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Future Science Group

Taylor & Francis Group•soundcloud.com
Science
Podcast by Taylor & Francis Group
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Episodes

The epigenetic clock

In this episode, supported by Zymo Research, we discuss the epigenetic clock: what is it? How are researchers using it and what are some of the key tools available to study it? Elucidating the link between epigenetics and aging is Keith Booher, Director of Services at Zymo research including aging and epigenetics research services. Keith reveals how our behaviors and environment, such as diet, exercise and air quality, can impact our epigenetics and the impact that the epigenetic clock has playe...

Mar 25, 2022•25 min

Hybrid assays: an interview with Barry Jones and Adriane Spytko

In this podcast Barry Jones (Director, LC–MS Biologics and Biomarkers at Q² Solutions) and Adriane Spytko (Manager, LC–MS Biologics at Q² Solutions; both NY, USA) discuss hybrid assays using both LBA and LC−MS techniques. They share their thoughts on bottom-up LC−MS methods and the concern about detecting analyte that is not intact as well as future projects that bridge LC−MS and LBA.

Mar 11, 2022•11 min

Resolving spatial biology in neuroscience

In this episode of Talking Techniques, supported by Resolve BioSciences, we explore the realm of spatial biology, with a particular focus on the techniques involved in this approach to biological exploration, and the exciting insights gleaned from these techniques that have led to this approach being labeled Natures Method of the year 2020! Stefano Pupe, Postdoctoral Researcher at German Center for Neurodegenerative Diseases, takes me through this field, revealing – amongst other fascinating ins...

Feb 28, 2022•30 min

Introducing STEM Tea

In this episode of Talking Techniques, we introduce a new podcast series, produced by BioTechnques and hosted by the enigmatic Antentor Othrell Hinton Jr, Assistant Professor of Molecular Physiology and Biophysics at the Vanderbilt University, and bring you a sneak peek of the first episode of the series. In this podcast series, Antentor will discuss all things diversity, equity and inclusion in STEM, meeting with different guests each episode from across the spectrum of fields and people in the...

Feb 17, 2022•35 min

Cell proliferation in drug screening

In this episode, supported by BioRad, we explore cell proliferation monitoring and its role in drug discovery, guided by the expert advice of Rachel Preston, Product Development researcher at Bio-Rad. We discuss techniques available to monitor cell proliferation, their advantages and disadvantages and the importance of selecting the right combination of techniques for different experimental targets. Rachel also provides some tips for best practice and some pitfalls to avoid regarding DNA damage ...

Jan 25, 2022•21 min

Tech Blast: Sanger sequencing

In this Tech Blast episode, is Jay Lemke, Senior Research Scientist at Promega, provides a brief overview of Sanger sequencing, its history, working principle and development over the last half century. Jay reveals which lab practices are still are best completed with Sanger sequencing and explains why the technique remains so prevalent today, even in the era of next-generation sequencing. Get Jay's top tips for best practices when working with sanger and much more throughout the episode! Conten...

Jan 18, 2022•13 min

Treatment options for thyroid cancer: an interview with Kate Newbold

Find out about current treatment options for thyroid cancer such as the recent approval of selpercatinib for patients with an alteration in the RET gene in this interview with Kate Newbold who is a clinical oncologist consultant at The Royal Marsden Hospital in London (UK).

Jan 10, 2022•10 min

Synthetic biology: from cancer to the climate crisis

In this episode, we explore the field of synthetic biology. Discover the history of the field and its origins in the production of biofuels, before fracking burst onto the scene forcing a pivot in direction towards chemical production. Find out about the key techniques that have brought synthetic biology into the realm of immunotherapies and cancer research, which have even welcomed in a return to applications focussed on tackling the climate crisis, such as lab-grown meat. To investigate this s...

Dec 21, 2021•26 min

Tech Blast | Quality assurance in drug discovery

In this Tech Blast episode, Tim Bolus, Compliance Program Manager at Molecular Devices, provides a 15-minute in-depth exploration of the regulatory landscape of drug discovery and development. Tim examines the good lab and manufacturing processes essential to successful drug discovery, development and production. Get Tim's insight into the field and discover how to best prepare your lab to pass the FDA's regulations and hear some firsthand cautionary tales! Contents: Introducing GXP: 00:40-2:20 ...

Dec 16, 2021•14 min

Establishing an epigenetic lens through which to explore infectious disease and cancer

We are talking all things DNA methylation in this episode, providing a brief explanation of epigenetics and the technologies involved in the study of DNA methylation, before exploring the application of these techniques in the study of infectious diseases and cancer. Revealing all of this information is my guest Chloé Goldsmith, Postdoctoral Research Fellow at Canberra University, whose research focuses on DNA methylation, Hepatitis B Virus and the link between lifestyle and the epigenome. Chloé...

Nov 12, 2021•24 min

Target enrichment for NGS: Why, how and what's next?

In this episode, supported by Roche, we explore a vital aspect of many next-generation sequencing studies: target enrichment. Here, regions of interest are selectively amplified before sequencing takes place. More specifically we examine some of the new technologies improving this key step and their impact on oncology research. My guest for this episode is Brian Godwin, Director of Reagent and Assay Development at Roche sequencing. Brian reveals the myriad of ways that poor target enrichment can...

Oct 26, 2021•18 min

Producing challenging proteins in the golden age of protein engineering

In this episode, we roam the world of recombinant proteins and their production, discussing the challenges of their production, and recent evolutions in protein engineering that have brought the field into a golden era of innovation. I'm joined by recombinant protein engineering expert Yuning Chen, R&D Manager at Sino Biological, who discusses the key applications of recombinant proteins, the aspects of certain products that make them difficult to produce and how these difficulties can be ov...

Oct 13, 2021•20 min

The evolution of PCR: From q to dd and beyond

PCR has evolved rapidly over the last few years, an evolution that has been dramatically accelerated by the COVID-19 pandemic. New technologies and approaches have been brought to the fore and the full range of applications for which this technique can be applied have been highlighted, from diagnostics to basic disease research and immunology. This episode explores this evolution, looking at how challenges presented by the pandemic forced the hand of researchers to think outside the box and buil...

Sep 21, 2021•25 min

Revitalising the western blot

Love it or hate it, western blotting forms the bedrock of countless studies across numerous disciplines. Explore its history, development and applications in this episode all about the marmite of life science techniques. Guiding me through the hand wringing, hair follicle destroying history and process of western blotting, and hopefully explaining the beauty and potential of the technique - is Kenneth Oh, Senior Project Manager at Bio-Rad Laboratories. Kenneth reveals some of the latest developm...

Sep 07, 2021•22 min

Molecular therapeutics: how far have we come and what is on the horizon?

Uncover the history of molecular therapeutics, the staggering current applications and developments of these therapeutics and what their future could hold, in this episode of Talking Techniques. To explore the field of molecular therapeutics and provide an insight into their production, is Aaron Clauson, Product Manager at Zymo research. First, we cover the ins and outs of targeting the therapies and how to select the correct type of molecular therapeutic to begin developing a drug for a specifi...

Aug 27, 2021•38 min

Adeno-associated viral therapies: harnessing the power of HPLC

This episode centers on the critical role that high-performance liquid chromatography (HPLC) plays in the production of adeno-associated viral (AAV) therapies, the latest advances in AAV design and the next steps in their development. Filling me in on all things HPLC and AAVs is Bella Neufeld, Director of R&D at Teknova. Bella reveals the essential validation and quality control steps required for the production of successful and safe AAV therapies and the role that both HPLC and liquid chro...

Aug 18, 2021•20 min

Organoids: advancing drug discovery and cancer research

As the transition from 2D to 3D cell cultures, or organoids, as the gold standard for modeling basic biology and disease continues, these models are being utilized in ever more intricate and impactful ways. This episode covers the rise of organoids and their advantages over 2D cell cultures, before exploring just how representative these models are becoming and their new applications in drug discovery. To find out all this and more, I speak to Oksana Sirenko, Senior Scientist at Molecular Device...

Aug 16, 2021•33 min

Taking an assay from bench to an automated platform: a podcast with Jason Evans

In this podcast interview, Jason Evans (Scientist at Q² Solutions; NY, USA) discusses the importance of automation and key advantages of taking an assay from the bench to an automated platform. He also explains the increase in throughput when his lab transitioned to automated assays and the hurdles he faced when automating assays.

Jul 23, 2021•11 min

The ethics of whole-genome sequencing: from race and religion to science fiction

Welcome to part 2 of this two-part episode on whole-genome sequencing (WGS) in rare disease research and treatment. In part one we discussed the impacts the technology has had on both improving the clinical diagnosis and management of rare diseases and on drug development and basic research studies. This episode goes beyond the technology's capabilities and into the debates surrounding how, when and why they should be used. What needs to change for the technique to be applied equitably? And how ...

Jun 25, 2021•27 min

Revitalising the western blot

Love it or hate it, western blotting forms the bedrock of countless studies across numerous disciplines. Explore its history, development and applications in this episode all about the marmite of life science techniques. Guiding me through the hand wringing, hair follicle destroying history and process of western blotting, and hopefully explaining the beauty and potential of the technique - is Kenneth Oh, Senior Project Manager at Bio-Rad Laboratories. Kenneth reveals some of the latest developm...

Jun 21, 2021•22 min

From space to the streets: infectious disease sampling in extreme conditions and extraordinary circumstances

In this episode, we take a look at one of the key steps of infectious disease research, sample collection; exploring the challenges associated with the step and the solutions available to improve infectious disease research around the globe. Exploring the trials and tribulations of infectious disease sample collection with me is Stanislav Forman, Product Developer at Zymo Research (CA, USA). Stan explains the extreme environments in which sample collection often occurs; revealing the difficult t...

Jun 18, 2021•19 min
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