Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

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BioMedical Portrait VII.c.6 Lipoprotein Lipase regulation performs a critical role in lipid homeostasis as evidenced by chylomicron clearance resistance in obese dyslipidaemic adolescents and adults.

References Nutrients. 2021 Jan 28;13(2):413 Nutrients. 2022 Jun 12;14(12):2438 J Diabetes Investig. 2023 Oct;14(10):1148-1156 Clinica Chimica Acta 2020. Volume 508, September Pages 61-68 Vivaldi. A. 1715. Gloria RV.589 https://youtu.be/XxwtYIKI9dE?si=ksQHEkQf5OlBpHCR

Dec 14, 2023•30 min

BPVII.c.5 Diminished circ.LPL and adiponectin in obese adolescents correlates with higher dyslipidaemic T2D, MetSynD, and insulin resistance via inflammation-triggering lipoprotein non-clearance.

References Nutrients. 2021 Feb; 13(2): 413. Advances in Clinical Chemistry Volume 64 , 2014, Pages 117-177. Front Physiol. 2020; 11: 796. Int J Mol Sci. 2023 Sep; 24(18): 13942. J Diabetes Investig. 2023. Oct;14(10):1148-1156. Nutrients. 2022 Jun 12;14(12):2438 RNA Biol. 2023; 20(1): 737–749. Clinica Chimica Acta Volume 508, Pages 61-68 Kirwan, Danny. 1971. "Sands of Time" Fleetwood Mac Lp Future Games https://youtu.be/1Jkp34jMeEw?si=fRzdAiA525bHRX5k...

Dec 12, 2023•30 min

BioMedical Portrait VII. C.4 Chylomicron associated endothelial luminal LPL differential interaction with ANGTPL isoforms reults in unique TRL disposition. DJGPhD.10Dec23

References J Diabetes Investig. 2023Oct;14(10):1148-1156 J Pediatr. 2021 Apr; 231: 200–206.e1. Front Physiol. 2020; 11: 796. ClinicaChimicaActa.2020 Volume 508, September Pages 61-68 Mozart,WA. 1787. Eine kleine nachtmusik K.525 https://youtu.be/nPbxIT9W1AY?si=mgzBQzpvuFzsVNtB

Dec 11, 2023•30 min

BioMedical Portarit VII. c.3. Introduction to chylomicron apoB48 and the angiopoietin-like LPL inhibitor contributions to circulating TAG. DJGPhD.9DEC23. authentic Biochemistry

References Am J Physiol Endocrinol Metab. 2021 Oct 1; 321(4): E493–E508. Clinica Chimica Acta Volume 508, September Pages 61-68 Advances in Clinical Chemistry Volume 64, Pages 117-177 Pancreas. 2017 Aug; 46(7): 874–879 Mozart WA 1775 Violin Concerto in G major, K. 216 https://youtu.be/j7Z6gouAVCc?si=X-3AnGtJoVvf7aF9

Dec 09, 2023•30 min

BioMed Portrait VII. c.2 Lipoprotein lipase mediated TAG delivery and adolescent obesity. DJGPhD.6Dec23. Authentic Biochemistry

References Clin Chim Acta . 2020 Sep:508:61-68 Applied Physiology, Nutrition, and Metabolism .2021. Volume 46, Numbe r 8.

Dec 07, 2023•30 min

BioMedical Portrait VII. Lipoprotein Lipase Pathobiochemistry. Prolegomena. DJGPhD. 5Dec23 Authentic Biochemistry

References J Diabetes Investig.2019 Nov; 10(6): 1430–1437.

Dec 06, 2023•30 min

Bio Med Portrait. c.16. NK cells promote the inflammatory court in NAFLD via mutations in lipid metabolism and excessive GK mediated glycolysis and lipogenesis in hepatocytes DJGPhD.3Dec23b

References Front. Immunol., 21 August 2019 Sec. Cancer Immunity and Immunotherapy Volume 10 Front Immunol. 2021; 12: 640869 PLoS One. 2014; 9(2): e87523 Vivaldi, A. 1719. "L 'inverno". https://youtu.be/pCqO-0339k0?si=k5xtuT8x7SfJeLok

Dec 04, 2023•30 min

BioMed Portrait VI.C.15 Characterization of four lipid and glucose metabolic polypeptides linked to obesity/T2D and NASH-->HCC.DJGPhD.3Dec23.Authentic Biochemistry Podcast

References Guerra-intermediary metabolic lecture archives ProcNatl Acad Sci U S A. 2014 Jun 17; 111(24): 8913–8918 Nutrition, Metabolism and Cardiovascular Diseases, 2023-09-01, Volume 33, Issue 9, Pages 1785-1796. Int J Cancer. 2019 Feb 1;144(3):533-544

Dec 03, 2023•30 min

BioMedical PortraitVI.C.14.Liver NK cell chemokine recruitment and the significant role of obesity in possible immunotoxicity in HCC ontogeny.DJGPhD.30.11.23

References Journal of Hepatology 2012 56, 704-713DOI Eur J Immunol. 2019 Jan;49(1):38-41 Front Immunol. 2016; 7: 19. Immun Ageing. 2020; 17: 16. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24): 8913–8918. Cells. 2021 Jun; 10(6): 1332...

Dec 01, 2023•30 min

BioMedical PortraitVI.c.13. Senescense and the aging of cells within systems apprehends the event ontologies of the stress phenomena-immune surveillance axis.DJGPhD.29.11.23. Authentic Biochemistry.

References Annual Review of Pathological Mechanisms of Disease 2010. 5:99-118. Immun Ageing. 2020; 17: 16 Williams, Hank.1949. ISLICC. https://youtu.be/4WXYjm74WFI?si=mhYowh4ClIOKmgVX

Nov 30, 2023•30 min

BioMedical Portrait VI. c.12. Obesity and viral infection-associated NK malfunction may lead to NASH and subsequent HCC. DJGPhD.28.11.23. Authentic Biochemistry

References Ann. Review of Pathological Mechanisms of Disease2010.5:99-118. Nature 2013 Jul 4;499(7456):97-101. Front Immunol. 2018; 9: 476 Cells. 2021 Jun; 10(6): 1332 Nat Rev Gastroenterol Hepatol (2023). https://doi.org/10.1038/s41575-023-00846-4

Nov 29, 2023•30 min

BioMedical Portrait VI. c.11 NK cell involvement in HepatoCellular Carcinoma. DJGPhD. 26.11.23. Authentic Biochemistry

References Front Immunol. 2018; 9: 476 Nature Reviews Gastroenterology & Hepatology 2023. 20 : 662–678 (2023) Cells. 2021 Jun; 10(6): 1332. Traffic, (Traditional. arr. S Winwood )1970. "John Barleycorn Must Die" https://youtu.be/icyPFsIcAV0?si=XSVxsiojZBrwGPx6...

Nov 27, 2023•30 min

"The Universe by Negation" DJGPhD.23.11.23

References Dr Guerra's Metaphysics notes Schubert, F. 1828. Quintet in C. Major D.956 https://youtu.be/Dc3iX7x73JY?si=j4jlU4ra_488pAuE

Nov 24, 2023•28 min

BioMedical Portrait VI.c.10.Alterations in the cytotoxic immune response can be dissociated from inflammation via intermediary metabolic mutation.DJGPhD.22.11.23. Authentic Biochemistry Pootdcast.

References Front Immunol. 2023; 14: 1151166. Dr Guerra: Biochemistry lecture archives Telemann, G.P. 1725.Viola Concerto in G major https://youtu.be/yMpzPMkrALM?si=lpyDYITx63jTc6-K

Nov 23, 2023•30 min

BioMedical PortraitVI.c.9 HLH mutations obtain complex NKvs.CD8+ T cell alterations in cytototoxicity and proliferation.DJGPhD.21.11.23 Authentic Biochemistry.

References Immunobiology. 2019 Jan; 224(1): 94–101 Front. Immunol., 14 June 2023 Cell. 2003 Nov 14;115(4):461-73 VonBingen.H. Born 1098AD https://youtu.be/yyAQc0kPZpU?si=y26mnCOmFpRis63_

Nov 22, 2023•30 min

BioMedical Portrait VI.c.8.The cytotoxicity of the NK cell Is a function of its bioenergetics. Glycolysis/OXPHOS vs. FAO/OXPHOS during activation/proliferation

References Front Immunol. 2023; 14: 1151166. Inflammation Research :official journal of the European Histamine Research Society 2018.1420-908X, Vol. 67, Issue 10. J Cell Sci. 2011 Dec 15; 124(24): 4147–4159. Hunter, R. and J. Garcia 1970. "Sugaree" https://music.youtube.com/watch?v=sxF9UJ-Rm0E&si=S4F0LvlFvUsTE1OO

Nov 21, 2023•30 min

BioMedical PortraitVI.C.7 IEI/IEM pathobiochemistry involves bioenergetics, transcriptional , translational, and post-translational modification sequalae.DJGPhD.19.11.23 Authentic Biochemistry.

References Front Immunol. 2022; 13: 950536. Inflamm Res. 2018 Oct;67(10):813-828 Mol Biol Rep. 2023; 50(8): 6963–6974. Front Immunol. 2023; 14: 1151166 Dr Guerra: Graduate biochemistry lecture archive Schubert.F . 1827.December.Impromptu #3 in G flat major performed by Khatia Buniatishvili https://youtu.be/LUp2u9wI1fY?si=hhiUmiyXyQ78Qtaw and "Questions" Manfred Mann 1976. https://youtu.be/qvvstrKLvts?si=-I8bGmB2oC3FpPLw...

Nov 19, 2023•30 min

BioMedical Portrait VI c.6.Hemophagocytic lymphohistiocytosis ACAD9/Rab27A/+/- FBase1 mutations linked to NK and CTL immunodeficiences.DJGPhD. 16/11/23. Authentic Biochemistry.

References Front Immunol. 2023; 14: 1151166. Int J Mol Sci. 2019 Jan; 20(2): 443.

Nov 17, 2023•30 min

BioMed Portrait VIc.5. NK cell Inborn Error Of Immunity links to failed fatty acyl CoA dehydrogenase-obtained immunodeficiency.DJGPhD. 15.11.23. Authentic Biochemistry

References Front Immunol. 2023; 14: 1151166

Nov 16, 2023•30 min

BioMedical Portrait VI.c4. Tumor and DC antigen VAX directed melanoma therapy reveals CD8+CTL and NK cell surface population dynamics.DJGPhG.14.11.23. Authentic Biochemistry.

References Cancers 2020, 12 (4),952 JBC. 2018. 293: 2422-2437. J Immunother Cancer. 2021 Nov;9(11):e003675 Front Oncol. 2023 May 18:13:1145667 Front. Immunol.2019. Sec. Cancer Immunity and Immunotherapy Volume 10 Int. J. Mol. Sci. 2019, 20(3), 646 Front Immunol. 2019; 10: 14 Vivaldi, A. 1716. RV589 Gloria https://youtu.be/2eWjQOdYzMQ?si=dpZaNZilqPXi6fJU

Nov 15, 2023•30 min

BioMedical PortraitVIc.3. NK cell phenotypic variation is tighly regulated to facillitate unique immune sequalae including tumor ablation, pathogen elimination and autoimmunity.13.11.23.DJGPhD

References Immunity. 2018 Oct 16;49(4):695-708 Front Immunol. 2019; 10: 14 Front. Immunol., 24 July 2017 Vol 8. Sec. T Cell Biology

Nov 14, 2023•30 min

BioMedical ortrait VI. Development of a dendritic cell antigen presenting melanoma kinase derived vax targeting NK cells to ablate malignancy.DJGPhD.11NOV23

References Front Immunol. 2019; 10: 14 Cancer Immunol Immunother. 2016 Apr;65(4):441-52 Anal Cell Pathol (Amst).2018; 2018: 787.1814. Molecular Cancer 2020. volume 19, Article number: 39 Cohan, G. 1917. "Over There" https://youtu.be/BYV044H5muI?si=LdANMG6dtXeC14tj

Nov 12, 2023•30 min

BioMedical Potrait VI. Natural Killer Cells: opening remarks. DJGPhD.9NOV23. Authentic Biochemistry

References Anal Cell Pathol (Amst).2018; 2018: 787.1814 Zeno (the Eleatic) 5thCentury B.C. Magna Graecia, Italian Penn. Student of Parmenides Guerra-basic immunology lectures Schubert,F. 1826. String Quartet No. 15 in G major , D. 887. https://youtu.be/xW8PI2Xa8eA?si=smnLmSKamUP34qon

Nov 09, 2023•30 min

BioMedical Portrait V. Coda c.13 Small molecule pyrazolo-oxazepine derivitive mediated PFK-1 activation depletes NADPH dependent neutrophil oxidative burst. DJGPhD.07NOV23. Authentic Biochemistry

References Cell 2021. 184, 1–15 ⁠J Zhejiang Univ Sci B.⁠ 2022 Jul 15; 23(7): 607–612.

Nov 08, 2023•30 min

BioMedical Portrait V.c.12. Is there a compositional-sequential event ontology linking "moonlighting"c-Fos with NOX2 PX domain PIP3 binding?DJGPhD. 6NOV23

References Nature Communications 2019. volume 10, Article number: 1528 Adv Exp Med Biol. 2019:1111:1-17. doi10.1007/5584_2018_185. Nature Immunology volume 20, pages559–570 (2019) Biochem J. 2001 Dec 15; 360(Pt 3): 513–530. PNAS 1993. 90: 10952-10956

Nov 06, 2023•30 min

BioMedical Portrait V.c.11 The Phosphoglycerolipid metabolome that orchestrates membrane topology and surface chemistry that supports necessary protein association for neutrophil immunoresponses.

References Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids2014.Volume 1841, Issue 9, Pages 1241-1246 Guerra-graduate lipid lectures

Nov 05, 2023•30 min

BioMedical Portrait V.c.10. Phosphphatidyl inositols and phagosmal genesis in activated neutrophils upon pathogen infection.

References J Adv Res. 2018 May; 11: 33–41. Immunol Rev. 2023. Volume314, Issue1 . Special Issue: Neutrophils and Friends .March 2023. Pages 158-180. Biochim Biophys Acta Biomembr.. 2023 Oct;1865(7):184180 Front Cell Dev Biol. 2022; 10: 945749. Tchaikovsky, PI., 1878. Violin Concerto in D major, Opus 35 ( TH 59 ; ČW 54). https://youtu.be/2ckqOukGKK8?si=jl9TYFA2pgvtI8um...

Nov 05, 2023•30 min

BioMedical PortraitV.c9. Both glycolytic and OPP regulation combine complex allosteric and amphibolic sequalae that may converge on an immune- hyperinflammatory state. DJGPhD.2NOV23.

References Guerra 2023-graduate biochemistry lecture canon and marginalia Mol Oral Microbiol. 2019 Apr; 34(2): 27–38. Front Cell Dev Biol. 2022; 10: 945749. Mozart, WA. 1784. Piano Concerto No. 17 in G major, KV. 453 https://youtu.be/iYNbMclI5Ls?si=_P9oK14c_wb98VXG...

Nov 02, 2023•30 min

BioMedical Portrait V.c8. NOX2 subunitorganization, oxygen availability and phase I discussion of glycolytic allosteric control.DJGPhD.01Nov23

References FASEB 2017. Volume 31, Issue2 Pages 663-673 Guerra,DJ. Graduate Biochemistry Lectures Albioni , Thomaseo. 1708. Sonate da chiesa ("op. 4") (for violin and basso continuo), https://youtu.be/IMmjjcfG2c4?si=C4VG-rPWL_Fv7-Xe

Nov 01, 2023•30 min

BioMedical Portrait V C.5 Periodontitis-linked CVD. DJGPhD. 30.10.31

References Eur J Microbiol Immunol (Bp). 2011 Mar;1(1): 41–58 J Periodontal Res. 2018 Jun; 53(3):403–413. DJGPhD lecture notes

Nov 01, 2023•30 min

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