -Why we need to go beyond the serotonin receptor in depression -What the sigma 1 receptor is, and why it matters -How sigma 1 agonists may reduce inflammation -The need for ...
Jan 27, 2021•36 min•Season 1Ep. 8
In this episode of GTSO, I interview Wendy Wood, Ph.D. Wendy is a the Provost Professor of Psychology and Business at the University of Southern California and a prolific researcher in the field of habits. Her research addresses the ways that habits guide behavior—and why they are so difficult to break. She's one of the world's experts on habits, and shares some powerful wisdom on how to leverage this information for behavior change. She is author of the book, Good Habits, Bad Habits (2019), whi...
Dec 30, 2020•56 min•Season 1Ep. 7
In this short solo episode, I dissect the concept of plasticity and its role in enabling humans to be successful and adapt to changing environmental pressures. I discuss plasticity as it relates to our psychology, immune function and most notably, our brain function (neuroplasticity). I conclude by explaining why this is so relevant in the age of stress, fear and anxiety inducing content as well as our generally poor dietary choices.
Nov 18, 2020•15 min•Season 1Ep. 6
