Tracking the Trends: AI, WebRTC, Crypto, and Full Stack Startups

How to Decide, Convey vs. Convince, & More

It seems like investors are especially obsessed with the psychology of decision making -- high stakes, after all -- but all kinds of decisions, whether in life or business -- like dating, product management, what to eat or watch on Netflix -- are an "investment portfolio" of decisions... even if you sometimes feel like you're making one big decision at a time (like, say, marriage or what product to develop next or who to hire). Obviously, not all decisions are equal; in fact, sometimes we don't ...

Fintech for Gen Z and Millennials

Millennials and Gen Z have been hard-hit by the one-two punch of the 2008 and 2020 financial crises. That experience has radically shaped their approach to finances and their mindset around credit and debt. This episode explores how fintech founders are now designing products tailored to the financial challenges of younger consumers, from managing and avoiding student loans to building credit to saving and budgeting apps. Historically, students have largely been overlooked by traditional banks. ...

Degrading Drugs for Problem Proteins: Journal Club now on Bio Eats World (ep 2)

Welcome to the second episode of Bio Eats World , a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine. Many diseases are caused by proteins that have gone haywire in some fashion. There could be too much of the protein, it could be mutated, or it could be present in the wrong place or time. So how do you get rid of these problematic pr...

The Biology of Aging: Introducing Bio Eats World (ep 1)

Welcome to the first episode of Bio Eats World , a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine. In this episode, we talk all about the science of aging. Once a fringe field, aging research is now entering a new phase with the first clinical trials of aging-related drugs. As the entire field shifts into this moment of translation,...

TikTok & Beyond: The Algorithm Question, The Future of Product

With the U.S. tech partnership for TikTok being finalized, what happens if source code is excluded (and more specifically, the For You Page algorithm), given China’s revised export controls ? But more broadly -- well beyond the specifics and politics of this deal -- what does the success of TikTok tell us about “creativity network effects”, where every additional creator makes the rest of the community more creative? How did "seeing like an algorithm" and the new age of algorithm-friendly produc...

The New Fan Club: Creators, Fans, and the Power of Markets (& Crypto)

Today’s episode, part two in our two-part series on the Creator Economy, focuses on the new potential revenue streams and fan-engagement models opened up by emerging decentralized technology. It's a new type of fan club, driven by crypto networks and aiming to give creators more power in the commercial sphere. Zoran Basich of a16z talked to two guests deeply immersed in these topics. Kayvon Tehranian is the founder and CEO of Foundation Labs, a platform for buying and selling limited edition goo...

So You Want to Launch a Newsletter: Tips From Substack Writers

This episode, part one in a two-part series on the Creator Economy, explores the process and economics behind creating an independent newsletter. In this candid conversation, host Lauren Murrow talks with four Substack writers—an artist, a technologist, a journalist, and a clinical researcher-turned-psychedelics scholar—about how to find and foster an audience, the calculus behind going paid versus unpaid, the pressure to produce, and financial benchmarks for making a living from newsletter writ...

Designing a Culture of Reinvention

Since Netflix started in the late 90s as a DVD-by-mail rental service competing with Blockbuster, it has completely reinvented itself... twice – first, when it went from DVD rental to video streaming platform, and then again when it went from licensing to producing original content. But what does it take to create an organization capable of reinventing itself? In this episode, originally recorded for the Commonwealth Club of California, Netflix CEO and co-founder Reed Hasting talks about his new...

Heroes & Myths in Entrepreneurship -- Guy Raz

"I'm in a movie, but it's the wrong movie." For better or for worse, we tell the story of entrepreneurs as one of the mythical hero's journey: that's there's a call, a test (multiple tests!), a destination... But nothing truly follows such a clean, linear, storytelling arc. Stories of success and resilience are messy and full of "sleepless nights, anxiety-ridden fears, moments of real despair and failure", observes Guy Raz -- who is the host, co-creator, and editorial director of three NPR progr...

The Question of Education

Monopoly, oligopoly, cartel. All three of those words can describe the (not so) modern education system today, given the cost structures, economics, and accreditation capture -- in everything from who can and can't start a new university (when was the last time a significant change happened there anyway?!) to where government funding really goes to the student loan and debt crisis. Yet degrees do matter, just not for the reasons we think. So what are the tradeoffs -- when it comes to the "right"...

Pandemic Relief and Fraud: Willful Deceit or Design Defect?

This episode examines the potential for misuse and fraud among those applying for the Paycheck Protection Program (PPP)—and how fintech and software provide overlooked tools to stop it. On March 27th, the government enacted a $2.2 trillion dollar stimulus package called the CARES Act, the largest aid measure in history. The act provides more than $500 billion for the Paycheck Protection Program, or PPP, a low-interest, forgivable loan program designed to help small businesses and self-employed i...

Measuring & Managing Community Orgs, Developer Relations and Beyond

Okay, so we know community is important -- whether for developer relations for your product or other types of communities -- but how do we measure the success of community initiatives and even artifacts (like events or schwag), given how indirect and long-cycle so much of it is? How do we know we're even measuring the right things, and is there one key metric or KPI for measuring the health of a community? Where do "meta communities" or where does engaging key community leaders come in? And when...

Reining in Complexity: Data Science & Future of AI/ML Businesses

There is no spoon. Or rather, “There is no such thing as ‘data’, there’s just frozen models”, argues Peter Wang , the co-founder and CEO of Anaconda — who also created the PyData conferences and grew the early data science community there, while on the frontlines of trying to make Python useful for business analytics. He views both models and data as fluid , more like metaphysics than typical data management… Or perhaps it’s that when it comes to data, those with a physics background just better...

Online Learning and the Ed Tech Debate

This episode is all about education and technology, a topic that’s especially top of mind this week as students in much of the country return to school—virtually. The intersection of learning and technology has been accelerated by the pandemic, but the debate around education's "disruption," and what that means for educators doing the hands-on work of teaching, has been swirling for years. In this episode, a16z general partner Connie Chan and host Lauren Murrow are joined by educators and expert...

On Vaccines and Vaccinology, in COVID and Beyond

WHEN are we going to have a COVID-19 vaccine, and how the heck are we going from (what’s been traditionally been up to) 12 years or so of vaccine development compressed into 12 months or so? What will and won’t be compromised here, and where do new technologies -- like mRNA or messenger RNA vaccines -- come in? Where will vaccines likely be distributed first, who will and won't get them initially, both across populations... and nations? Rajeev Venkayya , president of the Global Vaccine Business ...

Turning Open Source Developers Into Superfans

In this episode, we continue our community series with a recent discussion that applies to many kinds of community building. Today’s topic: How do you create a platform that people not only use, but tell their friends about? One that goes beyond just being useful and actually connects deeply with the user? In this discussion, which was recorded at our Crypto Startup School in April 2020, a16z General Partner Chris Dixon talked about building communities — specifically, communities of open-source...

Journal Club: Slaying the Sleeper Cells of Aging with CAR T

CAR T therapy is a groundbreaking medicine that uses engineered T cells to attack cancer. But CAR T cells (that is, chimeric antigen receptor T cells) can be programmed to recognize a huge range of target proteins and cell types. So what other types of cells should we train CAR Ts to recognize and destroy to improve human health? On this episode of the a16z Journal Club, a16z General Partner Jorge Conde, bio deal team partner Andy Tran, and Lauren Richardson discuss new research published in Nat...

Working, Making, Creating in Public... and Private

We're living in an unprecedented era of online collaboration, coordination, and creation. All kinds of people are coming together -- whether in an open source project or company , an R&D initiative, a department in a company, a club or special interest group, even a group of friends and family -- around some shared interest or activity. But the word "members" is faceless, and doesn't help us really understand, support (and better design for) these communities. So in this special book launch epis...

GPT-3: What's Hype, What's Real on the Latest in AI

In this episode -- cross posted from our 16 Minutes show feed -- we cover all the buzz around GPT-3, the pre-trained machine learning model from OpenAI that’s optimized to do a variety of natural-language processing tasks. It’s a commercial product, built on research; so what does this mean for both startups AND incumbents… and the future of “AI as a service”? And given that we’re seeing all kinds of (cherrypicked!) examples of output from OpenAI’s beta API being shared — how do we know how good...

Taking the Pulse on Medical Device Security

Many don’t realize we even need to think about the possibility of security hacks when it comes to things like pacemakers, insulin pumps, and more. But when bits and bytes meet flesh and blood, security becomes literally a life or death concern. So what are the issues and risks we need to be aware of in exposing security vulnerabilities in connected biomedical devices? This conversation—with Beau Woods, Cyber Safety Innovation Fellow with the Atlantic Council, part of the I Am The Cavalry grassro...

Journal Club: A New Path to Antibiotic Resistance

Ever since the discovery of antibiotics, microbiologists have worried about and studied how bacteria acquire resistance to these drugs. Adding to the complexity of this problem is the fact that it is not always clear whether the conditions that drive the evolution of resistance in the lab occur in patients suffering from bacterial infections. This is where the work of Nathalie Balaban -- Professor at the Hebrew University, and our guest on this episode -- comes in. The article we discuss is base...

Cybercrime, Incorporated

A dive into the sociological, operational, and tactical realities of this murky underworld, Lusthaus and de la Garza discuss who the players are, what they are motivated by, and specialize in—as well as how basic ideas like trust and anonymity function in a world where no one wants to get caught. How do criminal nicknames function as brand? Which countries tend to specialize in what kinds of crime, and why? And most of all, what changes when you begin to think of the business of cybercrime as an...

How Transparent Pricing Drives Healthcare Change

Dr. Marty Makary—surgical oncologist at Johns Hopkins University School of Medicine, and health policy and innovation expert—has long been a passionate advocate for transparent pricing in the healthcare system. We don’t talk enough (or really at all) about price in healthcare, says Makary (instead, we talk about cost). But shedding a light on prices in healthcare—from not just what those prices are but how prices are set and the value we all receive as consumers of the system overall—can help us...

Preserving Digital History: How to Close the Web's 'Memory Hole'

More than 98% of the information on the web is lost within 20 years, and huge gaps exist in our digital and cultural history. Zoran Basich and Alex Pruden of a16z talk to Brewster Kahle and Sam Williams, who are using different approaches to attack this problem. Brewster cofounded the Internet Archive, which is well known for creating the Wayback Machine that crawls a billion URLs every day. Sam cofounded Arweave, a company that uses decentralized crypto networks to store information forever. Fo...

Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship

In part 1 of our series on human performance, we looked at the limits of human potential in climbing and other sports – and how we push those limits through technology and training. In this episode, recorded at our a16z innovation summit last year, Alex talks with a16z general partner and fellow avid climber Peter Levine about the risk, fear, and preparation for his free solo of El Capitan on Yosemite. While climbing is the topic, the conversation holds many lessons for entrepreneurs, and anyone...

Alex Honnold on Human Performance (part 1) – Where's the Limit?

Is there a limit to what humans can do? And if so, how do you know when you've reached it? Welcome to part one of a two-part series on human performance with professional rock climber Alex Honnold. Alex redefined the limits of what is possible by free soloing – that is climbing with no ropes or safety gear – a 2000-foot granite rock face in Yosemite, known as El Capitan. That feat was documented in the award-winning film Free Solo. In this podcast, Alex, a16z general partner Peter Levine (who at...

Why We Shouldn’t Fear AI in Healthcare

"Why We Shouldn’t Fear the ‘Black Box’ of AI (in Healthcare and Everywhere)" by Vijay Pande. First published in the New York Times, January 2018. You can also find and share this article at a16z.com/aidoctor

When One App Rules Them All: The Case of WeChat and Mobile in China

"When One App Rules Them All: The Case of WeChat and Mobile in China" by Connie Chan. First published August 2015. You can also find and share this essay at a16z.com/mobilefirstchina

Every Company Is a Fintech Company

"Why Every Company Will Be a Fintech Company -- The Next Era of Financial Services and the 'AWS Phase' for Fintech" by Angela Strange. You can also find and share this essay at a16z.com/fintecheverywhere