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May 26, 2023•1 min
Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
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Episodes
ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency.
References Journal of Experimental & Clinical Cancer Research 2022.volume 41, Article number: 303. Protein Cell. 2021 Apr; 12(4): 240–260. J Cell Biol (2022) 221 (11): e202202011.
May 25, 2023•30 min
Graduate Biochemistry Lecture III. Dietary lipid control over neuroendocrine system involves multiple organ systems in contact with immune surveilance. DJGPhD. 24.5.23B Authentic Biochemistry
References Dr. Guerra's lecture archives.
May 24, 2023•30 min
Graduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.
References Dr. Guerra's lipid lectures J Diabetes Investig. 2019 Nov; 10(6): 1430–1437.
May 24, 2023•30 min
Special Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.
Reference Dr Guerra: Graduate Biochemistry lecture material.
May 20, 2023•30 min
ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters
References Arterioscler Thromb Vasc Biol . 2021 Jan;41(1):153-166. Clinical Epigenetics 2021. volume 13, Article number: 7. https://www.sciencedirect.com/topics/immunology-and-microbiology/foam-cell
May 18, 2023•30 min
ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD
References JLR 2014 55(6) Pages 1165-1172. JLR 2018 59(6): 1058–1070.
May 16, 2023•30 min
ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.
References PLoS ONE 2012. 7(4): e3440 Steroids 2021. Volume 172, August, 108854 Antioxidants 2019, 8(5), 126
May 16, 2023•30 min
ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.
References Free Radical Biology and Medicine Volume 71, June. Pages 1-15 Cardiovasc.Res. 2012 May 1; 94(2): 379–390. Int. J. Mol. Sci. 2020, 21 (7), 2578; https://doi.org/10.3390/ijms21072578
May 14, 2023•30 min
ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means
References Free Radical Biology and Medicine 2014. Volume 71, June.Pages 1-15 J Mol Endocrinol. 2020 Nov; 65(4): R77–R90. REDOX and Cholesterol metabolism lectures-Dr Guerra
May 12, 2023•30 min
ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites
References Cancers (Basel). 2019 May; 11(5): 678. Oncogene.2017 Mar 23; 36(12): 1607–1618 Dr Guerra's annotated lecture notes from graduate biochemistry course(s)
May 10, 2023•29 min
ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD
References Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9 Cancer Drug Resist 2020;3:762-74. Oncogene.2017 Mar 23; 36(12): 1607–1618 Front Immunol. 2020; 11: 1782.
May 10, 2023•30 min
ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.
References Dr Guerra Intermediary metabolic lecture notes-graduate biochemistry lecture archives Epigenetics. 2019; 14(12): 1183–1193. Drug Discov Today. 2017 Jan; 22(1): 186–193.
May 09, 2023•30 min
Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast
References Int J Mol Sci. 2020 Jun; 21(11): 4098.
May 07, 2023•30 min
ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23
References Int J Mol Sci. 2020 Jun; 21(11): 4098. Authentic Biochemistry lectures :ImmunoEpigenetics 56-58
May 06, 2023•30 min
ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSG's advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem.
References BMC Medical Genomics. 2015. volume 8, Article number 45. Journal for ImmunoTherapy of Cancer 2022;10:e003826.
Apr 28, 2023•30 min
ImmunoEpigenetics 57. Plasmacytoid dendritic cell neoplasias and the CAR-T cell tumor microenvironment exposure altering epigenetic TF regulation leading to diverse differentiation. DJGPhD.20.4.23
References Current Oncology Reports. 2020. 1534-6269, May 15, Vol. 22, Issue 6. Cell. 2021 Dec 9; 184(25):6081–6100.e26.
Apr 21, 2023•30 min
ImmunoEpigenetics 56. Dendritic cell immunobiochemistry introductions. DJGPhD. Authentic Biochemistry 15.4.23
References Autoimmunity. 2012 Aug;45(5):333-47 Clinical and Experimental Rheumatology 2019: One year in review 2019: systemic lupus erythematosus Trends in Immunology, 2021-01-01, Volume 42, Issue 1, Pages 59-75 Annu. Rev. Immunol. 2000. 18:767–811
Apr 15, 2023•29 min
ImmunoEpigenetics55. ILC and Treg differentiation is mediated by acetylation and methylation epigenegtic authorship at discrete TF binding site domains.DJGPhD.14.4.23. Authentic Biochemistry
References Cell Reports 2015 10, 2043-2054DOI ID2_HUMAN,Q02363 Experimental & Molecular Medicine 2019. volume 51, Article number: 80.
Apr 14, 2023•29 min
Immunoepigenetics 54. Macrophages, T lymphocytes and neutrophils each comply with epigenetic alterations to mediate the inflammatory response. DJGPhD.12April.2023.Authentic Biochemistry
References Guerra's notes
Apr 13, 2023•30 min
ImmunoEpigenetics 53.The metaphysics of biochemical control within epigenetic alteration of gene expression as obtained in macrophage mediated immune activation. DJGPhD.7April23'Authentic Biochem
References Dr Guerra's lecture notes-Immunology DJGPhD writings on Middle Platonist Metaphysics in Biochemistry: unpublished Curr Opin Biotechnol. 2020 Jun; 63: 111–117
Apr 07, 2023•30 min
ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast.
References Curr Opin Biotechnol. 2020 Jun; 63: 111–117 Epigenomics. 2019. VOL. 11, NO. 68 May Front.Genet., 23 October 2018 Sec. Epigenomics and Epigenetics Volume 9.
Apr 05, 2023•30 min
ImmunoEpigenetics 51. The Glutamine contribution to tumor bioenergetics and lipogenesis and the role of storage TAG in macrophage pro-inflammation. DJGPhD. 29.3.23
References Nature Communications 2020.volume 11, Article number: 4107. Nutrire 2016. volume 41, Article number: 14
Mar 30, 2023•28 min
ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD
References Cell 2012 148DOI: (10.1016/j.cell.2012.01.031) Biotechnology Journal 2016. Volume11, Issue1 Special Issue: Biotech Methods and Advances: 71-79. Molecular Cancer. 2020. volume 19, Article number: 39.
Mar 25, 2023•30 min
ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD
References Dr Guerra's lectures and spontaneous expectorations. Molecular Cancer 2020. volume 19, Article number: 39
Mar 23, 2023•30 min
ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23
References Methods Enzymol. 2009; 457: 425–450 Endocrinology , Volume 155, Issue 5, 1 May 2014, Pages 1653–1666 Am J Physiol Endocrinol Metab. 2008 Dec; 295(6): E1287–E1297
Mar 21, 2023•30 min
Immunoepigenetics 47. Intermediary metabolism re-enters the discussion on tumor corruption of cell division via diversion of glucose to NADPH production.DJGPhD
References Dr Guerra's lectures AJP Endocrinology and Metabolism. 2008. 295(6):E1287-97 Biochem Biophys Res Commun.1996 May 15;222(2):287-91 Carcinogenesis.2020 Jun; 41(4): 405–416 Oncogenesis 2017. volume 6, page e329.
Mar 18, 2023•30 min
ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23
References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
Mar 16, 2023•29 min
ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association.
References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
Mar 12, 2023•30 min
ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry.
References Antioxidants (Basel). 2023 Feb; 12(2): 274 J Lipid Res. 2016 May; 57(5): 868–881. J Biol Chem. 2007 Jan 12;282(2):1384-96. J. Am. Chem. Soc. 2014, 136, 36, 12624–12630
Mar 09, 2023•30 min
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