TWiV 1146: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID.

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• Recommendations for seasonal influenza prevention and vaccines (MMWR)
• Gaza: poliovirus RNA in sewage water (Reuters)
• Success of the polio vaccination campaign in Gaza (Reuters)
• UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi)
• mpox vaccine tender (CIDRAP)
• What about vaccines? (Bavarian Nordic)
• Resolving food insecurity (UNICEF USA)
• Semaglutide and the SELECT trial(Journal of the American College of Cardiology)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Optimal duration of systemic corticosteroids treatment (OFID)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Does vaccination prevent long COVID (LANCET: Respiratory Medicine)
• Fibrin drives thromboinflammation & neuropathology in COVID-19(Nature)
• Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID)
• Letters read on TWiV 1146
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv