TWiV 830: A culture of resistance

This Week in Virology

Nov 18, 2021•2 hr 8 min•Ep. 830

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Episode description

TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.

Hosts: Vincent Racaniello, Alan Dove, Rich Condi t, and Kathy Spindler

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Links for this episode

Spike protein inhibition of V(D)J recombination in vitro (Viruses)
Evolutionary predictability of SARS-CoV-2 (PLoS Path)
Letters read on TWiV 830
Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees

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