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Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com
Science
Natural Sciences
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Episodes

BioMedical Portrait VIII. c.21 Lysopholpids like sphingolipids hydrogen bond to cholesterol mediating lipid membrane raft mobility. DJGPhD. 2Feb2024. Authentic Biochemistry Podcast

References Biochimica et Biophysica Acta (BBA) - Biomembranes 2015. Volume 1848, Issue 3 , Pages 805-812 Soft Matter 21-Jan-2021 Am J Rhinol Allergy. 2015 Jan-Feb; 29(1): 35–40. Scientific Reports 2017. volume 7 , Article number: 39661. Antioxid Redox Signal. 2011 Aug 15;15(4): 1043–1083. Journal of Immunotoxicology. 2008. 5:4, 347-352 Mozart, W. A. 1773, October.Symphony No. 25 in G minor K.183. https://youtu.be/707oHEGF6l8?si=J_WI-BhX0cvI9caQ Jon Anderson , Chris Squire , Bill Bruford , and St...

Feb 03, 2024•29 min

BioMed PortraitVIII.c.19. Membrane thermotropic phase transition enthalpic responses to Leukotriene synthesis in relation to cholesterol and lysophospholipid fluid dynamics.DJGPhD.31.1.24.Authentic BC

References Dr Guerra: membrane lectures Balin, M.1966. "Coming Back to Me" Jefferson Airplane. Surrealistic Pillow.1967. https://youtu.be/y2f3tlgApHw?si=cTa1nhYw6kcycxUs Dylan (Zimmerman),R. 1962 "Girl from the North Country". w. Johnny Cash. https://youtu.be/Je4Eg77YSSA?si=eYXfJhwOQisGjPHW Schubert, F. 1828.Piano Sonata in B-flat major, D.960 https://youtu.be/lncNcNtGkJY?si=KRTh3hQStQ3x51Ug

Jan 31, 2024•30 min

BioMed Portrait VIII.c.18Aspirin PGS (COX) inhibited membrane topological and integrated molecular dynamics: leukotriene –cytokine mediated asthmatic inflammation.DJGPhD.29.1.24. Authentic Biochem.

References Biochimica et Biophysica Acta (BBA) - Biomembranes 2015. Volume 1848, Issue 3 . Pages 805-812. J Immunol. 2018 Feb 1; 200(3): 915–927. Am J Rhinol Allergy. 2015 Jan-Feb; 29(1): 35–40. Corelli,A. 1714. Concerto in D Major Op. 6 No. 4, https://youtu.be/3smZkpqXYHs?si=uwEdDkRv-bz-zJXW...

Jan 29, 2024•30 min

BioMed Portrait VIII. c.16. Coordinated complimentarity of cell cycle MEK kinase cascade with the IL33-ST2 and CysLT1R mediatedILC2 activation to promote type 2 immunopathology. DJGPhD.25.1.24

References J Immunol. 2018 Feb 1; 200(3): 915–927 Cells. 2020 Jan; 9(1): 198. Cells. 2022 Apr; 11(7): 1105 Nature Comm. 2020. volume 11, Article number: 35 Schubert F. 1829. Fantasie in F minor. D940 https://youtu.be/UyjzqPPXDcw?si=XW_SMP7j-Kza8pmq Winwood, Capaldi and Wood. 1967 (Traffic). "Dear Mr Fantasy" https://youtu.be/dyMiUmrouZU?si=1ZSdXupm3WFBAxTz...

Jan 26, 2024•30 min

BioMedical Portrait VIII.c.14 The dialectical events between immune responses and leukotriene signaling are modulated by tissue-resident and circulating cell patterns via RNA binding proteins.DJGPhD.

References Nat Commun. 2022; 13: 4435. Virchows Archiv: European Journal of Pathology, 2020. Vol. 476, Issue 2 Cell Death Differ. 2015 Apr; 22(5): 703–718 Pentangle.1971. Hunting Song. https://youtu.be/CwvpMGc_J-w?si=s6pS2agc5s1N0H2z Falconieri , Cima, Uccellini, Turini, Merula, et al. 1600-1650. Early Italian Baroque Ensemble. https://music.youtube.com/playlist?list=OLAK5uy_mQznM05seareQTK-s3j-1VgS4DHblD5po&si=3mJts6TW3-T2g7k5...

Jan 22, 2024•30 min

BioMedical PortraitVIII.c.13 Leukotriene metabolism and reception is linked to innate like lymphocytes involved in airway inflammation and hyper-responsiveness-associated asthma.DJGPhD.19.1.24.AB.

References J Immunol. 2009 Feb 1; 182(3): 1641–1647. Cell Reports 2015 10, 2043-2054DOI Virchows Archiv:European Journal of Pathology. 2020. 09456317, Vol. 476, Issue 2 Poe, EA. 1845. "the Raven" https://youtu.be/wAdQ3CcPHQU?si=2qpStYF2gdUJ4f35 Buddy Morrow and his Orchestra. 1960. "the Black Cat" https://youtu.be/9w_VL7oq-mE?si=XiorgTkvSGzJ4BK0

Jan 20, 2024•30 min

BioMedical Portrait VIII.c.12. 5-LOX associates with FLAP and PLA2 at the nuclear envelope to trigger and control ILC2 mediation of the allergic asthma AHR pathology. DJGPhD 17.1.24. Authentic Bioch.

References Immunology. 2019 Apr; 156(4): 402–412. J Immunol. 2017 Aug 1; 199(3): 1096–1104 Front. Immunol., 06 June 2019 Mol Biol Cell. 2012 Nov 15; 23(22):4456–4464. Virchows Archiv: European Journal of Pathology, 09456317, Feb2020, Vol. 476, Issue 2 Pavana, Gagliarda, Ciaccona, Passacaglia 1535-1615. https://youtu.be/AY533zpCw74?si=224HuGs438aPHrrd

Jan 18, 2024•30 min

BioMedical Portrait VIII. c.10. The LOX5 and LOX12/15 pathways for 20:4, 20:5 and 22:6produce over 50 unique molecular species of oxylipins and lipoxins with unique biological sequalae.DJGPhD.14.1.24.

References Int.J. Mol. Sci. 2022, 23(23), 14883. Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726. British J of Pharmacology. 2015. Volume172, Issue17. 4319-4330 Mozart, WA. 1791. Requiem.D Minor, K. 626 https://music.youtube.com/watch?v=RDegrbjfiWU&si=x-SSYDxEOv5Vc4xE Miller, S. 1977. Wintertime. https://youtu.be/HUv7pXgZ9NA?si=JzaZOWKLkPEMiyKj...

Jan 15, 2024•30 min

BioMedical Portrait vIII. Leukotrienes. c.8 Leukotriene regulated Heterodimer Nuclear Receptor transcription factors organize around complex multi-ligand binding and sojourner molecular modifiers

References British J of Pharmacology 2015. Volume172, Issue17 September Pages 4319-4330 Chem Rev. 2011 Oct 12; 111(10): 6321–6340 JBiol Chem. 2020 Jul 17; 295(29): 10045–10061 Mozart, WA. 1768. January. Symphony #7 in D major K.45.composed in Vienna just 10 days before he turned 12 years old. https://youtu.be/ABOle_eSq9c?si=GcA8EvXbpEZP0W0A

Jan 10, 2024•29 min

BioMedical Portrait VIII.c.6 Precursor 20:4 5,8,11,14 derived prostaglandins and leukotriene roles in PPAR and RXR transcription factor expression in mammalian reproductive tissues. DJGPhD. 04JAN24.AB

References General and Comparative Endocrinology 2018-06-01, Volume 262, Pages 27-35. Immunohorizons. 2022 Jun 22; 6(6): 366–372. Biochem J. 2009 Dec 14;425(1):265-74. Nature. 2023; 614(7948): 530–538. Winwood,S. 1969 Blind Faith "Had to Cry Today". https://youtu.be/Z4Yo_VbGdMg?si=3whbMcoWNFtfgPwE

Jan 04, 2024•30 min

BioMedical Portrait VIII.c.3. Leukotriene molecular speciation involves subcellular re-distribution of modifying enzymes and adaptor proteins associating with ER and Nuclear membranes.DJGPhD.28.12.23

References Infect Immun. 2021 Aug; 89(8): e00095-21. Eur J Immunol. 1992 Oct;22(10):2705-11 Progress in Lipid Researc 2015. h Volume 57 , January Pages 13-39 Am J Physiol. 1999 Apr;276(4):C988-94. Beethoven, L. 1813, 08 December.: Symphony no. 7 in A major, op. 92. https://youtu.be/T7CjuvE8oFA?si=il248jF2v7njd-Jo...

Dec 29, 2023•30 min

Dyslipiaemia Coda III. The proposed use of apolipoprotein serum concentration and hyperTAG may require a deeper analysis at the transcriptomic and proteomic levels. DJGPhD.20.12.23 Authentic Biochem.

References Biomolecules 2021, 11(7), 1016 Journal of Clinical Lipidology Volume 16, Issue 4, July–August Pages 472-482 Lennon-McCartney 1964. If I Fell https://youtu.be/F_80s6S_7Vw?si=PmlyAATePHfqmzqv Lennon-McCartney. 1963. Misery.https://youtu.be/qhbcN3ew9z0?si=DvePBioaAgZ7_dRW Alexander. A. 1962. Anna. Cover by the Beatles. https://youtu.be/b3zNKWyLfus?si=kEaNqNy_JF_HZNji

Dec 21, 2023•30 min
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