TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar
Episode description
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler
Guests: Moshe Arditi and Ivet Behar
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Links for this episode- MIS-C in US children (NEJM)
- Superantigen in spike and T cell skewing in MIS-C (PNAS)
- MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol)
- Antibody against bacterial superantigen blocks SARS-CoV-2 entry (Structure)
- Autoimmune signature of MIS-C in children (J Clin Invest)
- HLA1 associated T cell expansion in MIS-C (J Clin Invest)
- Passing of Bill Wold (one, two)
- Letters read on TWiV 815
- Timestamps by Jolene. Thanks!
Dickson – Mel Brooks
Kathy – Dickson’s art show at Fordham
Rich – Saildrone captures footage from inside Hurricane Sam
Vincent – A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman
Kathryn – Project Drawdown and the book
Charles – Arrowsmith by Sinclair Lewis
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]