The Substance is a bloody, campy, fiercely feminist body horror film. Demi Moore plays a TV aerobics instructor who learns of a mysterious drug that causes another younger, entirely separate version of herself (Margaret Qualley) to splurt out of her back and assume her consciousness. The movie has earned Moore her first Oscar nomination, and she's the frontrunner in this year's best actress race. So we thought it would be the perfect time to revisit our conversation about the movie.