Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.

Last refreshed: July 2nd, 2025 at 8:13 PM ⓘ

Follow this podcast in the Metacast mobile app to refresh it and see new episodes.

Follow on

Apple Podcasts

Spotify

RSS

Podcasts are better in Metacast mobile app

Don't just listen to podcasts. Learn from them with transcripts, summaries, and chapters for every episode. Skim, search, and bookmark insights. Learn more

Episodes

BioMedical Portrait III. c8. Unique mRNA upstream open reading frames direct both the integrated stress response and rare selective up-regulation of stress-correcting protein synthesis.DJGPhD.21.9.23

References Dr Guerra's lectures RNA Biol. 2023; 20(1): 737–749

Sep 21, 2023•30 min

BioMedical Portrait III.c.7 Elementary polypeptide synthesis-translation. Lecture 1. DJGPhD.20.9.23.Authentic Biochemistry Podcast.

Reference Dr Guerra's lecture notes

Sep 20, 2023•30 min

BioMedical Portrait III. c6. Adipokine and the succinate receptor systems in obese adipose inflammation as regulated by AMPK.DJGPhD.19.9.23. Authentic Biochemistry Podcast

References Cream 1968 Wheels of Fire J Neuroinflammation. 2019; 16: 34. Front Immunol. 2019; 10: 345. Cell Metabolism 2023. Volume 35 Issue 4. 601-619.e10 Sci Signal. 2017 Jan 31; 10(464):eaaf7478

Sep 20, 2023•30 min

BioMedical Portrait III.c.5. Adipokine mediated adipose inflamation is linked to the hypothalamic control over metabolism and systemic inflammation.DJGPhD.18.9.23.Authentic Biochemistry Podcast

References Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Int J Biol Sci. 2015; 11(11):1272–1280 Front. Physiol., 01 June 2018 Int. J. Mol. Sci. 2019, 20(6), 1505 Front Immunol. 2023; 14: 1149366

Sep 18, 2023•30 min

BioMedical Portrait III. c.4. Adipose tissue macrophages express galectin binding proteins which alter immunosuppression and polarization;adipokines mediate the inflammatory response. DJGPhD.17.9.23

References Luigi Boccherini: Symphony Op. 12 No. 4 in D Minor JCI Insight. 2016 Nov 17; 1(19): e87748 Front Immunol. 2023; 14: 1149366 Adv Biol Regul.2019 Jan;71:41-54. Int. J. Mol. Sci. 2019, 20(6), 1505

Sep 17, 2023•29 min

BioMedical Portrait III. Immunometabolic disease 3c.Reactive N and O interconversions in obese adipose exacerbate systemic inflammation. 17.9.23. DJGPhD. Authentic Biochemistry Podcast.

References Inn Med (Heidelb). 2023 Apr;64(4):313-322. JBC 2001. Volume 276, Issue 31, August. Pages 28799-28805.

Sep 17, 2023•30 min

BioMedical Portrait III. Immunometabolic disease. The obesity-compromised adipose poise to hyperinflammation. DJGPhD. 15.9.23. Authentic Biochemistry.

References Schubert, Franz. 1824. March.String Quartet #14 in D minor, D.810 Hypertension. 2002;39:1088–1094 Physiol Rev. 2018 Apr1;98(2):641-665.

Sep 15, 2023•30 min

BioMedical Portrait III. c1. Immuno-metabolic disease. Dr. Daniel J. Guerra. 14.9.23. Authentic Biochemistry Podcast.

References Schubert. F. 1826. "Ständchen" D.899 Immunol Rev. 2020 May; 295(1): 101–113. Nat Metab. 2022 Sep;4(9):1202-1213

Sep 15, 2023•30 min

Biochemical Energetics. Elementary Considerations chapter2. DJGPhD. 13.9.23 Authentic Biochemistry Podcast

References Biochemistry lectures: Guerra archives

Sep 13, 2023•29 min

Biochemical Energetics I Elementary Considerations. DJGPhD 12Sept23. Authentic Biochemistry Podcast.

References Biochem lecture notes

Sep 12, 2023•30 min

BioMedical Portrait II. Hashimoto's Thyroiditis prevalence in women linked to mitochondrial electron transport chain activity, ATP/ADP translocation, and potent autoantibodies to thyroid peroxidase.

References Journal of Immunology Research Article ID 8263829 JAMA. 2021 Jun 15; 325(23): 2392–2393. Thyroid. 2014 Feb 1; 24(2): 371–382. Pol Arch Intern Med. 2022 Mar 30; 132(3): 16222. FEBS Letters.1997. (414): 258-262

Sep 10, 2023•30 min

BioMedical Portrait II. c.14. Predominance of Hashimoto's Thyroiditis in Women: is there a link to the decreased expression of TLR7 and the AMPK-alpha/Id3 axis on CD8+TE and Treg activity?

References Mozart - Flute and Harp Concerto in C, K. 299 J Immunol Res. 2021; 2021: 8263829. J Immunol. 2022 Jan 1;208(1):155-168 Front. Immunol. 2022.31 March. Sec. Molecular Innate Immunity Volume 13 –202. Cells. 2022 Mar; 11(6): 997 Nature Immunology 2020. volume 21, pages1256–1266. Nature Immunology 2011. 12 (12) 10.

Sep 10, 2023•30 min

BioMedical PortraitII. c13. Female prevalent autoimmune RA-macrophage STAT3(TF) and NaMPT(NAD+ salvage pathway) promote rheumatoid arthritis & primer on thyroiditis

References Cells. 2022 Mar; 11(6): 997. Nat Cell Biol. 2019 Mar; 21(3): 397–407. Rheumatology (Oxford). 2023 Jul; 62(7):2611–2620

Sep 09, 2023•30 min

BioMedical Portrait II. C12. Lupus is far more common in women than men due to TLR7 enhancement and Rheumatoid Arthritis is more common in women due to macrophage bioeneregtic phenomenaDJGPhD.7Sept23

References Rheumatology (Oxford). 2023 Jul; 62(7):2611–2620 Science Immunology.2018.26 Jan Vol 3, Issue 1. Nature. 2020 Jun; 582(7813): 577–581.

Sep 08, 2023•30 min

BioMedical Portrait II.c11. Autoimmune diseases like lupus are far more prevalent in women due to the lack of X chromosomal allelic inactivationof TLR7's. DJGPhD.7Sept23.Authentic Biochemistry.

References Nature. 2020 Jun; 582(7813): 577–581 Science Immunology 2018.26 Jan Vol 3, Issue 1

Sep 07, 2023•30 min

Biomedical Portrait!!,c.10 Older women have more reactive oxygen and fewer functional mitochondria and DNA content than older men or younger women.DJGPhD.5Dept2023. Authentic Biochemistry Podcast.

Reference The Journals of Gerontology: 2019. Series A,Volume 74, Issue 12, Pages 1887–1895

Sep 05, 2023•30 min

BioMedical Portrait II. c9. Autoimmune diseases are more common in women than men: immune response triggering and the possible role of bioenergetics.DJGPhD.3sept23.Authentic Biochemistry.

References Endocrinology. 2012 Jun; 153(6):2544–2550. Redox Biol. 2020 Apr; 31: 101482

Sep 03, 2023•30 min

BioMedical Portrait II. C.8. Alterations in sphingosine metabolism linked to breast cancer staging in women and progression of NAFLD to NASH and HCC is much lower in women until menopause.DJGPhD.

References Lipids 3 May 2022. Volume57, Pages 183-195 Front Immunol . 2023; 14: 1116839 Mol Metab. 2022 Aug; 62: 101523 Nature Reviews Molecular Cell Biology 2018. volume 19 , pages 175–191...

Sep 02, 2023•30 min

Biomedical Portrait II. C.7. Serum sphingolipid molecular speciation in women differs from men but association with tissue endomembranous lipid components fail to be addressed.DJGPhD. 31.8.23

References Aging (Albany NY). 2019 Jan 15; 11(1):73–88.

Aug 31, 2023•30 min

BioMedical Portrait II. Metabolic and Bioenergetic distinction between men and women includes lipid deposition and utilization mechanisms.DJGPhD.30.8.23.Authentic Biochemistry Podcast.

References Front. Endocrinol.2015 Sec. Clinical Diabetes Obes Sci Pract. 2017 Mar; 3(1): 106–114.

Aug 30, 2023•30 min

BioMedical Portrait II, c.5. Muscle fibre sexual dimorphism obtains networks of genetic, epigenetic, and biochemical events.DJGPhD.29.8.23 Authentic Biochemistry Podcast

Reference BMC Genomics. 2022; 23: 519

Aug 29, 2023•30 min

Biomedical PortraitII.C.4 THe sexual dimorphism of bioenergetics: introduction to carbon utilization. Video lecture link

https://youtu.be/llYhGi1XSvU

Aug 28, 2023•2 min

BioMedical Portrait II. Chapter 3. Mitochondrial gene expression, lipid metabolism and cell fate are at least partiatially mediated by Fragile X protein competency. DJGPhD.24.8.23

References Scientific Reports 2015.volume 5,Article number: 15292 Dev Cell. 2023 Apr 10;58(7):597-615.e10

Aug 24, 2023•30 min

BioMedical Portrait II. The Fragile X Syndrome. Discovery and subsequent association with the FMR1 gene. Premature Ovary Failure I vs. heritable intellectual disabilities DJGPhD.22.8.23

References Genes & Immunity 2021. volume 22, pages 125–140. Prz Menopauzalny. 2017 Jun; 16(2):51–56. J Neuroinflammation. 2016 May16;13(1):109. Am J Physiol Cell Physiol 2022. 322: C125–C135 Adv Human Genetics 1983.13:83 Ann NY Acad Sci . 1986. 477:129 Neurol Neurosurg Psychiatry.1943. 6:154

Aug 23, 2023•30 min

BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation

Reference J Hum Evol. 2022 Oct; 171: 103229.

Aug 21, 2023•30 min

BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23

References Immunity 2021. 54, 2273–2287 Front Immunol. 2020. 11: 784

Aug 19, 2023•30 min

Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP.

__ [Mol Neurobiol] 2020 Jun; Vol. 57 (6), pp. 2654-2670 Oncol Rep. 2023 May;49(5):93

Aug 18, 2023•30 min

BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD

References Steroids. 2022 Sep;185:109053 Trends Neurosci. 2015 Jun; 38(6): 364–374 Progress in Molecular Biology and Translational Science Volume 168.Pages 257-275 Histol Histopathol. 2018 Jan; 33(1): 1–10.

Aug 17, 2023•30 min

BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry

References Histol Histopathol. 2018 Jan; 33(1): 1–10 J Steroid Biochem Mol Biol. 2022Feb;216:106040 Steroids. 2022 Sep;185:109053

Aug 16, 2023•30 min

BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD.

References J Steroid Biochem Mol Biol. 2022. Feb;216:106040. Steroids. 2022 Sep;185:109053

Aug 14, 2023•30 min

← Prev Next →

Hosted on Spotify for Creators (Anchor)

For the best experience, listen in Metacast app for iOS or Android