Moore's Law -- putting more and more transistors on a chip -- accelerated the computing industry by so many orders of magnitude, it has (and continues to) achieve seemingly impossible feats. However, we're now resorting to brute-force hacks to keep pushing it beyond its limits and are getting closer to the point of diminishing returns (especially given costly manufacturing infrastructure). Yet this very dynamic is leading to "a Cambrian explosion" in computing capabilities… just look a...
May 13, 2017•27 min•Ep 294•Transcript available on Metacast A board veteran who has sat on both sides of the table, CEO of PagerDuty Jennifer Tejada shares what you gain from board membership (vs. being only an operator). How does being a board member change you as a CEO, and vice versa? Recorded as part of our annual Director's College held at Stanford University in April 2017, Tejada (in conversation with a16z operating partner Margit Wennmachers) in this episode of the a16z Podcast offers advice about the importance of diligence on both sides, subject...
May 11, 2017•20 min•Ep 293•Transcript available on Metacast It’s the end of the beginning — not the beginning of the end — for wearables, argue the guests in this episode of the a16z Podcast. Especially as we move from the first, to the next, generation of wearable devices: not just activity trackers and watches but VR/AR gear, “hearables”, continuous glucose monitors, and more. The quantified self movement then takes these empirical tracking- and data-gathering tools to better reason about what works and doesn’t work in our bodies to help us solve probl...
May 01, 2017•32 min•Ep 292•Transcript available on Metacast The first thing that comes to mind when treating health problems is the need to take a pill (or other pharmaceutical) of some kind. But could a digital therapeutic -- a software-based intervention -- not only complement, but possibly even replace pills? In this episode of the a16z Podcast, CEO of Omada Health Sean Duffy and a16z bio fund general partner Vijay Pande (in conversation with Malinka Walaliyadde) discuss the potential of digital therapeutics, which use software, design, and other care...
Apr 28, 2017•26 min•Ep 291•Transcript available on Metacast In this hallway-style episode of the podcast, a16z partners Connie Chan and Kyle Russell discuss recent announcements at Facebook's annual developer conference, F8, in the context of trends such as: messaging and QR codes; brain computer interfaces; augmented reality and social VR; and, bots (again). As online platforms built on "real" identity and brands bring more of the real world into the digital realm, will we experience filter fatigue... or will the mundane become more profound? ...
Apr 25, 2017•29 min•Ep 290•Transcript available on Metacast Is it real or science fiction to dream of being able to treat… getting old? In this episode, we discuss with Dr. Thomas Rando from Stanford (who directs the Glenn Center for the Biology of Aging), Kristen Fortney, CEO of BioAge, and a16z’s general partner Vijay Pande where we are in the field of “geroscience” — the idea of studying, well, aging itself, and aging as the root risk for all aging related disease. Far from science fiction, recent discoveries have given us a whole crop of promising br...
Apr 18, 2017•29 min•Ep 289•Transcript available on Metacast A crisis is an opportunity to change one's culture, to model scenarios and set up a crisis plan/process, to become a better company. But it's also a bit like therapy, from the act of asking probing questions to get at the facts ... to dealing with emotions and conflicting agendas. In this hallway-style conversation with a16z's Margit Wennmachers and Kim Milosevich -- who previously shared the why, how, and when of public relations -- we (with Sonal Chokshi) explore the process and mindsets behin...
Apr 13, 2017•34 min•Ep 288•Transcript available on Metacast Here’s what we know about open source: Developers are the new buyers. Community matters. And there will never be another Red Hat (i.e., a successful “open core” business model … nor do we necessarily think there should be). Yet open source is real, and it’s here to stay. So how then do companies build a viable business model on top of open source? And not only make money, but become a huge business, like the IBMs, Microsofts, Oracles, and SAPs of the world? The answer, argues James Watters, has ...
Apr 11, 2017•29 min•Ep 287•Transcript available on Metacast The culture of open source has changed across generations, from previous ones that had to fight for the brave new way -- to the current "GitHub generation" that not only accepts open source, but expects it as the default. Which makes sense given that open source powers so much of the software world today... and by the way, that's not just tech companies but hospitals and banks; it touches everyone. Open source culture has also moved away from cults of personality and top-down models to...
Apr 08, 2017•40 min•Ep 286•Transcript available on Metacast Most of us have probably heard of bitcoin and ethereum -- but did you know there were 15 new cryptocurrencies launched this past month alone? How then do we know which protocols to invest in -- not just as a developer or user, but as an investor? Because, let's face it, open source software and services need resources not just to survive but thrive. General partner Chris Dixon talks about this dynamic between open vs closed in this episode of the a16z Podcast in conversation with Sonal Chokshi a...
Apr 03, 2017•33 min•Ep 285•Transcript available on Metacast In this episode of the a16z Podcast recorded at our inaugural Summit, Jonathan Downey, CEO of Airware, Grant Jordan, CEO of Skysafe, and Kyle Russell, partner at a16z, discuss our future with “eyes in the sky.” How do you balance experimentation and following the rules in a space where people have fears about what a future with drones might look like? This conversation covers the most interesting enterprise use cases for commercial drones, where we are in the introduction of drones into the cons...
Mar 25, 2017•20 min•Ep 284•Transcript available on Metacast An aerospace engineer who worked for NASA for over 40 years, Dr. Christine Darden is one of the mathematicians that the book and movie Hidden Figures was based on. Darden eventually would lead the sonic boom team, going on to become the first African-American woman in senior management at NASA. In this intimate conversation with a16z’s general partner Jeff Jordan, held at the SF Jazz Center, Darden shares with Jordan how she first fell in love with geometry and math; the effect that Sputnik had ...
Mar 22, 2017•38 min•Ep 283•Transcript available on Metacast As we enter a new era of distributed computing -- and of big data, in the form of machine and deep learning -- storage becomes (even more) important. It might not be sexy, but storage is what makes the internet and cloud computing go round and round: "Without storage, we wouldn't have databases; without databases, we wouldn't have big data; we wouldn't have analytics ... we wouldn't have anything because information needs to be stored, and it needs to be retrieved." This is especially ...
Mar 21, 2017•22 min•Ep 282•Transcript available on Metacast A lot of machine learning startups initially feel a bit of “impostor syndrome” around competing with big companies, because (the argument goes), those companies have all the data; surely we can’t beat that! Yet there are many ways startups can, and do, successfully compete with big companies. You can actually achieve great results in a lot of areas even with a relatively small data set, argue the guests on this podcast, if you build the right product on top of it. So how do you go about building...
Mar 17, 2017•22 min•Ep 281•Transcript available on Metacast Your brand, says head of a16z marketing and Outcast Agency co-founder Margit Wennmachers, is what people say about you when you're not in the room. And it's going to happen, whether you choose to have an active part in it or not. But what does this mean at an individual, not just company/product level? In this episode of the a16z Podcast, Wennmachers and Outcast CEO Alex Constantinople -- both longtime veterans of public relations and building executive profiles -- de-mystify what having and bui...
Mar 13, 2017•32 min•Ep 280•Transcript available on Metacast Starbucks supposedly spends more on healthcare than it does on coffee beans. And 20 years ago, says Rajeev Singh, CEO of Accolade, healthcare was 10% of GDP; today it’s 19% -- that's nearly one-fifths of our gross domestic product. So what tools do we have to address the high costs of health care, especially as stakeholders increasingly look for value-based care? This episode, recorded at our a16z inaugural Summit and moderated by Vijay Pande (a16z general partner on the bio fund) discusses appr...
Mar 09, 2017•18 min•Ep 279•Transcript available on Metacast In this episode of the a16z Podcast introduced by Vijay Pande (based on a presentation at our summit event), Russ Altman, Stanford professor of bioengineering -- and former chairman of their Bioengineering Department -- takes us on a short but deep tour of the possibilities of genomics in drug discovery. Including how building a large bank of human genetic variations will change our understanding and optimization of drug response. Altman (who also hosts his own radio show, "The Future of Ev...
Mar 07, 2017•14 min•Ep 278•Transcript available on Metacast The irony of our systems working so well -- technological, corporate, and yes, even political -- is that we've become too comfortable: matching to others just like us, producing less, taking fewer risks. But isn't the very point of technology to make our lives more comfortable? Yes... until "we" -- whether an entire class, generation, ethnic group, or country like the U.S. -- become a little too complacent. Or so argues Tyler Cowen in his new book, The Complacent Class: The Self-Defeat...
Mar 01, 2017•38 min•Ep 277•Transcript available on Metacast Humans have always wanted to enhance themselves -- from getting nutrition just-right to optimizing their performance, whether in sports or health or work. And food is a big part of all that. But our current systems of food production (and consumption) are far from efficient and sustainable let alone optimizable. That's where a whole new generation of wearable/ bio-feedback, food and nutrition, food production, and performance enhancement/ "nootropics" companies come in. How do these ap...
Feb 28, 2017•20 min•Ep 276•Transcript available on Metacast Imagine, for a moment, an alternative universe: One where Netflix got disrupted by some other streaming-content company that made its DVD rental business irrelevant. But that's just a counterfactual. What happened instead is that Netflix cannibalized (or rather, "hybridized") its own core business to make room for a more strategic one given where the tech was going. Given how rare it is for companies to successfully disrupt themselves like this, Reed Hastings, CEO and co-founder of Net...
Feb 26, 2017•46 min•Ep 275•Transcript available on Metacast Evolution and technology have allowed our human species to manipulate the physical environment around us -- reshaping fields into cities, redirecting rivers to irrigate farms, domesticating wild animals into captive food sources, conquering disease. But now, we're turning that "innovative gaze" inwards: which means the main products of the 21st century will be bodies, brains, and minds. Or so argues Yuval Harari, author of the bestselling book Sapiens: A Brief History of Mankind and of...
Feb 23, 2017•44 min•Ep 274•Transcript available on Metacast It's been nearly 15 years since the Human Genome Project was completed. But "are we there yet" in the golden age of genomics? What did we think we'd have by now, what do we actually have, and what do we really still need to make genomics live up to its promise? Well, one thing we now understand is that our DNA isn't static; in fact, it changes at an absolutely crazy rate. We also need to add more context -- about mutations, about somatic tissue, about phenotypes, about each person's un...
Feb 22, 2017•26 min•Ep 273•Transcript available on Metacast The hardest thing about pivots (major shifts in company/product direction) isn't just the actual pivot. It's the courage to make the decision... and being honest with yourself as a CEO. Especially since, no matter how great the team or board or even customers may be, it's lonely: You're the only one in the position to synthesize the knowledge; nobody else has the data and the insight put together in the same way. And sigh, "pivot" has also become such an overused word, it's certainly l...
Feb 19, 2017•32 min•Ep 272•Transcript available on Metacast The modern enterprise holds all sorts of applications, devices, and workflow needs. How should we be thinking about securing infrastructure -- and identity -- in this context, for entities like major news media outlets or financial institutions such as News Corp or NASDAQ? Well, this episode of the a16z Podcast brings those voices together: Frederic Kerrest, cofounder and COO of Okta; Brad Peterson, CIO of NASDAQ; and Dominic Shine, CIO of News Corp ... in conversation with Ben Horowitz at our r...
Feb 14, 2017•19 min•Ep 271•Transcript available on Metacast Thanks to freeways, cities became something to get through instead of something to get to. Now, as the next transportation revolution -- from rivers to trains to cars to autonomous cars -- promises to change the face of our cities, what happens to car culture, infrastructure, and more? Who owns what, who pays? And what about the design -- and product management -- challenges, whether it's designing for user trust, city adoption, or an ever-moving target thanks to constantly evolving tech? This e...
Feb 08, 2017•36 min•Ep 270•Transcript available on Metacast In the age of the internet -- where information is freely available online, and connections between sellers and buyers of software products are visible on LinkedIn -- do analysts really matter? Do they play a role in decision-making for purchases from smaller vendors like tech startups, especially given the rise of the developer as a buyer? Or what if you're trying to create a new category ... do you need to be on a Gartner Magic Quadrant or Forrester Wave or similar? We answer these questions a...
Feb 01, 2017•31 min•Ep 269•Transcript available on Metacast Once upon a time, Robert Stromberg got a phone call from "Jim" Cameron (aka James Francis Cameron of Terminator and Titanic fame) about a little project called Avatar. Before he knew it, he was responsible for designing the organic world of Pandora, from bioluminescent plants to lush mountaintops. That was when Stromberg realized how much more technology could do, when ready, for creating more such virtual worlds. He'd actually been creating such worlds for ages, from drawing monsters ...
Jan 27, 2017•38 min•Ep 268•Transcript available on Metacast "Punch above your weight" -- If there's one thing public relations (PR) should help startups and founders do, it's that. Unfortunately, some companies are actually punching below their weight when there's a strong company, founder, product ... yet nobody knows about let alone talks about you. Or worse, someone else defines you first. Or you just become a hype machine. So what conversations should you be in? Is it good or bad to do PR before you have a product? And operationally, WHEN i...
Jan 26, 2017•42 min•Ep 267•Transcript available on Metacast The building blocks for VR and AR are finally here -- but the content is just beginning. So everything you'll actually experience and consume in these new mediums over the next few years is being built right now. Formats aren't yet defined or locked down, and the field is bubbling up with experiments in forms, formats and genres, from narrative to games to live events. As we begin to have real time rendered characters and AI-driven environments that you can interact with, the storytelling struct...
Jan 24, 2017•26 min•Ep 266•Transcript available on Metacast How to think about business policy and top-of-mind issues for the tech industry, given a new president? From what agencies matter for startups and VC to what the first 100 days (and next two years!) look like, a16z managing partner Scott Kupor and president and CEO of the National Venture Capital Association (NVCA) Bobby Franklin share what happens between elections and when the reality of the Washington process sets in post-inauguration. What are some of the discussions that are happening aroun...
Jan 21, 2017•24 min•Ep 265•Transcript available on Metacast 
