Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast.
References Guerra. Plant Biochemistry lectures
Jul 05, 2023•30 min
Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
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Episodes
Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions)
Reference Organic chemistry : reaction mechanism lectures
Jul 04, 2023•30 min
Unique Lecture Series . Holiday Time. 4th of July 2023! Hydrocarbons.
Very basic lecture material
Jul 01, 2023•30 min
ImmunoEpigenetics 89. Final synthesis of statin drug mediated alteration of metabolism in T lymphocytes. DJGPhD.6.30.23. Authentic Biochemistry Podcast.
References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Previous 5 lectures in Authentic Biochemistry and refs. contained therein https://youtu.be/dyy0p90GO2w
Jun 30, 2023•30 min
ImmunoEpigenetics 88. Statin treatment of early progenitor T cell acute lymphoblastic leukemia could pose biochemical impositions on healthy lymphocyte populations. DJGPhD.29.6.23.Authentic Biochem.
References Oncotarget 2021.12.(13) Cancers (Basel). 2020 Aug 1;12(8):213 Cancer Discov. 2022 Mar 1; 12(3): 856–871
Jun 30, 2023•30 min
ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture.
References JBC.2002. Volume 277, ISSUE 2, P1128-1138. Cancer Discov. 2022 Mar 1; 12(3): 856–871. Guerra lectures-lipid metabolic regulation Guerra lectures-pharmacodynamics and kinetics
Jun 28, 2023•30 min
ImmunoEpigenetics86. Could regimented titrating statin pharmacotherapy be useful in controlling early T lymphoid progenitor cell ETP-ALL via an epigenetic mechansim? DJGPhD.27.6.23. Authentic Biochem
Reference Cancer Discov. 2022 Mar 1; 12(3): 856–871.
Jun 28, 2023•29 min
ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23
References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Sci Signal. 2015 Mar 31;8(370):re4
Jun 25, 2023•29 min
ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD.
References J Exp Med. 2017 Jul 3;214(7):1861-1876 Immunol Rev. 2014 Sep;261(1):62-83 Int J Mol Sci. 2022 Mar; 23(5): 2878. Immunity 2022. Volume 55, Issue 8. :1402-1413.e4
Jun 24, 2023•30 min
ImmunoEpigenetics 83. Epistemic and metaphysical considerations of immune cell epigenetic reprogramming obtaining biochemical event ontologies. DJGPhD.23.6.23. Authentic Biochemistry Podcast
References Guerra: logical propositions and dialectical syntheses Annual Review of Immunology2021. Volume 39: 279-311
Jun 23, 2023•30 min
ImmunoEpigenetics82.Innate lymphoid progenitor antibody-directed single cell DNAse hypersenitive site analysis of transcription factor specific histone methylation and acetylation modifications.DJGPhD
References Nat Protoc. 2017 Nov;12(11):2342-2354 Annual Review of Immunology 2021. Volume 39. pp 279-311 Immunity 2022. Volume 55, Issue 8. Pages 1402-1413.e4
Jun 23, 2023•29 min
ImmunoEpigenetics 81.Innate lymphoid cells lack antigen receptors and are differentiated into multiple linneages via epigenetic priming of nucleosomal regions proximal to cell-specific TF's.DJGPhD.
References Immunity 2022. 55, Issue 8. Pages 1402-1413. Methods Mol Biol. 2018;1675:167-181. Experimental & Molecular Medicine 2019. volume 51, Article number: 80. Cell Reports 2015 10, 2043-2054DOI: (10.1016/j.celrep.2015.02.057)
Jun 22, 2023•30 min
ImmunoEpigenetics80.T lymphocyte biochemical communications are triggered epigentically and via membrane lipid molecular species recombination: A dialectical event ontological view. DJGPhD.17.6.23
Reference Authentic Biochemistry Lecture synthesis
Jun 18, 2023•30 min
ImmunoEpigenetics79. T lymphocyte DPPA induced HSP27 deoligomerization-activating DGK-a associated anergy is linked to cancer cell proliferation phenotypes. DJGPhD.16.6.23b Authentic Biochemistry
Reference J BiolChem. 2023 Mar; 299(3): 103019.
Jun 17, 2023•30 min
ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast
References J Biol Chem 2017 292: 20481. Critique if Pure Reason.1781. Kant,I. Guerra,2023. manuscripts in preparation
Jun 16, 2023•30 min
ImmunoEpigenetics77. T cell membrane phospholipase D mediated PA deprotonation as a biosensor for an electrostatic/hydrogen-bond signal transductionDJGPhD.15.6.23. Authentic Biochemistry Podcast.
References The Journal of Biological Chemistry 2007.282,11356-11364. BMC Biology 2011. 9:85 Cancer Res . 2011 Jan 15;71(2):293-7. J BiolChem. 2023 Mar; 299(3): 103019.
Jun 16, 2023•29 min
Interum lecture VI. Entropic forces and the ergodic hierarchy of GPCR-linked phsopholipase phase space postioning temporality. DJGPhD.13.6.23
References ACS Omega. 2019 Nov 26; 4(22):19526–19547 Guerra: general thermodynamics lectures
Jun 14, 2023•30 min
Interum Lecture V. Semi-closure on free energy and enthalpic involvement in leptin/AMPK mediated orexigenic states . DJGPhD.12June23.Authentic Biochemistry Podcast
Reference Guerra lecture material
Jun 12, 2023•30 min
Interum Lecture IV. MBD:DNAMolecular Dynamics video lecture!
https://youtu.be/O2CpwFLy0zI
Jun 12, 2023•1 min
Interum Lecture III. Protein methylation binding domain association with substrate CpG alters equilibrium torsion angle (epsilon-zeta) conformational states via enthalpic-free energy conservation.
References Mol Informatics. 2012 Feb;31(2):114-22. Nat Struct Mol Biol. 2017 Jun; 24(6):544–552 Guerra: chemical thermodynamics lectures
Jun 11, 2023•30 min
Interum Lecture II. Rates of reactions in living systems.DJGPhD.8June2023 Authentic Biochemistry Podcast
References Guerra-lecture notes and marginalia
Jun 09, 2023•30 min
Interrum lecture I. Obesity unsuccessfully violates the first law of thermodynamics.
References Guerra: Faculties of reason
Jun 07, 2023•30 min
ImmunoEpigenetics 76. Sphingolipid metabolism and S1P receptor expression linked to multiple potentiating immunoinflammatory obese associated pathophysiologies. DJGPhD.6June23B AuthenticBiochemistry
References Dr. Guerra-graduate lipid lectures Nutrients.2022 Jun 12;14(12):2438 Endocrinology. 2006 Dec;147(12):5835-44 The International Journal of Biochemistry & Cell Biology 2019. Volume 114, 105564
Jun 07, 2023•29 min
ImmunoEpigenetics 75. Sphingolipid receptor molecular discernment from exosome cargo mediated control involves M1 to M2 polarization shift post myocardial infarction induced fibrosis. DJGPhD.6June23
Reference The International Journal of Biochemistry& Cell Biology Volume 114, 105564.
Jun 06, 2023•30 min
ImmunoEpigenetics74.The methylation-specific epigenetic control over adipose tissue macrophage polarity is axially supported by leptin induced CNS control over satiety and pancreatic insulin secretion
References JCI Insight. 2016 Nov 17; 1(19): e87748. Graduate Biochemistry lecture archives-Guerra Nutrition. 2020 Oct;78:110935.
Jun 05, 2023•30 min
ImmunoEpigenetics 73. The dialectical synthesis of adipose PPAR-gamma mediated fatty acid binding protein4 expression in foam cell formation and subsequent adipokine contribution to insulin secretion
References Cells. 2019 Mar; 8(3): 227 Chest. 2016 Jul; 150(1): 91–101 JCI Insight. 2016 Nov 17; 1(19): e87748.
Jun 05, 2023•30 min
ImmunoEpigenetics72. Chemistry of reactive oxygen/nitrogen radical species as adipose pathobiochemical sequalae to obesity via M1 macrophage polarity involving adipose and vasculature pathophysiology.
References Inn Med (Heidelb). 2023 Apr;64(4):313-322 JBC 2001.Volume 276, Issue 31, Pages 28799-28805 Frein, Daniel. 2006. “Signaling and Redox Regulation by Nitric Oxide, Superoxide and Carbon Monoxide.” Hypertension. 2002;39:1088–1094 Nat Metab. 2022 Sep;4(9):1202-1213 JCI Insight. 2016 Nov 17; 1(19): e87748
Jun 03, 2023•30 min
ImmunoEpigenetics 71. Insulin receptor corruption is mediated by high circulating fatty acids, in situ DAG-PKCepsilon induced phosphorylation and membrane protein aggregation in obese diabetics.DJGPhD
References Guerra Biochemistry lecture archives Nat Metab. 2022 Sep;4(9):1202-1213 Mol Cell. 2008 May 23; 30(4): 403–414 J Clin Invest. 2016 Nov 1; 126(11):4361–4371. Front Immunol. 2021; 12: 746151.
Jun 02, 2023•27 min
ImmunoEpigenetics 70.Obesity-linked adipose resident macrophage (M1)polarization meta-inflammation leads to Insulin Resistance via fatty acid oxygenation in situ. DJGPhD.01June2023.Authentic Biochem.
References Graduate Biochemistry lectures-Guerra Front Immunol. 2021; 12: 746151
Jun 02, 2023•30 min
Intermediary Metabolism Lecture. Covalent modification of enzymes and transcription factors alter bioenergetics and the pro-inflammatory response in obese vs. healthy patients.31.5.23 DJGPhD
References Guerra general graduate biochemistry lecture Immunol Res. 2020 Feb;68(1):28-38. doi: 10.1007/s12026-020-09125-9.
May 31, 2023•30 min
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