Send us a text What if your biomanufacturing facility could run itself, optimize its own processes, and operate non-stop? This isn't science fiction – it's the cutting-edge reality Professor Massimo Morbidelli is helping to create. In this captivating episode, the bioprocessing pioneer unveils how AI, continuous manufacturing, and revolutionary machine learning techniques are transforming the industry landscape. As a Professor Emeritus at ETH Zurich and Politecnico di Milano, and a co-...
Sep 05, 2024•23 min•Ep 86•Transcript available on Metacast Send us a text Imagine a world where biologic drugs are produced faster, cheaper, and with unprecedented precision. In this episode, we dive into that future with Professor Massimo Morbidelli, a trailblazer in bioprocessing innovation. As a Professor Emeritus at ETH Zurich and Politecnico di Milano, and a co-founder of ChromaCon (now YMC) and DataHow, Massimo Morbidelli has been at the forefront of bioprocess innovation. He is currently the recipient of the ERC Advanced Grant Continuous Digitali...
Sep 03, 2024•24 min•Ep 85•Transcript available on Metacast Send us a text Are your shake flasks holding back your bioprocess development? Discover how to transform them into smart bioreactors! In this game-changing episode, we talk with Jens Bayer about the groundbreaking DOTS platform. He is a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientific Bioprocessing. Jens reveals how this cutting-edge technology is bridging the gap between simple shake flasks and complex bioreactors, offering scien...
Aug 29, 2024•23 min•Ep 84•Transcript available on Metacast Send us a text Are shake flasks outdated relics or untapped goldmines of bioprocess development? In this eye-opening episode, we dive deep with Jens Bayer, a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientific Bioprocessing. Jens shatters common misconceptions about shake flasks, revealing why they remain indispensable tools in both industry and research settings. Discover: Why shake flasks are irreplaceable for rapid, cost-effective...
Aug 27, 2024•18 min•Transcript available on Metacast Send us a text Dive into the cutting-edge world of autologous cell-based therapy with Deana Mohr, CEO and co-founder of MUVON Therapeutics, spin-off from the University of Zurich. In this eye-opening episode, discover how MUVON Therapeutics’ innovative approach to muscle regeneration is revolutionizing treatments for stress urinary incontinence and beyond. Learn how her team is tackling the challenges of bringing personalized medicine to market at scale, from navigating complex regulations to au...
Aug 22, 2024•18 min•Transcript available on Metacast Send us a text Discover how scientists are transforming lives through innovative muscle regeneration therapy. In this captivating episode, Deana Mohr, CEO and co-founder of MUVON Therapeutics, spin-off from the University of Zurich, unveils her groundbreaking autologous muscle regeneration technology for treating stress urinary incontinence. Learn how this minimally invasive treatment harnesses the power of a patient's own cells to restore muscle function, offering hope to millions. Diana s...
Aug 20, 2024•23 min•Transcript available on Metacast Send us a text Ever wondered why some biotech facilities thrive while others struggle Alfredo Martínez Mogarra, a Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets to successful biotech manufacturing. In this eye-opening episode, Alfredo shares critical insights on bridging the gap between lab-scale processes and industrial production. You will get: Strategies for seamless scale-up and risk mitigation in bioprocess development T...
Aug 15, 2024•20 min•Transcript available on Metacast Send us a text Ever wondered what it takes to build a large-scale biotech manufacturing facility? Alfredo Martínez Mogarra, a seasoned Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets behind successful biotech facility design and scale-up. He has been at the forefront of transforming bench processes into industrial realities. In this eye-opening episode, Alfredo shares critical insights on navigating the complex world of biotec...
Aug 13, 2024•24 min•Transcript available on Metacast Send us a text Unlock the secrets of cell factories and discover how cutting-edge technologies are revolutionizing biopharmaceutical production. In this episode, we welcome Mauro Torres, a postdoctoral researcher at the University of Manchester, who takes us on a fascinating journey through the complex world of protein manufacturing. Mauro Torres explains the intricate steps involved in the secretory pathway, from gene expression to protein export, likening it to a sophisticated car manufacturin...
Aug 08, 2024•18 min•Ep 78•Transcript available on Metacast Send us a text Unlock the secrets of cell factories with Mauro Torres, a postdoctoral researcher at the University of Manchester who brings cutting-edge insights into protein production. Discover how the concept of cell factories has evolved from basic insulin extraction to groundbreaking treatments for genetic disorders and cancer. We reveal the challenges faced by biotech scientists in bioprocess development and offers a fascinating analogy between car manufacturing and cellular protein assemb...
Aug 06, 2024•23 min•Transcript available on Metacast Send us a text Curious about the latest innovations in cell analysis technology? Join us in this episode with Furkan Gökçe, New Business Development Manager at Amphasys, as we delve into the fascinating world of Impedance Flow Cytometry (IFC). Furkan shares how IFC is revolutionizing single-cell analysis by providing faster, more precise, and high-resolution data. Key Takeaways: Real-Time Precision: Discover how IFC allows for real-time, label-free assessments of cells, providing detailed insigh...
Aug 01, 2024•23 min•Transcript available on Metacast Send us a text Ever wondered how single-cell analysis could revolutionize bioprocessing? Join us in this episode as we delve into the cutting-edge world of impedance flow cytometry. Furkan Gökçe, New Business Development Manager at Amphasys, shares his insights on the transformative power of this technology in the biotech industry. With a background in engineering and physics, Furkan provides a unique perspective on tackling the complexities of biological systems. Key Takeaways: Enhanced Process...
Jul 30, 2024•17 min•Transcript available on Metacast Send us a text Dive into the transformative world of bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech, where high-throughput screening meets cutting-edge biotechnological advancements. Join us as we chat with Sebastian, a seasoned scientist and entrepreneur who has revolutionized the workflow of high-throughput screening of titer, glycosylation, and aggregation with innovative bead-based assays. Key Takeaways: Streamlined Workflow: Learn how a simplified sample prep can...
Jul 25, 2024•17 min•Transcript available on Metacast Send us a text Ready to revolutionize your lab work? Join us as we dive deep into bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech. Discover how these tiny beads are making a massive impact on biotech research and development — for titer, glycan, and aggreation screening — and how this developability screening platform can enhance your antibody discovery, antibody engineering and lead optimization. In this episode, you’ll learn: Speed and Simplicity: How bead-based assa...
Jul 23, 2024•19 min•Transcript available on Metacast Send us a text How do small biotech companies make strategic decisions with limited resources? This episode dives deep into the art of prioritization and outsourcing to achieve success. Join us as we speak with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, a seasoned biotech scientist with years of experience in both large and small biotech companies. Mark shares his invaluable insights on navigating the complexities of bioprocess development and outsourcing. In this ...
Jul 18, 2024•22 min•Ep 72•Transcript available on Metacast Send us a text Are you navigating the complex world of bioprocess CMC development and manufacturing in a small biotech company? Our latest episode is a must-listen! Join us as we sit down with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, who shares invaluable insights on overcoming the unique challenges faced by small biotech firms. In this episode, we explore: The critical communication strategies needed for successful outsourcing to CDMOs. How small biotechs can le...
Jul 16, 2024•19 min•Ep 71•Transcript available on Metacast Send us a text In this insightful episode, we explore the cutting-edge field of glycoengineering and its transformative impact on biopharmaceutical drug design. Join us as we chat with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, to uncover the nuances of chemoenzymatic glycogen engineering and its potential to revolutionize therapeutics. Key Takeaways: Understanding Glycoengineering: Discover the three main approaches—genetic, metabolomic, and ch...
Jul 11, 2024•16 min•Transcript available on Metacast Send us a text Uncover the hidden science behind creating safer, more effective biological drugs! Dive into glycoanalytics and glycoengineering, the secret weapons revolutionizing biopharma. Join us as we talk with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, who breaks down the complexities of glycosylation and its pivotal role in drug development. Key Takeaways: Critical Quality Attributes: Understand how glycans influence the function and struc...
Jul 09, 2024•18 min•Transcript available on Metacast Send us a text Join us as we explore the pivotal role of process mapping in biotech knowledge management. Our guest, Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, shares invaluable insights into leveraging technology to streamline operations. Key Insights: Identifying Critical Process Knowledge: Learn strategies to identify and manage vital process knowledge essential for optimal performance. Transitioning from Implicit to Explicit K...
Jul 04, 2024•29 min•Transcript available on Metacast Send us a text Want to turn your biotech chaos into streamlined success? Learn from expert Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, on how process mapping can transform your knowledge management and elevate your business performance. Key Takeaways: Eliminate Scope Creep: Learn how to maintain focus in projects despite shifts and changes, improving productivity and reducing frustration. Bridge Experience Gaps: Understand how proc...
Jul 02, 2024•14 min•Transcript available on Metacast Send us a text Get ready to dive into the fascinating world of cryopreservation! In this episode, we welcome Mark Davison, an experienced entrepreneur and CEO of Grant Instruments, leaders in laboratory equipment, to explore the intricate science of freezing and thawing cells. Mark brings his wealth of experience to demystify this crucial process, revealing how cutting-edge technology ensures precision and reliability in preserving biological samples. Key Takeaways: Mastering Precision: Learn ho...
Jun 27, 2024•16 min•Ep 66•Transcript available on Metacast Send us a text Picture a world where we can freeze cells and bring them back to life perfectly intact. In this episode, we're joined by Mark Davison, a leading expert in cryopreservation and CEO of Grant Instruments to uncover the intricate science of freezing and thawing cells. From basic principles to advanced techniques, we delve into how cryopreservation is revolutionizing biotechnology and cell therapies. Key Takeaways: Cell Survival Secrets: Discover why water is both a friend and foe...
Jun 25, 2024•24 min•Transcript available on Metacast Send us a text Could sound waves be the revolutionary key to gene therapy manufacturing? In this episode, Gabriel Dumy, CTO and Co-founder at Kolibri, reveals how acoustic waves are set to transform cell harvesting and gene transfection processes, making biomanufacturing more efficient and less damaging to cells. Kolibri is a company revolutionizing the way we grow and engineer cells at scale using acoustic waves. Key Takeaways: Real-Time Cell Harvesting: Discover how reconfigurable acoustic wav...
Jun 20, 2024•22 min•Ep 64•Transcript available on Metacast Send us a text Are sound waves the key to revolutionizing gene therapy? In this groundbreaking episode, we sit down with Gabriel Dumy, CTO and Co-founder at Kolibri, a company revolutionizing the way we grow and engineer cells at scale using acoustic waves. Gabriel shares the challenges facing modern bioproduction and unveils an exciting solution that's setting the stage for the future of gene therapy. Key Takeaways: Enhanced Cell Productivity: Discover how acoustic waves minimize shear str...
Jun 18, 2024•25 min•Transcript available on Metacast Send us a text Dive into the future of bioprocessing with Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, as we explore how magnetic bead technology is transforming downstream processing. MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals. Key Takeaways: Streamlined Purification: Discover how magnetic beads enable simultaneous clarification and capture, boosting efficiency. Cost...
Jun 13, 2024•15 min•Ep 62•Transcript available on Metacast Send us a text Dive into the latest episode as we explore how magnetic bead technology is revolutionizing downstream processing, promising higher yields and greater purity. Our guest, Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, shares his insights on overcoming industry challenges and the future of purification. MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals. Key Takeawa...
Jun 11, 2024•19 min•Transcript available on Metacast Send us a text Unlock the future of epigenetics and join us for an insightful conversation with Jonathon Hill as he delves into the groundbreaking world of next-generation sequencing (NGS) and its transformative impact on science and medicine. Jonathon Hill is the VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Biology and Physiology at Brigham Young University. Discover how cutting-edge nanopore technology is overcoming the limitations of traditi...
Jun 06, 2024•21 min•Ep 60•Transcript available on Metacast Send us a text Curious about the latest advancements in next-generation sequencing (NGS) and how they are revolutionizing science and medicine? In this episode, we delve into the cutting-edge developments of NGS with our expert guest, Jonathon Hill, VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Biology and Physiology at Brigham Young University, who has been at the forefront of this transformative field. Key Takeaways: Discover how NGS is empowe...
Jun 04, 2024•17 min•Ep 59•Transcript available on Metacast Send us a text Dive into the realm of biotech with our latest episode as we unravel the enigma of Quality by Design (QbD) with Matthias Müllner, CEO of & Co-Founder bespark*bio, a company empowering viral vector-based medicines. Discover how integrating QbD principles early in your development cycle can revolutionize your approach to producing safe, high-quality products consistently. From understanding critical quality attributes to designing robust manufacturing processes, we illuminate th...
May 30, 2024•19 min•Ep 58•Transcript available on Metacast Send us a text Join us for an insightful episode as we dive into the world of bioprocess CMC development strategies with Matthias Müllner, CEO of & Co-Founder bespark*bio, a company empowering viral vector-based medicines. Matthias shares his wealth of knowledge on avoiding common pitfalls in developing robust Chemistry, Manufacturing, and Controls (CMC) strategies. He also emphasizes the critical elements that ensure your biotech product's success. Key Takeaways: Start Strong: Establis...
May 28, 2024•17 min•Ep 57•Transcript available on Metacast 
