TWiV 1144: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.

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• Fauci recovering at home from West Nile Virus infection (STAT News)
• Gaza: poliovirus RNA in sewage water (GPEI)
• Bombs and polio…..cease fire, Oh my!  (Guardian)
• The variant type 2 poliovirus in Gaza  (United Nations: The Question of Palestine)
• 25 years polio free?  (Facebook)
• 2 doses of nOPV2= 1.2M vaccines=640,000 children (CNN)
• More polio……India, two-year-old child in Tikrikilla, Meghalaya (Business Standard)
• Sloth fever……Oropouche virus (USA Today)
• Oropouche virus disease import into US (MMWR)
• Gabon’s first case of mpox (CIDRAP)
• Declaration of mpox (Gabonese Republic Ministry of Health and Social Affairs)
• What about vaccines? (Bavarian Nordic)
• LC16 replicating smallpox vaccine (WHO)
• Historical smallpox vaccination against mpox clade II (Eurosurveillance)
• FDA approves Emergent Bio’s smallpox vaccine for mpox (Reuters)
• Mpox: epidemiology and vaccinology (Emerging Infectious Disease)
• Tecovirimat for MPOX? (STOMP)
• UGH! The WHO has a strategic preparedness and response plan to contain mpox outbreak (WHO)
• WHO preparedness plan prepares to lunch (CIDRAP)
• Working blindly against new mpox isolate (Reuters)
• CDC monkey pox response: TRANSMISSION ? (CDC Newsroom)
• The mpox (Africa CDC: Centers for Disease Control and Prevention)
• Evidence for mpox respiratory transmission(LANCET Microbe)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Four free COVID tests! (ASPR: Administration for Strategic Preparedness & Response)
• Great, more SARS-CoV-2 testing! (CIDRAP)
• EUA for updated Novavax COVID-19 vaccine (FDA)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• IDSA suggests new preventive COVID-19 agent (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Breakthrough from pemivibart/permgarda (bioRxiv)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Effectiveness of nirmatrelvir/ritonavir preventing hospitalization of high risk patients (Current Therapeutic Research)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• COVID-19, mental illness vaccinated and unvaccinated (JAMA Psychiatry)
• Post acute COVID- 19 outcomes amubarvimab/romlusevimab versus placebo (eClinical Medicine)
• Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID)
• Fibrin drives thromboinflammation & neuropathology in COVID-19 (Nature)
• Letters read on TWiV 1144
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]