It’s safe to assume that the vast majority of you have a bottle or blister pack of acetaminophen/paracetamol/Tylenol/Panadol in your home medicine cabinet, and an even vaster majority of you have taken the medicine at some point in your life. After all, acetaminophen/paracetamol is one of the most, if not the most, widely used medications worldwide. Despite its near ubiquity, many unanswered questions remain. How does it actually work? Should safe dosage guidelines be revisited? Why on earth doe...
Jul 11, 2023•1 hr 29 min•Transcript available on Metacast Riots over inoculations. Large-scale quarantines and lockdowns. Criticisms of government action (or inaction) during disease outbreaks. The spread of mis- and disinformation about the safety of immunizations. You may be thinking, “this is a COVID episode, isn’t it?”. Not quite. In this latest installment of the TPWKY book club we’ll be discussing another key period in US history that had profound, long-lasting impacts on public health and access to medical care: the American Revolutionary War, w...
Jul 04, 2023•58 min•Transcript available on Metacast In early February and late March of this year, separate outbreaks of Marburg virus were declared in Equatorial Guinea and in the United Republic of Tanzania. For several months, news of these outbreaks and other sporadic cases made headlines globally, as public health officials watched the number of cases and suspected cases climb, calling to mind previous outbreaks of Marburg virus's relative, the deadly Ebola virus. Fortunately, the WHO declared both outbreaks over in early June, but the threa...
Jun 27, 2023•1 hr 17 min•Transcript available on Metacast Are viruses the “great equalizers” that some people claim them to be? Are we all similarly susceptible not only to infection from viruses but also to the consequences from infection? The short answer is no. The longer answer can be found in this week’s book club pick, The Viral Underclass: The Human Toll When Inequality and Disease Collide by Dr. Steven Thrasher. Dr. Thrasher, the inaugural Daniel H. Renberg Chair and Assistant Professor of Journalism at Northwestern University, joins us to disc...
Jun 13, 2023•1 hr 5 min•Transcript available on Metacast An entire generation probably first learned the word “mesothelioma” and its link to asbestos from those ubiquitous commercials in the 1990s and 2000s. You know the one: “if you or a loved one has been diagnosed with mesothelioma you may be entitled to financial compensation.” These commercials made it seem like mesothelioma suddenly came out of nowhere. Was this a newly discovered disease? Wasn’t asbestos banned? How did asbestos cause mesothelioma? Heck, what even was asbestos? By seeking to an...
May 30, 2023•2 hr 39 min•Transcript available on Metacast Where can you find banana-stealing macaques, dumpster-diving bears, flower-destroying gulls, and dangerously-exploding trees all in the same place? In a book by Mary Roach , of course. In this TPWKY book club episode, we’re joined by world’s funniest science writer and award-winning author to chat about her latest book Fuzz: When Nature Breaks the Law , a rollicking tour of the many ways that humans and wildlife clash and the varied attempts to mitigate this conflict. Our conversation carries us...
May 16, 2023•55 min•Transcript available on Metacast This just might be our itchiest episode yet, and for that we sincerely apologize. But it might also be one of our most fascinating and fun episodes yet, and for that we are proud. Whether or not you have personal experience with bedbugs, the mere mention of these vampiric critters is often enough to inspire skin-crawling horror in us all. But in this episode, we also make a case for their appreciation. How can you not admire (from a distance, of course), their incredible ability to go for months...
May 02, 2023•1 hr 29 min•Transcript available on Metacast Menstruation. Is there any other biological process that is so widely experienced yet is still discussed in hushed tones or with an air of disgust? Period product commercials that never mention menstruation (and what’s with the blue liquid?), sex education classes covering what periods are without advising how to manage them, the endless list of menstruation euphemisms, prominent evolutionary hypotheses dismissing periods as maladaptive, even proposed laws forbidding the discussion of periods in...
Apr 18, 2023•55 min•Transcript available on Metacast Even if you haven’t watched the TV show House MD, you’re probably familiar with the phrase “it’s never lupus”. But have you stopped to consider why it’s never lupus? Or why lupus is so often suspected in the first case? Well, dear listeners, this episode aims to get at the heart of those questions, which is easier said than done. Like many other autoimmune diseases, lupus erythematosus continues to baffle, but we know a lot more now than we used to. In this episode, we take you through that know...
Apr 04, 2023•2 hr 47 min•Transcript available on Metacast In our episode on the bends, you joined us as we explored how low we can go. Now we’re back with a similar invitation: come along to learn how high we can fly (and what happens to our bodies when we get up there). In this very special episode, we examine the short-term effects and potentially deadly consequences of life at great heights and ask how we came to understand the relationship between altitude, oxygen, and health. This journey begins earlier than you may have guessed, back to a time be...
Mar 21, 2023•2 hr 1 min•Transcript available on Metacast Listeners of this podcast are likely no strangers to the horrifying history of eugenics, a topic that has made an appearance in our episodes on epilepsy, Huntington’s disease, hemophilia, sickle cell anemia, and many others. We have touched on eugenic policies that prohibited marriage, encouraged and permitted forced sterilization, and restricted immigration in the U.S. in the early 20th century. But what we haven’t explored in great depth are the origins of eugenics as well as its disturbing pe...
Mar 14, 2023•55 min•Transcript available on Metacast For many of us, our encounters with listeria may not go beyond reading the occasional headline about an outbreak from contaminated hot dogs or listening to our doctor advise us to avoid certain foods while pregnant. But as we explore in this episode, the story of Listeria monocytogenes is more complex, scary, and unexpected than you may have imagined. Join us this episode as we trace the dual-natured and sometimes extremely deadly infections this pathogen can cause, examine how the industrial re...
Mar 07, 2023•2 hr 34 min•Transcript available on Metacast You may be wondering if there’s a typo in this week’s TPWKY book club selection - The Joy of Sweat? Are we supposed to find joy in this secretion? Shouldn’t it be The Inconvenience of Sweat? Some of you sauna-goers or hot yoga enthusiasts may already welcome sweat (at the right time and place, of course), but I’m guessing there are plenty of you out there that do everything you can to prevent perspiration and the odor that frequently accompanies it. In this bonus episode, Sarah Everts ( @saraeve...
Feb 28, 2023•1 hr 5 min•Transcript available on Metacast There is no shortage of ailments that vitamin D has been claimed to prevent or cure - various types of cancers, heart disease, COVID-19, diabetes, an assortment of autoimmune conditions, just to name a few. What is it about this micronutrient that leads people to behold it as a panacea? In this episode, we sift through what we know about the biology of vitamin D, along with what happens when you don’t have enough of it, in an attempt to discern what might be overhype and what might be underhype ...
Feb 21, 2023•2 hr 36 min•Transcript available on Metacast What do you get when you combine a love of reading with an interest in biology/public health/medical history and a background in podcasting? The TPWKY book club, of course! This season’s miniseries of bonus episodes features interviews with authors of popular science books, covering topics ranging from why sweat matters to the history of food safety, from the menstrual cycle to the persistence of race science and so much more. So dust off that library card, crack open that e-reader, fire up thos...
Feb 14, 2023•48 min•Transcript available on Metacast Only our second episode of the season and we’re already getting in over (and inside) our heads with one of the biggest topics we’ve taken on yet: epilepsy. In this episode, we navigate the constantly changing definitions of epilepsy, make our way through the many different types of seizures, and dig into the inner workings of the brain as we attempt to understand the pathophysiology of this disease. And that’s just the biology section! The history of epilepsy proves to be just as intense, as sho...
Feb 07, 2023•2 hr 39 min•Transcript available on Metacast We’re kicking off our sixth season in the same way we ended our fifth: with another headline-making respiratory virus. But as our listeners know, not all respiratory viruses are the same, and it’s often those differences among them that play the biggest role in their spread or the symptoms they cause. This episode, we’re exploring the virus that everyone has been talking about lately. No, not that one. Or that one. The other one. Yes, we’re talking about respiratory syncytial virus, or RSV. For ...
Jan 24, 2023•2 hr 30 min•Transcript available on Metacast Ep 110 Influenza, Take 2: Sitting Ducks; Fowl Play Over five years ago, on October 31, 2017, the very first episode of This Podcast Will Kill You premiered, an action-packed (and mildly disorganized) tour of the influenza virus and the 1918 flu pandemic. So much has happened since that episode’s release, both within the podcast and in the world of public health, not the least of which is a respiratory virus pandemic. Given this distance from the podcast’s beginning and the added perspective of e...
Nov 22, 2022•2 hr 32 min•Transcript available on Metacast Somehow it’s taken us until the penultimate episode to cover this season’s first mosquito-borne virus. But we assure you, this episode is well-worth the wait. Although Chikungunya virus is often lumped in with dengue or Zika, the unique characteristics that distinguish Chikungunya virus from these other arboviruses are just as important to note as the similarities among them. In this episode, we explore these differences and similarities in the biology of Chikungunya virus before reassessing wha...
Nov 08, 2022•1 hr 21 min•Transcript available on Metacast Although today we tend to think about diseases in terms of signs and symptoms, tests and treatments, that hasn’t always been the case. For much of history, diseases carried with them a deeper meaning beyond the pathophysiological processes leading to their development. A diagnosis was as much about the identity and personality of an individual as it was about the disease itself, and this was especially the case for the topic of today’s episode: gout. But before we get into the tangled history of...
Oct 25, 2022•1 hr 17 min•Transcript available on Metacast Over the years of the podcast, we have often struggled with questions of why: why pathogens act the way they do, why certain people get sick while others don’t, or why we know little about some diseases. This episode is no exception - sepsis certainly inspires many “whys”. But for perhaps the first time on the pod, we find ourselves grappling not only with “why?” but also with “what?”. What, indeed, is sepsis? Ask a dozen doctors and you may get a dozen different answers. Our first goal for this...
Oct 11, 2022•2 hr 40 min•Transcript available on Metacast Are you in the mood to chat chromosomes, specifically the X chromosome? If so, have we got the perfect episode for you! You may have come across the definition of Turner syndrome as a genetic condition resulting from the partial or complete loss of an X chromosome, but what does that actually mean? What is the X chromosome, what does it do, and why is it so important? We attempt to answer these questions with our exploration into the biology of Turner syndrome before setting our sights on the wh...
Sep 27, 2022•1 hr 28 min•Transcript available on Metacast We’ve covered measles, we’ve taken on rubella, and now we’re finishing up the classic MMR vaccine by exploring the other M: mumps. To some listeners, mumps may be a painful childhood memory while to others it’s just a letter in a vaccine they were too young to remember getting. But by the end of this episode, we promise that you’ll all be much more familiar with this strange little virus. How does the mumps virus make you sick and give you that classic swollen face look? What is so bad about the...
Sep 13, 2022•1 hr 17 min•Transcript available on Metacast Don your wetsuit, grab your oxygen tank, and securely fasten your mask, because this week we’re going on our deepest dive yet. In this episode, we’re plumbing the depths of decompression sickness, aka the bends, to get a better handle on how gases and pressure can be so very deadly. We start out with a bit of Gases 101, examining how decompression sickness occurs and why it affects your body in the ways it does. Next, we explore the not-so-distant history of this disease, a history that includes...
Aug 30, 2022•2 hr 44 min•Transcript available on Metacast The story of leptospirosis is chock full of variety. In terms of biology, any number of different Leptospira species and serovars can play a role in infection, and the resulting infection can run from asymptomatic to deadly. As for ecology, virtually any mammalian species can either act as an affected reservoir for the pathogens or fall victim to a deadly infection. The history of leptospirosis takes us across continents and through centuries, illustrating how changes in scientific thought and t...
Aug 16, 2022•1 hr 16 min•Transcript available on Metacast “The king of poisons,” “the poison of kings,” “inheritance powder.” As its various nicknames suggest, arsenic’s notoriety largely stems from its use as a murder weapon. But as we explore in this episode, the world of arsenic is much, much bigger than just as a plot device in an Agatha Christie novel, and it remains one of the most important environmental contaminants today. But how exactly does arsenic affect your body? When did people first start to use arsenic and for what purposes? Where does...
Aug 02, 2022•2 hr 34 min•Transcript available on Metacast For what was originally going to be our 100th regular season episode, we wanted to turn the vaguely threatening title of our podcast on its head by exploring a topic that’s not about something that can kill you but rather the hows and whys of staying alive, forever. That’s right, this week we’re taking on the immense and amorphous concept of immortality, viewed primarily through the lens of biology. Why don’t humans or any other organisms live forever, evolutionarily speaking? What can the long ...
Jul 19, 2022•1 hr 15 min•Transcript available on Metacast A little over two years into a pandemic, the last thing you probably want to see is headlines announcing yet another disease spreading across the globe. And yet, here we are. Beginning in May 2022, an increasing number of cases of monkeypox have been reported in many countries around the world, both in places where the monkeypox virus is known to occur as well as places where it had previously never been observed. And although the monkeypox virus itself is not new, some of the ways it is acting ...
Jul 12, 2022•2 hr 31 min•Transcript available on Metacast We’ve all been there: doubled over in pain as stomach cramps grip your guts; the panicked shuffle to the nearest bathroom; the waves of nausea and chills as you cry out loud, “oh no, what did I eat??”. At the very least, food poisoning is a humbling experience, but at the worst, it can be absolutely deadly. In this episode, we take a deep dive into one group of pathogens commonly responsible for outbreaks of food-borne illness, the infamous Salmonella . We start first with an exploration into ho...
Jun 21, 2022•2 hr 37 min•Transcript available on Metacast It’s been years since our first (and, until now, only) vitamin-centric episode on scurvy, and we’re thrilled to be dipping our toes back into these nutritious waters with this episode on folate. Have you ever wondered why folate is important or what the difference is between folate and folic acid? Or maybe you’re curious about this vitamin’s discovery and the impact that fortification programs have had around the world. Look no further - this episode has got all the folate facts you could desire...
Jun 07, 2022•1 hr 14 min•Transcript available on Metacast 
