TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monoclonal antibody provides broad hantavirus protection (Sci Transl Med) Prometheus Pro...
Mar 27, 2022•1 hr 52 min•Ep. 881
In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia. S...
Mar 26, 2022•48 min•Ep. 880
TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2022 Emergence of remdesivir resistance (Nature Comm) How to stall...
Mar 24, 2022•1 hr 39 min•Ep. 879
TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CWD in meadow voles and raccoons (Emerg Inf Dis) Unusual infectious agents (...
Mar 20, 2022•2 hr 4 min•Ep. 878
In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episod...
Mar 19, 2022•28 min•Ep. 877
Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Michael Worobey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Early COVID-19 cases in Wuhan ( TWiV 833 ) Huanan market was epicenter of COVID-19 (Zenodo) Two spillover eve...
Mar 17, 2022•1 hr 37 min•Ep. 876
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait. Hosts: Vincent Racaniello , Dickson Despommier , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode WHO declaration of COVID-19 pandemic Virome of China game animals (Cell) ACE2 binding is ancestral and evolvable (Nature) Letters read on TWiV 875 Timestamps by Jolene . Thanks...
Mar 13, 2022•1 hr 33 min•Ep. 875
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Infection and changes in brain structure (Nature) Dementia among pneumonia survivors (Open Forum Inf Dis) Narrative...
Mar 12, 2022•41 min•Ep. 874
TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Click arrow to play Download TWiV 873 (128 MB .mp3, 107 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Porcine coronaviru...
Mar 06, 2022•1 hr 57 min•Ep. 873
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Link...
Mar 05, 2022•56 min•Ep. 872
TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registration (ASV) Microbiology & Immu...
Feb 27, 2022•1 hr 42 min•Ep. 871
In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for...
Feb 26, 2022•44 min•Ep. 870
TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Regi...
Feb 20, 2022•1 hr 48 min•Ep. 869
In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes. Subscribe (free): Apple Podcasts , Google Podcasts , RSS ...
Feb 19, 2022•46 min•Ep. 868
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Dorothy Horstmann (Wikipedia) Intranasal SARS-CoV-2 experimental vaccine (Cell) t-SNE (Wikipedia) Timestamps by Jolene...
Feb 17, 2022•1 hr 58 min•Ep. 867
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit Brianne Barker , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Cross-reactive...
Feb 13, 2022•1 hr 40 min•Ep. 866
In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children and COVID state data (AAP) Human challenge study (Res Sq) Effectiveness of mask use (MMWR) Omicron boost in macaques (bi...
Feb 12, 2022•48 min•Ep. 865
Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guests: John Dennehy , Marc Johnson , Davida Smyth , and Monica Trujillo Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 in NYC wastewater ( TWiV 737 ) Crypti...
Feb 10, 2022•1 hr 47 min•Ep. 864
TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Columbia University BSL-3 Mana...
Feb 06, 2022•1 hr 42 min•Ep. 863
In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC. Subscribe (free): Apple Podcasts , Google Podcasts ,...
Feb 05, 2022•38 min•Ep. 862
Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Nels Elde Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Columbia University BSL-3 Manager position Did Omicron come from mice? (J Genet Genomics) Persistent...
Feb 04, 2022•1 hr 54 min•Ep. 861
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Columbia University BSL-3 Manager position RNA modifications suppress innate ...
Jan 30, 2022•1 hr 49 min•Ep. 860
In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Omicron disease severity (MMWR) Neurologic manifes...
Jan 29, 2022•38 min•Ep. 859
John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Guest: John Mascola Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Accelerated COVID-19 vaccine development (Immunity) Letters read on TWiV 858 Timestamps by Jolene . Thanks! W...
Jan 28, 2022•1 hr 49 min•Ep. 858
Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Jon Yewdell on TWiV 208 , 467 , 597 , 620 Letters read on TWiV 857 Timestamps by Jolene . Thanks! Weekly Picks Jon – The Premonition by Mic...
Jan 23, 2022•1 hr 40 min•Ep. 857
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic. Click arrow to play Download TWiV 853 (58 MB .mp3, 48 min) Subscribe (free): iTunes , Google P...
Jan 22, 2022•51 min•Ep. 856
Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Alessandro Sette Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Travel Award Applications ( ASV ) 3:20 Impact of variants on T cells (Cell Rep Med) Timestamps by Jolene . Thanks! Letters read o...
Jan 21, 2022•1 hr 37 min•Ep. 855
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and B...
Jan 16, 2022•2 hr 6 min•Ep. 854
In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode...
Jan 15, 2022•54 min•Ep. 853
A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Travel Award Applications ( ASV ) CD28 deficiency and severe warts (Cell) Vincent interviews Harald zur Hausen (vi...
Jan 13, 2022•1 hr 44 min•Ep. 852
