How to think about tech policy and top-of-mind issues for the tech industry, given a new president? From what agencies matter for different tech domains -- e.g., autonomous cars, drones, fintech, healthcare -- to recent staffing moves, the a16z Policy and Regulatory Affairs team shares their views in this episode of the podcast. What happens to tech policy when you have a dominant Republican presence in both Congress and most states, yet a Democratic majority of mayors? Especially when cities (p...
Jan 21, 2017•40 min•Ep 264•Transcript available on Metacast "Mobile-first" (and now too AI-first) has been a mantra of sorts in design, but what does that mean at a company, product management, and competitive level? Especially when someone in company X will always say "we should do what Y did" -- even if they have no idea let alone data why Y did it. And while designing for screens is "like growing a carp in a bathtub" (will inevitably grow to the size of the container), what do design constraints mean in an increasingly sc...
Jan 18, 2017•30 min•Ep 263•Transcript available on Metacast The largest asset class in the United States is owner-occupied real estate, yet options for homeowners accessing this are very binary right now: either own 100% of your home (with a mortgage), or own nothing. And when people do “own”, that ownership is often skewed by debt. Of course, debt works out great for some, given their risk profiles and potential upside (if the house keeps appreciating); but the downside risk and costs are disproportionately borne by the homeowner. And millennials can’t ...
Jan 13, 2017•30 min•Ep 262•Transcript available on Metacast From the significance of Google DeepMind's AlphaGo wins to recent advances in "expert-level artificial intelligence" in playing an imperfect/ asymmetric information game like poker, toys and games have played and continue to play a critical role in advancing machine intelligence. One of the pioneers in this area among others is the Alberta Innovates Centre for Machine Learning -- now the Alberta Machine Intelligence Institute (amii) -- which in 2007 solved the long-standing challenge o...
Jan 11, 2017•27 min•Ep 261•Transcript available on Metacast What (on earth) does it take to get a signal to Pluto? Stanford senior scientist and astronomer Ivan Linscott, part of the team that ran the radio science experiment on the New Horizons probe, shares in conversation with a16z's Frank Chen all the nitty gritty details about their project using Ruse radio transmissions to gather info about Pluto. Listen in on exactly what it really takes to do so -- everything from commandeering old Cold War spy technology and plutonium to completing the entire mi...
Jan 01, 2017•49 min•Ep 260•Transcript available on Metacast As companies expand out from the internet into the rest of the economy — the proverbial bits to atoms — “the business models are becoming more complicated, more interesting, more payment based”, observes Patrick Collison, CEO and co-founder of payments platform Stripe, which enables apps/websites to programmatically move money around. But as such companies become “the operating platform for commerce”, we also have an interesting paradigm where people, not governments, are controlling the commerc...
Dec 31, 2016•27 min•Ep 259•Transcript available on Metacast As people live longer, aging is more top of mind than ever. This is especially true for the "sandwich generation" wedged between caring for aging parents as well as young children at the same time. The fact is, the 65+ year old population (but don't you dare homogenize a multi-decade age group!) will double over just the next 15-20 years. So how does this fit into our current healthcare system? How does it fit current retail experiences, like for buying adult diapers? What are the desi...
Dec 27, 2016•32 min•Ep 258•Transcript available on Metacast "We throw around words like 'crisis' very easily, but this is a global crisis, and it is of historic proportions," says current U.S. Deputy Secretary of State Tony Blinken about the refugee crisis (for which he and his department mobilized a response that significantly accelerated government efforts to assist refugees, as well as engage the tech sector). "People don't realize that before 2011, the number of Syrian refugees was zero," shares Lina Sergie Attar of the non-profit...
Dec 16, 2016•34 min•Ep 257•Transcript available on Metacast Nature is the ultimate complex system, of course — but with today’s technology, it’s now provided us with an “incredible toolkit” of different molecules that material scientists can treat like Legos to make some really interesting products. One of those is a protective layer for fruits and vegetables that extends shelf life and freshness. Because all produce is seasonal, it’s perishable — so there’s a limited geographical radius around which it can travel… whether by land, sea, or air. How does ...
Dec 14, 2016•35 min•Ep 256•Transcript available on Metacast Clearly disruption plays out not just in business but also in politics. Whether it was the Scottish national party, recent election campaigns, or local school boards, people grew and organized communities online all last year through NationBuilder -- which provided a software platform for those otherwise underserved from an established technology perspective (hence the disruption theory reference). Harnessing the energy of communities goes beyond politics though, to all kinds of movements. But w...
Dec 09, 2016•22 min•Ep 255•Transcript available on Metacast "We live in a world where we use millions of variables to predict which ad you're going to click on. Whether or not you deserve to get a loan. What movie you might watch next. But when it comes to our bodies and even serious diseases, we want to reduce things down to just one or two variables." It's insane that we actually collect so little data about our bodies. The modern day physical is downright spartan in what it captures, not to mention that we're using 200-year old tools to capt...
Dec 05, 2016•30 min•Ep 254•Transcript available on Metacast The Industrial Revolution (and period between 1500-1700) was an unprecedented age of technology and economic progress — not unlike today’s, in fact — where we took “quantum leaps” forward in tech by taming electricity, making cheaper steel and refining iron cheaply, automating fiber looms, pumping water out of coal mines, figuring out how to measure longitude at sea, improving the quality of food, preventing smallpox, … even bleaching underwear. But what really triggered the Industrial Revolutio...
Nov 27, 2016•36 min•Ep 253•Transcript available on Metacast “If we have instant delivery for our burgers,” says Zipline CEO and co-founder Keller Rinaudo, “we should have it for our medicine.” So while some people debate whether drone delivery for burritos, beers, and books is a marketing gimmick, one of the most important kinds -- urgent delivery of urgent healthcare -- is happening right now through Zipline’s delivering blood and vaccines to patients and hospitals in Rwanda. The peace dividend of the smartphone (and electric vehicle) wars has yielded c...
Nov 23, 2016•22 min•Ep 252•Transcript available on Metacast You’ve heard the numbers or some statistic like this: By the year 2050, we’ll need to feed 9.7 billion humans on the planet. Our current production and meat-making methods -- growing crops to feed to animals to turn them into food -- can’t keep up … not to mention it’s not very good for the environment. Yet meat is at the center of the plate for most meals, for most people. So how do we go from where we are to where we need to be? Especially since food is fundamentally an emotional experience! Y...
Nov 23, 2016•25 min•Ep 251•Transcript available on Metacast You've heard a version of this story before: Steve Jobs calls some executive out of the blue to come work for him. Only this time the story turns out great ... and the company wasn't Apple. This episode of the a16z Podcast shares some of the journey that former CFO Lawrence Levy went on with Steve Jobs as they took Pixar -- a company then on the verge of failure -- to its IPO and subsequent greatest hits. It's sort of an adventure story but is really more of a quest for product-market fit. How d...
Nov 09, 2016•30 min•Ep 250•Transcript available on Metacast We live in very interesting times, to say the least -- whether it's a shift in how technology is built and adopted today compared to the past; a changing international landscape with leapfrogging players; or an increased cyberattack surface as computing and networking touch everything. So what's next for technology and national security? This episode of the a16z Podcast is based on a conversation that took place last month between Marc Andreessen and Michèle Flournoy -- former Under Secretary of...
Nov 09, 2016•34 min•Ep 249•Transcript available on Metacast In business, as in politics, "the movement is the message" -- whether that "movement" is a product that's taking off grassroots-style in an enterprise, or is a political candidate. In fact, you can think of political campaigns in general as a lot like startups ... only there's no second place in politics! And you can definitely think of business -- and in particular go-to-market strategy -- as a lot like political campaigns: in allocating marketing resources, going up against...
Nov 03, 2016•27 min•Ep 248•Transcript available on Metacast There have been a number of new device announcements this past month -- from Google’s new Pixel phone (the first time they made their own phone on the hardware side as well) to more recently, Apple’s announcements around a new Macbook Pro and innovations in touch (including a Touchbar that replaces function keys and bringing TouchID to Macs); and then Microsoft, which among other things announced a new Surface Studio -- an all-in-one touchscreen desktop PC. How do these change the future of work...
Oct 29, 2016•34 min•Ep 247•Transcript available on Metacast Once we sequenced the human genome, we'd know the cause of -- and therefore be able to help cure -- all diseases... Or so we thought. Turns out, 20,000 genes (and counting) didn't really explain why disease occurred. Sure, some could be explained by mutations in a single genome, but most, like cancer, are too damn complex. And while the focused, singular approach to understanding disease did yield some useful therapeutics, it's now reached its limits. It hasn't helped much on the diagnostics (an...
Oct 18, 2016•31 min•Ep 246•Transcript available on Metacast From glittery reaction gifs modded by grandparents to rage faces on Reddit, stickers (gifs and other layered images) and emotive “biaoqing” have taken over messaging culture in China and beyond. Stickers are tied to filter culture, too — whether originating in real life as purikura photo sticker booths in Japan or digitally as Snapchat filters. Why are these forms of social communication so popular? Because sometimes you just want to say “I feel totally Nicki Minaj side-eye dot-GIF about this”, ...
Oct 12, 2016•47 min•Ep 245•Transcript available on Metacast The most recent Oculus Connect event (the third and largest yet) has been lauded as bringing us closer than ever to the future promised for virtual reality or VR. There have been many hardware moves by many players, both recently and over the past year. Who's in it to win it? How far are we from the "holy grail" of headsets that will truly mainstream VR? Will the killer app -- or layer -- for VR be social? And is there enough enthusiasm and activity to get us past the "trough of d...
Oct 10, 2016•36 min•Ep 244•Transcript available on Metacast This special episode of the a16z Podcast is based on a Q&A from an early screening we hosted of Disney's Queen of Katwe, now in theaters. The movie -- directed by Mira Nair and based on a book by Tim Crothers -- depicts the true story of Ugandan chess prodigy Phiona Mutesi. The conversation, hosted by Ben Horowitz, features actor David Oyelowo who (among other roles, previously played Dr. Martin Luther King, Jr. in "Selma") and plays Robert Katende, the engineer-turned-mentor who t...
Sep 30, 2016•22 min•Ep 243•Transcript available on Metacast From the silver age of on-prem software companies like SAP and Siebel Systems to the golden age of enterprise software-as-a-service, we're now seeing an explosion of data. All types, all sizes, and all over the place. And much of it is a sort of industrial "data exhaust", where companies aren't quite sure what question to ask of the data but are being bombarded with data due to the variety of data sources available today -- from websites to sensors (and therefore data capture) everywhe...
Sep 22, 2016•28 min•Ep 242•Transcript available on Metacast Just as "social networking" is a bland term that doesn't really capture the layers of what happens underneath (and on top of) social networking platforms, "crowdfunding" is a broader phenomenon than what the term and tools implies. Or so argue the guests on this episode of the a16z Podcast, Tilt co-founder and CEO James Beshara and a16z general partner Jeff Jordan with Sonal Chokshi. Crowdfunding isn't just about reaching a certain threshold to make something, but it's also a...
Sep 18, 2016•28 min•Ep 241•Transcript available on Metacast "Apple isn't just a tech company; it's a tastemaker." Remember the iconic ads of dancing silhouettes in black, with only the headphone wires visible in white? They were a critical part of the larger buy-Apple innovation narrative. So what happens now when those wires -- an emblematic and enduring image -- are no longer visible, as is the case with the removal of the traditional headphone jack in iPhone 7? It's part of a broader story, both about how product narratives are shared/told a...
Sep 13, 2016•34 min•Ep 240•Transcript available on Metacast Sleep, productivity, and creatively are intimately linked, for better and for worse. And "we are living under a collective delusion that burnout is the way to succeed," observes Arianna Huffington, author of The Sleep Revolution. Not only does this affect our health and resilience, she argues, but the data shows that even though we are working longer hours than ever, we lose 11 days of productivity a year per employee due to sickness or diminished capacity. (It also hurts our ability t...
Sep 06, 2016•28 min•Ep 239•Transcript available on Metacast "Incremental change may be good theory, but in practice you have to have a big enough stick to hit everybody with to make everything move at once". So shares Adrian Cockcroft, who helped lead Netflix's migration from datacenter to the cloud -- and from monolithic to microservices architecture -- when their streaming business (the "stick"!) was exploding. So how did they -- and how can other companies -- make such big, bet-the-company kind of moves, without getting mired in fa...
Aug 31, 2016•27 min•Ep 238•Transcript available on Metacast For better or worse, most of the computing systems that run much of our lives (whether invisibly or visibly) have become increasingly complex -- they're not fully engineered; they're almost grown. And with that we enter a brave new world of "biological" (as opposed to a more "physics") mindset applied to computing. It's more like evolution, horns and all. This isn't just abstract or backend-only stuff. Complex system design affects everything from datacenters and SaaS to word...
Aug 30, 2016•19 min•Ep 237•Transcript available on Metacast Bitcoin quickly made its way from a whitepaper to a production network, which is pretty amazing when you think about it. But its scripting/ programming language was initially, intentionally, limited for a few reasons, which meant that building new apps on bitcoin wasn't always easy. Enter ethereum in 2014 -- a public blockchain platform that moved away from the "Swiss-army knife" approach to a more general protocol approach. This would in turn allow endless (and entirely new) use cases...
Aug 28, 2016•50 min•Ep 236•Transcript available on Metacast Now that we know to price and plan early, price high -- especially for category-creating or "pre-chasm" businesses -- how do we handle freemium models? While free to premium is a great way to get bottoms-up, often viral traction in an enterprise, the challenge is figuring out just where and how to "draw the line" between where free ends and paid begins. Especially for open source, which while not necessarily free/mium, is also affected by these questions. And in that case, ho...
Aug 19, 2016•33 min•Ep 235•Transcript available on Metacast 
