with Jorge Conde (@jorgecondebio), David Reich, and Hanne Tidnam (@omnivorousread) Trying to reconstruct the deep past of ancient humans out of present-day people has until now been like trying to reconstruct a bomb explosion in a room from bits of shrapnel, says David Reich, Professor of Genetics at Harvard Medical School and author of the new book, Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past. But technological advances and new tools available only in the l...
Jul 13, 2018•32 min•Ep 392•Transcript available on Metacast with Ken Coleman, Ben Horowitz (@bhorowitz), and Michel Feaster (@michelfeaster) Everyone talks about the importance of mentorship in our professional development, whether it's networking to broaden career opportunities or learning from someone more experienced. But how does one break into an industry without established contacts or prior exposure? Are things different if mentors/mentees come from different backgrounds? If you're already more established in your career, how can you help up-and-c...
Jul 12, 2018•33 min•Ep 391•Transcript available on Metacast with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Steven Johnson (@stevenbjohnson) The rise of zero-sum thinking -- which has come snapping back recently -- slows and even halts progress, observes Marc Andreessen. Because you're then dividing up a smaller piece, adds Ben Horowitz, instead of growing the pie altogether. This is true not just in economics, politics, and tech, but also in business relationships (and life), too. And speaking of such relationships, how does the partnersh...
Jul 06, 2018•42 min•Ep 390•Transcript available on Metacast Compensation is a topic near and dear to everyone’s heart… but what does “compensation” fully mean — and what does it include, what doesn’t it include? How do entrepreneurs compete for talent in an intensely competitive environment, while balancing their startup’s affordability considerations? This wide-ranging episode of the a16z Podcast (based on an event held for entrepreneurs at Andreessen Horowitz earlier this year) covers all things compensation — from philosophical questions such as how t...
Jun 21, 2018•39 min•Ep 389•Transcript available on Metacast with Martin Fischer (@fischermartin), Saurabh Ladha (@ladhasaurabh), Chris Rippingham, and Hanne Tidnam (@omnivorousread) Continuing our series on how tech is changing construction -- one of the industries most resistant to change (and facing declining productivity) -- this episode of the a16z Podcast looks at what happens when you go from planning to actually putting boots on the ground. How can tech translate rich data sets into the just-right types, amounts, and levels of information for each...
Jun 14, 2018•37 min•Ep 388•Transcript available on Metacast with Greg Lynn (@greglynnform), Gina Neff (@ginasue), Tracy Young (@Tracy_Young), and Hanne Tidnam (@omnivorousread) Construction has been one of the industries most resistant to innovation and change over the last decades -- productivity has actually decreased there while it has risen in other industries around it. So how are new technologies (finally!) beginning to transform the most brick-and-mortar of all the (literally!) brick-and-mortar industries? This episode of the a16z Podcast -- with ...
Jun 13, 2018•33 min•Ep 387•Transcript available on Metacast There are over 20 million programmers out there -- and double that, if you count everyone else coding in other ways -- but where are the next 100 million developers? How do we get to a billion developers? The answer, observes a16z general partner Peter Levine in conversation with GitHub co-founder and former CEO Chris Wanstrath (based on a Q&A recorded at our last a16z Summit event) lies in changing the very definition of a "programmer" and "programming". It might even me...
Jun 08, 2018•19 min•Ep 386•Transcript available on Metacast Here's the hard thing about security: the more authentication factors you have, the more secure things are... but in practice, people won't use too many factors, because they want ease of use. There's clearly a tension between security and usability, not to mention between security and privacy (good security doesn't always come with great privacy -- what if you're a journalist or dissenter under a repressive regime??). And finally, there's a tension between the convenience and inconvenience of h...
Jun 06, 2018•34 min•Ep 385•Transcript available on Metacast with Gregory Allen (@Gregory_C_Allen), Gayle Lemmon (@gaylelemmon), Ryan Tseng, and Hanne Tidnam (@omnivorousread) We now live in a world where connecting the dots between intel and modeling threats has become infinitely more complex: not only is the surface area to protect larger than ever, but the entry points and issues are more diverse than ever. This conversation, with Gregory Allen, a Fellow at the Center for a New American Security and co-author of the Belfer Center report on AI and Natio...
May 25, 2018•29 min•Ep 384•Transcript available on Metacast The International Consortium of Investigative Journalists is the organization responsible for the compilation and release of the first the Panama Papers, a series of 11.5 million documents that detailed the offshore dealings of governments and individuals the world over, soon followed by the Paradise Papers. In this podcast, a16z general partner John O'Farrell interviews ICIJ director Gerard Ryle discuss how journalists manage, sort through and coordinate so much information and data to pull out...
May 23, 2018•24 min•Ep 383•Transcript available on Metacast When it comes to B2B2C business models -- which combine both business to business (B2B) and business to consumer (B2C) -- who really "owns" the customer? That question might not matter as much in more symbiotic, mutually beneficial marketplaces and other platform contexts, but can be a problem in other contexts or if not done right. For example, if it gives entrepreneurs the illusion that they don't have to work to acquire customers, invest in direct sales, or provides a (false) sense ...
May 18, 2018•30 min•Ep 382•Transcript available on Metacast “The rules of the game are different in tech,” argues — and has long argued, despite his views not being accepted at first — W. Brian Arthur, technologist-turned-economist who first truly described the phenomenon of “positive feedbacks” in the economy or “increasing returns” (vs. diminishing returns) in the new world of business… a.k.a. network effects. A longtime observer of Silicon Valley and the tech industry, he’s seen how a few early entrepreneurs first got it, fewer investors embrace it, e...
May 17, 2018•1 hr 5 min•Ep 381•Transcript available on Metacast In this hallway-style conversation (originally recorded as a video), a16z general partner Alex Rampell and Terry Angelos, SVP of Commerce Solutions at Visa, discuss the trials and tribulations of their time as co-founders of TrialPay, an e-commerce payment and promotions platform. The story begins with their serendipitous initial meeting twelve years ago; tracks the obstacles overcome, rise, and eventual acquisition of TrialPay (by Visa in 2015); and ends with reflections on the future landscape...
May 10, 2018•46 min•Ep 380•Transcript available on Metacast What challenges do first-time founders or tech founders encounter when building companies in the bio space, and how do they differ from traditional tech companies? In this hallway-style conversation episode of the a16z Podcast (originally recorded as a video), a16z bio team general partners Vijay Pande and Jorge Conde, with Jeff Low discuss the mindset shifts involved in building bio (particularly therapeutics) companies. They cover everything from different paths to market and different partner...
May 10, 2018•27 min•Ep 379•Transcript available on Metacast with Bryan Caplan (@bryan_caplan), Marc Andreessen (@pmarca), and Sonal Chokshi (@smc90) Signaling and credential inflation -- not learning -- can explain why education pays in the labor market, and why we shouldn't invest (any more) in it, argues Bryan Caplan, economics professor at George Mason University and author of the book The Case Against Education: Why the Education System is a Waste of Time and Money. But is it really... a waste of time and money? Doesn't education have other benefits ...
May 09, 2018•45 min•Ep 378•Transcript available on Metacast with Atul Butte (@atulbutte), Daphne Koller (@daphnekoller), and Vijay Pande (@vijaypande) Whether you’re an academic seeking to move out of research and into industry, or simply interested in working at a bio startup, this episode of the a16z Podcast is for you. It covers everything from how to build a brand in the space when you don’t have one to how the bio and how the healthcare startup ecosystem is different from traditional tech (or traditional pharma), to how to choose the right co-founde...
May 02, 2018•42 min•Ep 377•Transcript available on Metacast with Ray Dalio (@raydalio), Alex Rampell (@arampell), and Sonal Chokshi (@smc90) Can one really apply the lessons of history and of the past to the present and the future, as a way to get what they want out of life? By deeply understanding cause-effect relationships -- clearly expressed, shared with others, overlaid with data, back-tested, modified -- you can build a set of principles/algorithms/recipes for dealing with the realities of your life, observes Ray Dalio in this episode of the a16z P...
Apr 21, 2018•50 min•Ep 376•Transcript available on Metacast Many of the healthcare headlines lately have been about consolidation in the industry: Walmart and Humana; Aetna and CVS; Amazon, JP Morgan, and Berkshire Hathaway. But what does it all mean for patients, and startups -- Will it decrease costs? What opportunities may arise as a result? In this quick hallway-style conversation, originally recorded as a video, some of the partners on the a16z bio team (Jorge Conde and Vijay Pande in conversation with Jeffrey Low) discuss what's going on as we see ...
Apr 16, 2018•8 min•Ep 375•Transcript available on Metacast The creation of each new biotechnology enables a tool, a therapy, or a diagnostic: a molecule, a protein, an app, a platform. And the process underneath isn't just complex in the science and engineering of it, but in the go to market. So who are the stakeholders in this process? In this podcast (which was originally recorded as a video), a16z bio fund general partners Jorge Conde and Vijay Pande give a quick hallway-conversation style overview on the stakeholders -- as well as what the process i...
Apr 16, 2018•7 min•Ep 374•Transcript available on Metacast Hypothesis, test, revise -- that's science. Engineering, however, doesn't quite go that way: You have parts you know and understand (like legos), and then you use those parts to design and build something (like bridges). But the key is that when science -- time-consuming, unpredictable, slow, expensive -- becomes more like engineering -- faster, more methodical/repeatable, cheaper -- you can do new things... or do them in better ways. This means engineering disciplines like mechanical engineerin...
Apr 16, 2018•22 min•Ep 373•Transcript available on Metacast with Lisa Hawke (@ldhawke) and Steven Sinofsky (@stevesi) Given concern around data breaches, the EU Parliament finally passed GDPR (General Data Protection Regulation) after four years of preparation and debate; it goes into enforcement on May 25, 2018. Though it originated in Europe, GDPR is a form of long-arm jurisdiction that affects many U.S. companies -- including most software startups, because data collection and user privacy touch so much of what they do. With EU regulators focusing mos...
Apr 12, 2018•36 min•Ep 372•Transcript available on Metacast with Nicole Forsgren (@nicolefv), Jez Humble (@jezhumble) and Sonal Chokshi (@smc90) From the old claim that "IT doesn't matter" and question of whether tech truly drives organizational performance, we've been consumed with figuring out how to measure -- and predict -- the output and outcomes, the performance and productivity of software. It's not useful to talk about what happens in one isolated team or successful company; we need to be able to make it happen at any company -- of any ...
Mar 28, 2018•45 min•Ep 371•Transcript available on Metacast Few operators become VCs, and even fewer go back to leading companies... so how does these perspectives change how one leads? Obviously, it's a lot easier to think of a solution than execute on one... but then how does a leader empower one's team to do the right thing without micromanaging or without being frustrated when they're not getting what they wanted? (Hint: it has to do with providing context). In this episode of the a16z Podcast, Andy Rachleff (president and CEO of Wealthfront and alum...
Mar 26, 2018•22 min•Ep 370•Transcript available on Metacast Leadership is not just about management, but about passion, a bit of humor, and resilience. General partner Peter Levine and Dick Costolo (entrepreneur, former CEO of Twitter, and erstwhile comedian) share their thoughts on the topic in this episode of the a16z Podcast -- based on a conversation recorded as part of the BreakLine program (hosted at Andreessen Horowitz) preparing military veterans transitioning into tech careers. Among other things, Costolo shares what running Twitter was like pre...
Mar 23, 2018•23 min•Ep 369•Transcript available on Metacast Focusing only on the technical, "crunchy, wonky stuff" behind policies or products sometimes misses the humanity at the center of why we're doing the thing in the first place. Because systems -- whether algorithms and artificial intelligence, or capitalism and other such "operating systems" -- need to work for people, not the other way around. Or so observes economist and author Arthur Brooks, president of the American Enterprise Institute (AEI) -- a public policy think tank ...
Mar 21, 2018•24 min•Ep 368•Transcript available on Metacast with Kristen Fortney (@kpfortney), Jeff Kaditz (@jeffkaditz), David Sinclair (@davidasinclair), and Hanne Tidnam (@omnivorousread) Even without a mythical fountain of youth, scientific advances have already dramatically increased how long humans live. But those advances to date have also largely been due to lower mortality rates, less infectious disease, and better nutrition. So when will modern medicine increase not just our healthspan, but our lifespan -- slowing down and possibly even reversi...
Mar 16, 2018•18 min•Ep 367•Transcript available on Metacast with Cristina Cordova (@cjc), Augusto Marietti (@sonicaghi), Laura Behrens Wu (@laurabehrenswu), and Sonal Chokshi (@smc90) APIs (application programming interfaces), observe the guests in this episode of the a16z Podcast, can be described as everything from Lego building blocks to Tetris to front doors to even veins in the human body. Because the defining property of APIs is that they're ways to send and receive information between different parts, that is, communicate between software applicat...
Mar 13, 2018•31 min•Ep 366•Transcript available on Metacast What happens when monolithic architectures are broken down into containers and microservices (or when things are broken down into smaller units, not just in infrastructure but perhaps even in company structure too)? From building more dynamic websites to monitoring the enterprise cloud to elastically scaling applications, where are developers in the enterprise going now and next? This episode of the a16z Podcast, based on a panel by and for developers recorded at the a16z Summit in November 2017...
Mar 08, 2018•18 min•Ep 365•Transcript available on Metacast When most people think of space, they think of outer space: Mars, billionaires with rockets, and the “final frontier”. But space innovation is actually playing out right now -- in an immediate and more accessible way, thanks to techonologies getting smaller, faster, and cheaper -- through micro satellites that do everything from map terrain, to telecommunications that can provide connectivity even in remote areas. This episode of the a16z Podcast -- based on an November 2017 a16z Summit conversa...
Mar 04, 2018•15 min•Ep 364•Transcript available on Metacast with Joel de la Garza, Stina Ehrensvärd, Niels Provos, and Martin Casado Given the heated discussions around security and the c-word (“cyber”), it’s hard to figure out what the actual state of the industry is. And clearly it’s not just an academic exercise — it is a matter of both business survival and personal safety. As cyber, physical, and national security become one and the same, how does that make us rethink how businesses address the problem, from software to hardware? And where do consum...
Feb 28, 2018•18 min•Ep 363•Transcript available on Metacast 
