In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection. Subscribe (free):...
Jun 18, 2022•47 min•Ep. 910
From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration. Hosts: Vincent Racaniello and Michael Schmidt Guests: Michele Banks and Jane Hartman Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Trilobite Glassworks (Jane Hartman) Artologica (Michele Banks) Science art with Michele Banks ( TWiV 352 ) Timestamps by Jolene . Thanks! Intro ...
Jun 16, 2022•47 min•Ep. 909
TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox update (CDC) SARS-CoV-2 infection of cats and dogs (Emerg Inf Dis) Mouse papillomavirus identification (Vet Patrol) Mouse model for papillom...
Jun 12, 2022•1 hr 45 min•Ep. 907
In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in h...
Jun 11, 2022•46 min•Ep. 908
TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox update (ProMedMail) Multi-country monkeypox outbreak (WHO) Monkeypox new global threat (Science) Monkeypox outbreak 9 US states (MMWR) Mimivirus in...
Jun 05, 2022•1 hr 46 min•Ep. 906
In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen tes...
Jun 04, 2022•44 min•Ep. 905
Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research. Hosts: Vincent Racaniello Guests: David Baltimore , John Coffin , and Harold Varmus Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Fifty Years of Reverse Transcriptase (Cold Spring Harbor Laboratory) 50th Anniversary ...
May 29, 2022•59 min•Ep. 904
In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and b...
May 28, 2022•48 min•Ep. 903
In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox multi-country outbreak risk assessment ( pdf , ECDC) Monkeypox update (ProMedMail) Monkeypox virus genome sequences (Nextstrain) Intro music is by Ronald Jenkees Send your questions for Dr. Griffin t...
May 26, 2022•26 min
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) Possible monkeypox in NYC (NY Times) Occupational monkeypox, Wisconsin (Emerg Inf...
May 22, 2022•2 hr 7 min•Ep. 902
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without vaccinatio...
May 21, 2022•1 hr•Ep. 901
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture Infected macrophages drives severe COVID-19 (Nature) Timestamps by Jolene . Thanks! Weekly Picks Brianne – ...
May 15, 2022•1 hr 35 min•Ep. 900
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effects of ...
May 14, 2022•56 min•Ep. 899
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases skin bacte...
May 08, 2022•1 hr 38 min•Ep. 898
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron o...
May 07, 2022•48 min•Ep. 897
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello , Dickson Despommier , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 89...
May 01, 2022•1 hr 42 min•Ep. 896
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Authorization for...
Apr 30, 2022•36 min•Ep. 895
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Severe hepatitis in children (WHO) TMPRSS2 inhibitor (Nature) Omicron less dependent on TMPRSS2 ( TWiV 879 ) Letters read on TWiV...
Apr 28, 2022•1 hr 40 min•Ep. 894
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guests: Kartik Chandran , Denise Haslwanter , and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode...
Apr 24, 2022•1 hr 28 min•Ep. 893
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune ...
Apr 23, 2022•54 min•Ep. 892
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Elke Muhlberger , Adam Hume , and Gabor Kemenesi Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious Lloviu vi...
Apr 21, 2022•1 hr 25 min•Ep. 891
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters...
Apr 17, 2022•1 hr 55 min•Ep. 890
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TW...
Apr 16, 2022•53 min•Ep. 889
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in ...
Apr 14, 2022•1 hr 30 min•Ep. 888
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a dominant H3N2...
Apr 10, 2022•1 hr 48 min•Ep. 887
In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cardiac complications after infection or vaccination (MM...
Apr 09, 2022•39 min•Ep. 886
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Sarbecovirus from Russian bat (bioRxiv) MVA vectored COVID vaccine (Sci Immunol) Letters read on TWiV 8...
Apr 07, 2022•1 hr 44 min•Ep. 885
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) SARS-CoV-2 ORF8 mimics IL-17 (mBio) Letters read on TWiV 884 Timestamps by Jolene . Thanks! Weekly Pick...
Apr 03, 2022•2 hr 2 min•Ep. 884
In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA authorizes second booster (FDA) Second booster and mortal...
Apr 02, 2022•45 min•Ep. 883
Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Understanding T cell responses during COVID-19 (Science Immunol) IL-1 and IL-1ra are keys to inflammation a...
Mar 31, 2022•1 hr 49 min•Ep. 882
