Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guests: Paul Bieniasz and Theodora Hatziioannou Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Evolutio...
Feb 07, 2021•1 hr 57 min•Ep. 717
In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a pat...
Feb 06, 2021•52 min•Ep. 716
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TMPRSS2 is why hydroxychloroquine failed (PLoS Path) Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) Letters read on TWiV 715 Timestamps by Jolene ....
Feb 04, 2021•1 hr 50 min•Ep. 715
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Guest: Jason McLellan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Prefusion spike structure (Scienc...
Jan 31, 2021•2 hr 7 min•Ep. 714
In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Novavax vaccine phase 3 results (Novavax) J&J vaccine phase 3 results (J&J) COVID-1...
Jan 30, 2021•35 min•Ep. 713
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guests: Gisa Gerold , Stefanie Becker , and César Muñoz-Fontela Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode German Society for Virology Ticks in Germany and TBEV (Sci Rep) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions ...
Jan 28, 2021•1 hr 38 min•Ep. 712
The TWiVers review Biden's national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Biden's COVID-19 strategy ( pdf ) CDC evaluation of BinaxNOW antigen test (MMWR) FDA instructions for BinaxNOW test ( pdf ) ...
Jan 24, 2021•2 hr•Ep. 711
In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron...
Jan 23, 2021•35 min•Ep. 710
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode President's science advisor to Cabinet (NY Times) Letter from Biden to Lander ( pdf ) Weekly flu (CDC)...
Jan 21, 2021•1 hr 30 min•Ep. 709
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times)...
Jan 17, 2021•2 hr 1 min•Ep. 708
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode J&J Ad26 vaccine phase 1/2 results (NEJM) SARS-CoV-2 encephalitis is a cytok...
Jan 16, 2021•40 min•Ep. 707
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse 2020 US traffic deaths (Car & Driver) National Vaccine Injury Compensation Program (HRSA) Jet injector (Wikipedia) Letters read on TWiV 706 Timestamps by Jolene . Than...
Jan 14, 2021•1 hr 36 min•Ep. 706
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Emily Travanty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode VOC detected in Colorado (WaPo) US has sequenced only 50,000 SARS-CoV-2 genomes (CDC) Huma...
Jan 10, 2021•1 hr 51 min•Ep. 705
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Argentine study on plasma therapy (NEJM) Ct values and clini...
Jan 09, 2021•32 min•Ep. 704
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position Follow authorize...
Jan 07, 2021•2 hr 5 min•Ep. 703
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse This little virus went ...
Jan 03, 2021•1 hr 37 min•Ep. 702
In Daniel Griffin's final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Attributes and predictors of long COVID-19 (medRxiv) Letters read on TWiV 701 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@mi...
Jan 02, 2021•39 min•Ep. 701
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position PHE update #2 ( pdf ) Sout...
Dec 31, 2020•2 hr 9 min•Ep. 700
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. Host: Vincent Racaniello Guests: Jonathan Auguste , Carol Blair , Desiree LaBeaud , Louis Lambrechts , and Mauricio Nogueira Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode RNAi in...
Dec 27, 2020•1 hr 27 min•Ep. 699
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Phased allocation of COVID-19 vaccines ( ACIP slides ) How CDC is making COVID-19 vaccine recommendations (CDC) Letters read ...
Dec 26, 2020•40 min•Ep. 698
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG...
Dec 24, 2020•2 hr 16 min•Ep. 697
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 lab...
Dec 20, 2020•2 hr 11 min•Ep. 696
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA EUA for Pfizer mRNA vaccine (FDA) Ellume at-home SARS-CoV-2 ant...
Dec 18, 2020•42 min•Ep. 695
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position TW...
Dec 17, 2020•1 hr 51 min•Ep. 694
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 laboratory assistant manager position FDA advisory committee votes in favor of EUA for Pfizer vaccine (NY Times) San...
Dec 13, 2020•1 hr 55 min•Ep. 693
Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mitigation strategies in early care and education settings (MMWR) WHO solidarity trial results (NEJM) Letters read on TWiV 692 Times...
Dec 11, 2020•38 min•Ep. 692
SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Laura Splan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this e...
Dec 10, 2020•2 hr 12 min•Ep. 691
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guest: Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NYC will create pandemic response institute (NY Bus J) Comparison of AC...
Dec 06, 2020•1 hr 59 min•Ep. 690
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vitamin D levels in COVID-19 patients (Nature) ACIP recommendations for distribution of COVID-19 vaccine (MMWR) Updated CDC guidance on when t...
Dec 05, 2020•37 min•Ep. 689
TWiV 688: We put COVID-19 papers through a sieve December 2, 2020 On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode UK grants EUA for Pfizer ...
Dec 03, 2020•1 hr 51 min•Ep. 688
