Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit and Brianne Barker Guests: Chadi Saad-Roy and Caroline Wagner Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine nationalism and c...
Sep 19, 2021•1 hr 42 min•Ep. 807
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Hospitalization pre- and post-vaccines (Res Sq) Infection in children (medRxiv) Upda...
Sep 18, 2021•49 min•Ep. 806
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls Vaccine boosters not needed (Lancet) Delta variant replication and immune e...
Sep 16, 2021•1 hr 34 min•Ep. 805
Virus hunter Mya Breitbart joins TWiV to describe her laboratory's work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more. Hosts: Vincent Racaniello , Alan Dove , and Dickson Despommier Guest: Mya Breitbart Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Viruses of spinybacked orbweavers (J Gen Virol) Viruses of terrestrial arthropods (PeerJ) Pepper mild mottle virus in sewage (PLoS...
Sep 12, 2021•1 hr 51 min•Ep. 804
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Beco...
Sep 11, 2021•45 min•Ep. 803
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls SARS-CoV-2...
Sep 09, 2021•1 hr 47 min•Ep. 802
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade. Hosts: Vincent Racaniello , Alan Dove , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls COVID-19...
Sep 05, 2021•1 hr 57 min•Ep. 801
In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a ...
Sep 04, 2021•53 min•Ep. 800
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Neutralizing antibodies predict protection against symptom...
Sep 02, 2021•2 hr 8 min•Ep. 799
The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China. Hosts: Vincent Racaniello , Alan Dove , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Biden preliminary report on virus origins (NY Times) Window on SARS-CoV-2 origins c...
Aug 29, 2021•1 hr 57 min•Ep. 798
In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose. Hosts: Daniel G...
Aug 28, 2021•41 min•Ep. 797
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guests: Paul Bieniasz and Theodora Hatiziiouannou Subscribe (free): iTunes , Google Podcasts , RSS , e...
Aug 22, 2021•1 hr 54 min•Ep. 796
In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early conv...
Aug 21, 2021•37 min•Ep. 795
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Halls (ASV) Arboviral illness , US, 2019 (MMWR) Estimating SARS-CoV-2 infectiousness (Science) Timestamps by Jolene . Thanks...
Aug 15, 2021•1 hr 58 min•Ep. 794
In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a ...
Aug 14, 2021•41 min•Ep. 793
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Jeffrey Shaman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode A guide to R (Nature) Epidemiology of three SARS-CoV-2 VOC (medRxiv) Impact of delta variant i...
Aug 12, 2021•1 hr 40 min•Ep. 792
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 in wild deer (bioRxiv) Rapid T cell indu...
Aug 08, 2021•2 hr 4 min•Ep. 791
In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Beco...
Aug 07, 2021•49 min•Ep. 790
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NYC first to require vaccination proof (Reuters) Leaked internal CDC document (WaPo) Manuscripts on increased virulence ( on...
Aug 05, 2021•1 hr 49 min•Ep. 789
Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guest: Kiran Thakur Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 neuropathology (Brain) Infections in vaccinated people (MMWR) Infections in vaccin...
Aug 01, 2021•2 hr 2 min•Ep. 788
In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in ...
Jul 31, 2021•46 min•Ep. 787
TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Off-season RSV in Australia (medRxiv) Impaired innate immunity in severe COVID-19 (Cell) L...
Jul 29, 2021•1 hr 44 min•Ep. 786
In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Letters read on TWiV 785 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv...
Jul 28, 2021•59 min•Ep. 785
Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Alan Dove , and Brianne Barker Guests: Joseph Hyzer and Moriah Szpara Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron o...
Jul 25, 2021•1 hr 20 min•Ep. 784
In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries. Hosts: Daniel Griffin and ...
Jul 23, 2021•44 min•Ep. 783
On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Immune responses after heterologous COVID-19 vaccine boo...
Jul 22, 2021•1 hr 3 min•Ep. 782
The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 on dogs and c...
Jul 18, 2021•1 hr 47 min•Ep. 781
In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Pod...
Jul 17, 2021•41 min•Ep. 780
TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA ...
Jul 11, 2021•1 hr 40 min•Ep. 779
In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Efficacy of portable ai...
Jul 10, 2021•37 min•Ep. 778
