TWiV 1188: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information, the Marburg and Ebola outbreaks in Africa, the largest tuberculosis outbreak in the US ever, the politicization of polio vaccine campaigns in Pakistan, effect of high pathogenic influenza in animals and on the economy before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, trials and devices to relieve some neurological complications of long COVID and the ramifications of long COVID in children, healthcare workers and adults. 

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• No morbidity and mortality in the US this week? (NPR)
• More support for Marburg outbreak in Tanzania (Reliefweb)
• Tanzania confirming second Marburg case (CIDRAP)
• Norovirus mRNA vaccine …..hmmmm? (moderna)
• What is noronvirus? (modernatx)
• Largest tuberculosis outbreak ever in the US (Reuters)
• Ebola outbreak in DRC during US:WHO strain (STAT News)
• Uganda Ebola outbreak…..1 dead (Reuters)
• Polio outside endemic zone due to militants? (Washington Post)
• Mpox vaccination initiation in central Africa (CIDRAP)
• Preparing rapid response to emerging infectious disease in Africa (PANTHER Health)
• Mpox therapeutic study MOSA enrollment begins (Africa CDC)
• Halting of US foreign aid for health programs…..not in the US best interests? (NY Times)
• No PEPFAR (NY Times)
• PEPFAR (US Department of State)
• PEPFAR…..still not America first? Really? (CIDRAP)
• Resurgence of infections globally may affect US…..what is global health? (NY Times)
• Milk testing for H5N1….but I thought raw milk was the only healthy milk? (USDA)
• How do you like your $10.99 dozen of eggs? (NY Times)
• Farm outbreak of H5N1 (AP News)
• US- high pathogenicity avian influenza viruses (World Organization for Animal Health)
• H5N9 high pathogenic flu in duck farm California (CIDRAP)
• More egg issues (CIDRAP)
• Waste water scan for 11 pathogens (WastewaterSCan)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Weekly surveillance report: cliff notes (CDC FluView)
• RSV: Waste water scan for 11 pathogens (WastewaterSCan)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024 (LANCET Infectious Diseases)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Daniel Griffin’s evidence based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• The answers: Long COVID
• Long COVID Recovery Program with Zara Dureno, BA, MOT
• The current and future burden of long COVID in the United States (JID)
• Transcutaneous vagus nerve stimulation improves Long COVID symptoms in a female cohort (Frontiers in Neurology)
• Transcutaneous vagus nerve stimulation trials:
              https://www.mountsinai.org/clinical-trials/tvns-in-long-covid-19
              https://www.centerwatch.com/clinical-trials/listings/NCT06585254/tvns-in-long-covid-19
   Devices:
              https://pulsetto.tech/products/meet-pulsetto?pulsetto_offer_id=57&transaction_id=1024e5a0258b6647e262ba8fec5d62
              https://www.dolphinmps.com/product/dolphin-neurostim-professional-single-kit-vagal-stim-kit/
• Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls (Pediatric Research)
• Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection(PLoS Medicine)
• SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York (LANCET: Regional Health Americas)
• Impact of COVID-19 Pandemic on the incidence and prevalence of postural orthostatic tachycardia syndrome (EHJ-QCCO European Heart Journal-Quality of Care & Clinical Outcomes)
• Letters read on TWiV 1188
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene Ramsey. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]