Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

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Episodes

BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23

References Alzheimer's Research & Therapy 2021. volume13, Article number: 56. Progress in Molecular Biology and Translational Science 2019. Volume 168 #

Aug 14, 2023•29 min

BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD

References Genes & Immunity 2021 volume 22, pages 125–140 Arch Endocrinol Metab. 2022 Jan-Feb; 66(1): 77–87 Essays Biochem. 2021 Nov; 65(6): 913–925

Aug 13, 2023•30 min

BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD.

Reference Journal of Cognitive Neuroscience (2022)34 (8): 1500–1520

Aug 11, 2023•30 min

BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD

References Mol Neurobiol 2020 Jun; Vol. 57 (6), pp. 2654-2670 Brain Res. 2009 Sep 22; 1290: 1–11. JAMA.2003;289(20):2651-2662.

Aug 09, 2023•29 min

Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB.

References JAMA.2003;289(20):2651-2662. Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Psychiatry. 2019 Sep 15;86(6):421-432

Aug 08, 2023•30 min

BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection.

References Essays Biochem. 2021 Nov; 65(6): 913–925 Front. Endocrinol. 2022. AUGUST. v.13 .Sec. Molecular and Structural Endocrinology

Aug 07, 2023•30 min

BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23

Reference Essays Biochem. 2021 Nov; 65(6): 913–925

Aug 05, 2023•30 min

BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23

References Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Sex Differ. 2023; 14: 34.

Aug 05, 2023•30 min

BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry

References Biol Sex Differ. 2023; 14: 34 J Cell Sci 2005;118:4605-4612 EBioMedicine. 2015 Dec; 2(12): 1888–1904 PLoS Genet. 2013 Jun; 9(6): e1003556

Aug 03, 2023•30 min

From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast

Reference Some light on the forest floor of wisdom

Jul 31, 2023•30 min

The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast

References Experience et al.

Jul 30, 2023•30 min

ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry

References Mol Cancer. 2023 Apr 10;22(1):69 Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415 Semin Immunol. 2010 Dec; 22(6): 311–312

Jul 30, 2023•30 min

ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast.

Reference Front Immunol.2022; 13: 890056. previous IE lectures 1-3.

Jul 28, 2023•30 min

ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD

Reference Cancers (Basel). 2021. Apr; 13(8): 1850.

Jul 27, 2023•30 min

ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression.

References NPJ Vaccines. 2018; 3: 23. Immunol Cell Biol. 2022 Aug; 100(7): 562–579

Jul 26, 2023•30 min

ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23

References Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234. Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195

Jul 24, 2023•30 min