TWiV 796: The vary hungry spike with Paul and Theodora

This Week in Virology

Aug 22, 2021•1 hr 54 min•Ep. 796

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Episode description

Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Paul Bieniasz and Theodora Hatiziiouannou

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Links for this episode

High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv)
Enhanced antibody one year after COVID-19 (Nature)
Letters read on TWiV 796
Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees

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