Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

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Episodes

BioMedical Portrait V. c7. NETs and the combined activities of elastase,NOX2,MPO and IP3 PTEN phosphatase potentiate inflammation-linked pathologies of lung and pancreas. DJGPhD.31.10.23 and

References J Zhejiang Univ Sci B. 2022 Jul 15; 23(7): 607–612 Biomaterials. 2020 Apr; 238: 119836. Int J Nanomedicine . 2023;18:5265-5287 Child Ballad 100. 1775. Pentangle. 1972.Willie O' Winsbury https://youtu.be/nwqP_yoszCE?si=C0NH51euOOTlPYn9

Nov 01, 2023•30 min

BioMedical Portrait V C.6 P. gingivalis Two Component System assembly and activation mediate infection court involvement in subsequent host vector pathology.DJGPhD. 30.10.23b.

References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2):S135–S139. J Oral Microbiol. 2017; 9(1): 1400858

Oct 30, 2023•30 min

BioMedical Portrait Vc4 Two component signal system pathogenic bacterial responses to host immunity and the gigipain cysteine protease opposing serum secretory IgA mediated phagocyte activation.DJGPhD

References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2): S135–S139. J Oral Microbiol. 2017; 9(1): 1400858. J Dent Res. 2020 Jun;99(6):644-649. Mozart WA 1782. D major, K. 385. Symphony 35 (Haffner)

Oct 29, 2023•30 min

BioMedical Portrait V.c3. The categorical analysis of Neutrophil involvement in multiple pathophysiologies requires cellular signaling to derivatize pleiotropic disease ontologies. DJGPhD.26.10.23

References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Gut Microbes. 2022; 14(1): 2073785. Adv Exp Med Biol. 2020:1263:13-23 Bredon, Anne. 1950. Led Zepplin. 1969. https://youtu.be/dZitPJMh60A?si=MnEpM-iemNFWEKE7

Oct 27, 2023•30 min

BioMedical Portrait V. The neutrohil oxidative burst and the roles of Phox generating superoxide and peptide arginine deiminase in phagocyte defense against pathogens and contrarion disease promotion.

References Blood (2004) 103 (11): 3993–3994 Anticancer Agents Med Chem. 2023;23(3):256-265 Med Hypotheses. 2021 Jan:146:110466.

Oct 26, 2023•30 min

BioMedical Portrait V. Introductory alethic unfolding of neutrophil glycolysis associated hyperinflammatory restraint.

References Cell. 2021 Aug 19;184(17):4480-4494.e15 Sci Rep. 2019 Mar 5;9(1):3433 Med Hypotheses. 2021 Jan:146:110466. Hayward, J. 1967. Moody Blues. "Tuesday Afternoon" https://youtu.be/jmMPBQ4kYKk?si=X0UyZJFq2AAnKSvJ

Oct 24, 2023•30 min

Continuing dialectical event ontology of epistemological requirements for validation of biochemical research. DJGPhD.23.10.23. Authentic Biochemistry Podcast

Send an email to authenticbiochemistry@gmail.com with comments.

Oct 23, 2023•30 min

All reciprocity in not disinterested so phenomena must be in equilibrium. But phenomena at equilibrium are invisible so reciprocity must be uncertain. DJGPhD.22.10.23. Authentic Biochemistry

Vide supra.

Oct 23, 2023•30 min

BioMedical Portrait IV. Postcript DJGPhD. 21 October 2023. Authentic Biochemistry Podcast

References Cureus. 2022. 14(9): e29696.doi:10.7759/cureus.29696 NMR Biomed. 2021 Feb;34(2):e4448. NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Nutrients. 2023 May; 15(9): 2029. Mozart, WA. 1791 K 626 Requiem in d minor.

Oct 22, 2023•30 min

BioMedical Portrait IV. 13b. Magnetic Resonance Imaging as a non-invasive tool in Neurodegenerative Diseases. DJGPhD.19.10.23 Authentic Biochemistry.

References Mol Cell Neurosci. 2012 Jan; 49(1): 44–53 NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5092–5094.

Oct 19, 2023•30 min

BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast

References Brain. 2023 Sep 13:awad309. doi: 10.1093/brain/awad309 J Alzheimers Dis. 2016 Feb 26;52(1):43-50. Haydn, FJ. 1796. MISSA IN TEMPORE BELLI https://youtu.be/8_5tgmAwN-E?si=AYzyMMk47b2IUt0Y Send an email to Dr Guerra! authenticbiochemistry@gmail.com

Oct 18, 2023•30 min

BioMedica; Portrait IV Coda II.c12. Biochemical Concatenations-the spatiotemporal sequences of molecular-cellular events of FTD's from proteinopathies to signalling and antigen recognition. DJGPhD.

References Brain. 2023 Sep 13:awad309 McBroom, Amanda. 1970 "the Rose" httBps://youtu.be/cO59ITNCxzk?si=v-qx_2_mPq3zbCYH

Oct 17, 2023•30 min

BioMedical Portrait IV c11. FTLD-tau is correlated with microglial and astrocytic inflammation and subsequent neural degeneration. DJGPhD. 16.10.23 Authentic Biochemistry.

References Front. Immunol., 19 October 2022 Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309

Oct 17, 2023•30 min

BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast

References Schubert, F. 1820. Rosamunde Overture. https://youtu.be/3Pc_LUItWQI?si=ZB3bsrmz3ReiJQdi Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309.

Oct 16, 2023•30 min

BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23

Mol Cell Biol. 2012 Jan;32(1):126-38 Mutat Res. 2013 Jul-Sep;753(1):24-40 Molecular Neurobiology 2022. volume 59, pages 4223–4241

Oct 14, 2023•29 min

BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23.

References Molecular Neurobiology 2022. volume 59, pages 4223–4241 Hum Genet. 1994 Jan;93(1):67-73 Mol Cell Biol. 2012 Jan;32(1):126-38

Oct 12, 2023•30 min

BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry

References The EMBO Journal (2022)41:e109108 Acta Neuropathol. 2007 Sep;114(3):221-9 Acta Neuropathol.2013 Jul; 126(1): 51–57 Brain 2008. Volume 131, Issue 6, Pages 1416–1432 Lovin Spoonful 1968. "She's a Lady" https://youtu.be/xyFdzevDOHg?si=bLl8FZzfE2SffvO4

Oct 12, 2023•30 min

BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD

References Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74LR2JY The EMBO Journal (2022)41:e109108 PLoS ONE 2013. 8(6): e65646. doi:10.1371/journal.pone.0065646 Molecular Neurodegeneration 2022. volume 17,Article number: 73...

Oct 10, 2023•29 min

BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation

References Mozart, WA. 1791. Clarinet Concerto in A major , K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5 Small GTPases. 2014; 5: e28579 Acta Neuropathol. 2023; 145(6): 749–772 J Immunol. 2000 May 15;164(10):4991-5

Oct 10, 2023•30 min

BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.

References Mol Biol Cell. 2001 Sep; 12(9): 2711–2720. Small GTPases. 2014; 5: e28579. Cells. 2021 Jul 20;10(7):1831. J Investig Med. 2023 Feb;71(2):113-123

Oct 08, 2023•30 min

BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.

References Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC Acta Neuropathol. 2023 Jun;145(6):749-772 Signal Transduction and Targeted Therapy 2022. volume 7, Article number: 175 Cardiovascular Research 2007. 74: 526 – 536 J Investig Med. 2023 Feb;71(2):113-123

Oct 08, 2023•30 min

BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.

References Neurol Genet. 2018 Jan 18;4(1):e211. J Immunol (2003) 171 (2): 594–599. Acta Neuropathol. 2023; 145(6): 749–772.

Oct 05, 2023•30 min

BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.

References Neurology. 2020 Jul 7; 95(1): e46–e58 Acta Neuropathol. 2023; 145(6): 749–772.

Oct 05, 2023•30 min

BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD

References Curr Opin Pharmacol. 2021 Apr; 57: 107–116

Oct 02, 2023•30 min

BioMedical PortraitIII. c13b.Immune cell metabolic dialectical usurpation of architechtonic control over inflammation and cell fate obtained from senescence and obesity.-linked dyslipidaemia.DJGPhD.

References Pisendel Johann G. 1735. Violin Concerto in D major Jun P I.7 https://youtu.be/dvwhXXvFiNg?si=BUb-f5rBncgADinx Curr Opin Pharmacol. 2021 Apr; 57: 107–116

Oct 01, 2023•29 min

BioiMedical Portrait III. NLRP3 Inflammasome and senescence-associated heterochromatic foci in macrophages, Kuppfer Cells and Liver sinusoidal endothelial cells contibute to liver/adipose disease

References Telemann Georg P. 1765. Overture D Major, TWV 55:D18 | Tafelmusik https://youtu.be/8r-IFLtN9x4?si=T2hp65oGT--dTivY Leukemia 2020 volume 34, pages 75–86 Nat Cell Biol. 2019 Mar; 21(3): 397–407

Sep 30, 2023•29 min

BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD.

References Haydn, Michael. 1760. Salve Regina in G MH32. https://youtu.be/u_Xjo5KJ3mg?si=kmKaaBJMvUgs_blX Leukemia 2020. volume 34, pages 75–86 CELL 2006. Volume 126, Issue 3, Pages 503-514 Nat Cell Biol. 2019 Mar; 21(3): 397–407. Curr Opin Pharmacol. 2021 Apr; 57: 107–116.

Sep 28, 2023•30 min

BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD.

References Saint-Saens. C. 1886. Symphony 3 (avec orgue) OP.78 J Clin Invest. 2011 Dec 1; 121(12):4903–4915 Cell Metab. 2022 Dec 6; 34(12): 2036–2046.e8.

Sep 26, 2023•29 min

BioMedical Portrait III. c10. Ribosomal collision frequency is attenuated by ZAK and GCN2 via mutually exclusive signalling events, DJGPhD. 25.9.23. Authentic Biochemistry Podcast

References Cell. 2020 Jul 23; 182(2):404–416.e14. Curr Genet. 2021 Feb; 67(1): 19–26. RNA Biol. 2023; 20(1): 737–749. published online 13sept23

Sep 26, 2023•29 min

BioMedical Portrait III. c9. Amino acid deprivation-linked fall of polypeptide synthetic fidelity triggers downstream ribosomal stress response phenomena including kinase mediated cell fate sequalae.

References Cell. 2020 Jul 23; 182(2):404–416.e14. Nature Communications 2020. volume 11,3146 Curr Genet. 2021 Feb; 67(1):19–26

Sep 23, 2023•30 min

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